Results 31 to 40 of about 438,961 (309)

Molecular Characterization and Clinical Relevance of Lysine Acetylation Regulators in Urological Cancers

Frontiers in Oncology, 2021
BackgroundLysine acetylation and deacetylation are posttranslational modifications that are able to link extracellular signals to intracellular responses. However, knowledge regarding the status of lysine regulators in urological cancers is still unknown.
Jian Zhang, Chunning Zhang, Huali Jiang, Hualong Jiang, Yawei Yuan   +4 more
doaj   +1 more source

Lysine acetylation decreases enzyme activity and protein level of Escherichia coli lactate dehydrogenase

Engineering Microbiology, 2022
Lactate is an important bulk chemical with widespread applications and a major byproduct of other chemicals bioprocess in microbial fermentation. Lactate dehydrogenase A (LdhA) catalyzes the synthesis of lactate from pyruvate.
Min Liu, Meitong Huo, Likun Guo, Yingxin Fu, Mo Xian, Qingsheng Qi, Wei Liu, Guang Zhao   +7 more
doaj   +1 more source

Proteome-wide lysine acetylation profiling to investigate the involvement of histone deacetylase HDA5 in the salt stress response of Arabidopsis leaves.

The Plant Journal, 2023
Post-translational modifications (PTMs) of proteins play important roles in the acclimation of plants to environmental stress. Lysine acetylation is a dynamic and reversible PTM, which can be removed by histone deacetylases. Here we investigated the role
Priyadarshini Tilak, Florian Kotnik, G. Née, J. Seidel, Julia Sindlinger, Paulina Heinkow, Jürgen Eirich, D. Schwarzer, I. Finkemeier   +8 more
semanticscholar   +1 more source

Now Open: Evolving Insights to the Roles of Lysine Acetylation in Chromatin Organization and Function

Molecules and Cells, 2022
Protein acetylation is conserved across phylogeny and has been recognized as one of the most prominent post-translational modifications since its discovery nearly sixty years ago.
Ying-Jiun C. Chen, Evangelia Koutelou, Sharon Y. R. Dent   +2 more
semanticscholar   +1 more source

Lysine Acetylation/Deacetylation Modification of Immune-Related Molecules in Cancer Immunotherapy

Frontiers in Immunology, 2022
As major post-translational modifications (PTMs), acetylation and deacetylation are significant factors in signal transmission and cellular metabolism, and are modulated by a dynamic process via two pivotal categories of enzymes, histone ...
Peng Ding, Zhiqiang Ma, Dong Liu, Minghong Pan, Hui-Zi Li, Yingtong Feng, Yi-Meng Zhang, C. Shao, Menglong Jiang, Di Lu, Jing Han, Jinliang Wang, Xiaolong Yan   +12 more
semanticscholar   +1 more source

STALLION: a stacking-based ensemble learning framework for prokaryotic lysine acetylation site prediction

Briefings Bioinform., 2021
Protein post-translational modification (PTM) is an important regulatory mechanism that plays a key role in both normal and disease states. Acetylation on lysine residues is one of the most potent PTMs owing to its critical role in cellular metabolism ...
Shaherin Basith, Gwang Lee, Balachandran Manavalan   +2 more
semanticscholar   +1 more source

Bromodomain: an acetyl‐lysine binding domain [PDF]

FEBS Letters, 2002
Bromodomains, an extensive family of evolutionarily conserved protein modules originally found in proteins associated with chromatin and in nearly all nuclear histone acetyltransferases, have been recently discovered to function as acetyl‐lysine binding domains.
Zeng, Lei, Zhou, Ming-Ming
openaire   +2 more sources

Lysine acetylation of Escherichia coli lactate dehydrogenase regulates enzyme activity and lactate synthesis

Frontiers in Bioengineering and Biotechnology, 2022
As an evolutionarily conserved posttranslational modification, protein lysine acetylation plays important roles in many physiological and metabolic processes.
Min Liu, Meitong Huo, Changshui Liu, Likun Guo, Yamei Ding, Qingjun Ma, Qingsheng Qi, Mo Xian, Guang Zhao, Guang Zhao   +9 more
doaj   +1 more source

Regulation of epithelial-mesenchymal transition by protein lysine acetylation

Cell Communication and Signaling, 2022
The epithelial-mesenchymal transition (EMT) is a vital driver of tumor progression. It is a well-known and complex trans-differentiation process in which epithelial cells undergo morphogenetic changes with loss of apical-basal polarity, but acquire ...
Fan-Yun Kong, Lihong Ma, Xing Wang, Hong-Juan You, K. Zheng, Renxian Tang   +5 more
semanticscholar   +1 more source

Alterations of Lysine Acetylation Profile in Murine Skeletal Muscles Upon Exercise

Frontiers in Aging Neuroscience, 2022
ObjectiveRegular exercise is a powerful tool that enhances skeletal muscle mass and strength. Lysine acetylation is an important post-translational modification (PTM) involved in a broad array of cellular functions.
Dehuan Liang, Cheng Chen, Song Huang, Sujuan Liu, Li Fu, Yanmei Niu   +5 more
doaj   +1 more source