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Targeting Lysine Acetylation Readers and Writers [PDF]
Nature Reviews Drug DiscoveryLysine acetylation is a major post-translational modification in histones and other proteins that is catalysed by the ‘writer’ lysine acetyltransferases (KATs) and mediates interactions with bromodomains (BrDs) and other ‘reader’ proteins.
Philip A Cole, Ming-Ming Zhou
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Lysine acetylation regulates the interaction between proteins and membranes [PDF]
Nature Communications, 2021 Lysine acetylation regulates the function of soluble proteins in vivo, yet it remains largely unexplored whether lysine acetylation regulates the function of membrane proteins.
Alan K. Okada +14 more
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Characterizing lysine acetylation of glucokinase. [PDF]
Protein Sci, 2023 Glucokinase (GK) catalyzes the phosphorylation of glucose to form glucose‐6‐phosphate as the substrate of glycolysis for energy production. Acetylation of lysine residues in Escherichia coli GK has been identified at multiple sites by a series of ...
Fatema N, Li X, Gan Q, Fan C.
europepmc +4 more sources
Ancient Regulatory Role of Lysine Acetylation in Central Metabolism
mBio, 2017 Lysine acetylation is a common protein post-translational modification in bacteria and eukaryotes. Unlike phosphorylation, whose functional role in signaling has been established, it is unclear what regulatory mechanism acetylation plays and whether it ...
Ernesto S. Nakayasu +14 more
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The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation
Cellular & Molecular Biology Letters, 2022 Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signaling are still not fully elucidated.
Hongjuan You +6 more
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Regulation of Translation by Lysine Acetylation in Escherichia coli
mBio, 2022 Nε-lysine acetylation is a common posttranslational modification observed in diverse species of bacteria. Aside from a few central metabolic enzymes and transcription factors, little is known about how this posttranslational modification regulates ...
Sarah C. Feid +5 more
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Histone Deacetylases Control Lysine Acetylation of Ribosomal Proteins in Rice
Nucleic Acids Research, 2021 Lysine acetylation (Kac) is well known to occur in histones for chromatin function and epigenetic regulation. In addition to histones, Kac is also detected in a large number of proteins with diverse biological functions.
Dao-Xiu Zhou, Qiutao Xu, Yaping Yue
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Acetylome Analysis in Vibrio vulnificus MO6-24/O Reveals Extensive Lysine Acetylation in Carbon Metabolism and Protein Synthesis Pathways: A Pilot Study [PDF]
PathogensVibrio vulnificus (V. vulnificus) is a type of bacterium commonly found in estuarine environments. It can cause necrotizing wound infections and sepsis, both of which are associated with high mortality rates.
Yurong Song +8 more
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Cell Reports, 2017 Summary: Acetyl coenzyme A (AcCoA), a key intermediate in mitochondrial metabolism, N-acetylates lysine residues, disrupting and, in some cases, regulating protein function.
Andrew M James +2 more
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Lysine Acetylation of Cytoskeletal Proteins: Emergence of an Actin Code
Journal of Cell Biology, 2020 Higgs and colleagues review the emerging field of cytoskeletal lysine acetylation and discuss impacts of actin acetylation on its cytoplasmic and nuclear functions.
Henry N. Higgs, Laura E Pickrell
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