Results 61 to 70 of about 438,961 (309)

Imbalance of Lysine Acetylation Contributes to the Pathogenesis of Parkinson’s Disease

International Journal of Molecular Sciences, 2020
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. The neuropathological features of PD are selective and progressive loss of dopaminergic neurons in the substantia nigra pars compacta, deficiencies in striatal dopamine ...
Rui Wang, Hong-Yang Sun, Guanghui Wang, H. Ren   +3 more
semanticscholar   +1 more source

Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome

Frontiers in Cell and Developmental Biology, 2020
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders accompanied by obvious metabolic abnormalities. Lower-quality oocytes and embryos are often found in PCOS women during assisted reproductive technology treatment.
Zheying Min, X. Long, Hongcui Zhao, Xiu-Mei Zhen, Rong Li, Mo Li, Yong Fan, Yang Yu, Yue Zhao, J. Qiao   +9 more
semanticscholar   +1 more source

p53 Oligomerization is essential for its C-terminal lysine acetylation [PDF]

, 2009
Acetylation of multiple lysine residues in the p53 plays critical roles in p53’s protein stability and transcriptional activity. To better understand how p53 acetylation is regulated, we generated a number of p53 mutants and examined acetylation of each ...
Hengming Ke, Yanping Zhang, Itahana, Yoko, Zhang, Yanping, Ke, Hengming, Yoko Itahana   +5 more
core   +1 more source

serum lysine acetylation in Uyghur patients with T2DM

, 2021
Proteomic analysis of serum lysine acetylation in Uyghur patients with ...
liang yin (8502681)
core   +1 more source

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function [PDF]

, 2014
This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Wang, Jian, Pestell, RG0, Fuqua, Suzanne A W, Wang, Chenguang, Yeung, YG, Hopp, Torsten, Jaffray, E, Chang, Chawnshang, Fu, Maofu, Sakamaki, Toshiyuki, Janne, OA, Zhang, Xueping, Hay, Ronald Thomas, Palvimo, Jorma J   +13 more
core   +2 more sources

Large-scale identification of lysine acetylated proteins in vegetative hyphae of the rice blast fungus

Scientific Reports, 2017
Lysine acetylation is a major post-translational modification that plays important regulatory roles in diverse biological processes to perform various cellular functions in both eukaryotes and prokaryotes.
Xiaomei Sun, Zhigang Li, Hang Liu, Jun Yang, Wenxing Liang, You-Liang Peng, Jinguang Huang   +6 more
doaj   +1 more source

Lysine Acetylome Profiling Reveals Diverse Functions of Acetylation in Deinococcus radiodurans

Microbiology Spectrum, 2022
Lysine acetylation is a highly conserved posttranslational modification that plays essential roles in multiple biological functions in a variety of organisms. Deinococcus radiodurans (D.
Yongqian Zhang, Nuomin Li, Qiushi Wei, Rui Min, Feng Liu, Fuli Wang, Yulin Deng   +6 more
doaj   +1 more source

Functional consequences of lysine acetylation of phosphofructokinase isozymes. [PDF]

FEBS J
Phosphofructokinase (Pfk) catalyzes the phosphorylation of fructose 6‐phosphate and is a key regulatory point in the glycolysis pathway. Multiple lysine residues in both Pfk isozymes, PfkA and PfkB, have been identified to be acetylated in Escherichia coli by proteomic studies, but no studies
Li X, Fatema N, Gan Q, Fan C.
europepmc   +3 more sources

Vascular hyperacetylation is associated with vascular smooth muscle dysfunction in a rat model of non-obese type 2 diabetes

Molecular Medicine, 2022
Background Advanced type 2 diabetes mellitus (T2DM) accelerates vascular smooth muscle cell (VSMC) dysfunction which contributes to the development of vasculopathy, associated with the highest degree of morbidity of T2DM.
Maria Alicia Carrillo-Sepulveda, Nicole Maddie, Christina Mary Johnson, Cameron Burke, Osina Lutz, Bamwa Yakoub, Benjamin Kramer, Dhandevi Persand   +7 more
doaj   +1 more source

Lysine acetylation regulates the activity of nuclear Pif1 [PDF]

Journal of Biological Chemistry, 2020
In Saccharomyces cerevisiae, the Pif1 helicase functions in both nuclear and mitochondrial DNA replication and repair processes, preferentially unwinding RNA:DNA hybrids and resolving G-quadruplex structures. We sought to determine how the various activities of Pif1 are regulated in vivo Here, we report lysine acetylation of nuclear Pif1 and ...
Onyekachi E. Ononye, Christopher W. Sausen, Lata Balakrishnan, Matthew L. Bochman   +3 more
openaire   +2 more sources