Results 41 to 50 of about 438,961 (309)

Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets [PDF]

International Journal of Molecular Sciences, 2022
Cyclophilin A (CyPA) is widely expressed by all prokaryotic and eukaryotic cells. Upon activation, CyPA can be released into the extracellular space to engage in a variety of functions, such as interaction with the CD147 receptor, that contribute to the pathogenesis of cardiovascular diseases.
Annabelle Rosa, Elke Butt, Christopher P. Hopper, Stefan Loroch, Markus Bender, Harald Schulze, Albert Sickmann, Sandra Vorlova, Peter Seizer, David Heinzmann, Alma Zernecke   +10 more
openaire   +3 more sources

Acetylation of Lactate Dehydrogenase Negatively Regulates the Acidogenicity of Streptococcus mutans

mBio, 2022
Lysine acetylation, a ubiquitous and dynamic regulatory posttranslational modification (PTM), affects hundreds of proteins across all domains of life.
Qizhao Ma, Yangyang Pan, Yang Chen, Shuxing Yu, Jun Huang, Yaqi Liu, Tao Gong, Qiong Zhang, Qun Sun, Jing Zou, Yuqing Li   +10 more
doaj   +1 more source

Advances in proteome-wide analysis of plant lysine acetylation

Plant Communications, 2021
Lysine acetylation (LysAc) is a conserved and important post-translational modification (PTM) that plays a key role in plant physiological and metabolic processes.
Lang Xia, Xiangge Kong, Hai-Feng Song, Qing-Quan Han, Shenmin Zhang   +4 more
semanticscholar   +1 more source

Contribution of Nε-lysine Acetylation towards Regulation of Bacterial Pathogenesis

mSystems, 2021
Nε-lysine acetylation is an important, dynamic regulatory posttranslational modification (PTM) that is common in bacteria. Protein acetylomes have been characterized for more than 30 different species, and it is known that acetylation plays important ...
J. Luu, Valerie J. Carabetta
semanticscholar   +1 more source

A Method to Determine Lysine Acetylation Stoichiometries [PDF]

International Journal of Proteomics, 2014
Lysine acetylation is a common protein posttranslational modification that regulates a variety of biological processes. A major bottleneck to fully understanding the functional aspects of lysine acetylation is the difficulty in measuring the proportion of lysine residues that are acetylated.
Nakayasu, Ernesto S., Wu, Si, Sydor, Michael A., Shukla, Anil K., Weitz, Karl K., Moore, Ronald J., Hixson, Kim K., Kim, Jong-Seo, Petyuk, Vladislav A., Monroe, Matthew E., Pasa-Tolic, Ljiljiana, Qian, Wei-Jun, Smith, Richard D., Adkins, Joshua N., Ansong, Charles   +14 more
openaire   +2 more sources

Acetylation site specificities of lysine deacetylase inhibitors in human cells [PDF]

, 2015
This work was supported by the Hallas Møller Investigator grant from the Novo Nordisk Foundation to C.C. S.A.W. and P.B. were supported by individual postdoctoral grants from the Danish Research Council (FSS: 10-085134, FSS: 12-12610). C.C.
Sebastian A Wagner, Jensen, Lars J., Jensen, Lars J, Chunaram Choudhary, Qi, Yun, Sonia Lain, Wagner, Sebastian A, Weinert, Brian T., James E Bradner, McCarthy, Anna R, Mann, Matthias, Yasuyuki Miyake, Westwood, Nicholas J, Schölz, Christian, Wagner, Sebastian A., Choudhary, Chunaram, Choudhary, Chuna Ram, Matthias, Patrick, Bradner, James E, Anna R McCarthy, Werner Streicher, Weinert, Brian Tate, Lain, Sonia, Bradner, James E., Matthias Mann, Nicholas J Westwood, Lars J Jensen, Jürgen Cox, Westwood, Nicholas James, Brian T Weinert, Cox, Jürgen, Christian Schölz, Streicher, Werner, McCarthy, Anna Rose, Lain, Sonya, Beli, Petra, Qi, Jun, Petra Beli, Jun Qi, Miyake, Yasuyuki, Patrick Matthias, Westwood, N., Miyake, Y., Scholz, C, Schölz C, Bradner JE, Lain S, Wagner, SA, Jensen, LJ, Mann, M., Choudhary, C., Streicher, W, Beli P, Westwood, NJ, Streicher W, Jensen, L., Qi, J, McCarthy AR, Qi, J., Qi J, Choudhary C, Lain, S., Weinert, B., Matthias, P., Mann M, Westwood NJ, Matthias P, McCarthy, A., Miyake, Y, Cox, J., Wagner SA, Schölz, C., Streicher, W., Weinert, BT, Beli, P, Weinert BT, Bradner, J., Cox J, Wagner, S., Beli, P., McCarthy, AR, Miyake Y, Jensen LJ, Westwood, Nicholas James; id_orcid   +83 more
core   +1 more source

The Cardiac Acetyl-Lysine Proteome

PLoS ONE, 2013
In the heart, lysine acetylation has been implicated in processes ranging from transcriptional control of pathological remodeling, to cardioprotection arising from caloric restriction. Given the emerging importance of this post-translational modification, we used a proteomic approach to investigate the broader role of lysine acetylation in the heart ...
D Brian Foster, Ting Liu, Jasma Rucker, Robert N O'Meally, Lauren R Devine, Robert N Cole, Brian O'Rourke   +6 more
openaire   +4 more sources

The Tale of Protein Lysine Acetylation in the Cytoplasm [PDF]

BioMed Research International, 2010
Reversible posttranslational modification of internal lysines in many cellular or viral proteins is now emerging as part of critical signalling processes controlling a variety of cellular functions beyond chromatin and transcription. This paper aims at demonstrating the role of lysine acetylation in the cytoplasm driving and coordinating key events ...
Sadoul, Karin, Wang, Jin, Diagouraga, Boubou, Khochbin, Saadi   +3 more
openaire   +2 more sources

H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation [PDF]

, 2011
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied.
Richard J. Festenstein, Bonneil, Eric, Guillemette Benoit, Festenstein Richard J., Armstrong Harry, Festenstein, Richard J., Harry Armstrong, Imhof Axel, Armstrong, Harry, Richard J Festenstein, Drogaris, Paul, Axel Imhof, Verreault Alain, Kyoko Hiragami-Hamada, Drogaris Paul, Verreault, Alain, Benoit Guillemette, Thibault Pierre, Pierre Thibault, Lin Hsiu-Hsu Sophia, Hiragami-Hamada, Kyoko, Alain Verreault, Imhof, Axel, Paul Drogaris, Hsiu-Hsu Sophia Lin, Bonneil Éric, Eric Bonneil, Festenstein, Richard J, Hiragami-Hamada Kyoko, Guillemette, Benoit, Lin, Hsiu-Hsu Sophia, Thibault, Pierre   +31 more
core   +1 more source

Studying the Lysine Acetylation of Malate Dehydrogenase [PDF]

Journal of Molecular Biology, 2017
Protein acetylation plays important roles in many biological processes. Malate dehydrogenase (MDH), a key enzyme in the tricarboxylic acid cycle, has been identified to be acetylated in bacteria by proteomic studies, but no further characterization has been reported. One challenge for studying protein acetylation is to get purely acetylated proteins at
Sumana, Venkat, Caroline, Gregory, Jourdan, Sturges, Qinglei, Gan, Chenguang, Fan   +4 more
openaire   +2 more sources