Results 21 to 30 of about 438,961 (309)

Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation [PDF]

Cells, 2020
Diabetic nephropathy, a devastating consequence of diabetes mellitus, is characterized by the accumulation of extracellular matrix (ECM) that disrupts the kidney’s filtration apparatus. Elevated glucose levels increase the deposition of a fibronectin (FN)
Maria E. Vega, Birgit Kastberger, B. Wehrle-Haller, J. Schwarzbauer   +3 more
semanticscholar   +5 more sources

Dysregulation of lysine acetylation in the pathogenesis of digestive tract cancers and its clinical applications [PDF]

Frontiers in Cell and Developmental Biology
Recent advances in high-resolution mass spectrometry-based proteomics have improved our understanding of lysine acetylation in proteins, including histones and non-histone proteins.
Penghui Li, Yuan Xue
doaj   +2 more sources

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics

Chemical Reviews, 2018
Post-translational acetylation of lysine residues has emerged as a key regulatory mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique modification of histones, acetylation marks are now found on thousands of nonhistone ...
Melanie Ott, Eric M. Verdin, Ibraheem Ali   +2 more
exaly   +2 more sources

Lysine acetylation in obesity, diabetes and metabolic disease

Immunology & Cell Biology, 2011
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate acetylation and deacetylation of histone proteins and transcription factors.
Fairlie, David P., Lindsay Brown, Brown, Lindsay, Abishek Iyer, Iyer, Abishek, David P Fairlie   +5 more
core   +6 more sources

Bacteria employ lysine acetylation of transcriptional regulators to adapt gene expression to cellular metabolism [PDF]

Nature Communications
The Escherichia coli TetR-related transcriptional regulator RutR is involved in the coordination of pyrimidine and purine metabolism. Here we report that lysine acetylation modulates RutR function. Applying the genetic code expansion concept, we produced
Magdalena Kremer, Sabrina Schulze, Nadja Eisenbruch, Felix Nagel, Robert Vogt, Leona Berndt, Babett Dörre, Gottfried J. Palm, Jens Hoppen, Britta Girbardt, Dirk Albrecht, Susanne Sievers, Mihaela Delcea, Ulrich Baumann, Karin Schnetz, Michael Lammers   +15 more
doaj   +2 more sources

Regulation of Cellular Metabolism by Protein Lysine Acetylation [PDF]

Science, 2010
Metabolic Regulation Through Acetylation Covalent modification of lysine residues in various proteins in the nucleus is a recognized mechanism for control of transcription.
Shi-Min Zhao, Wei Xu, Wen-Qing Jiang, Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao, Li Zhou, Yaxue Zeng, Hong Li, Yi-Xue Li, Jiong Shi, Wen-Lin An, S. M. Hancock, F. He, L. Qin, J. Chin, Peng-Yuan Yang, Xian Chen, Qun-Ying Lei, Yue Xiong, K. Guan   +21 more
semanticscholar   +3 more sources

Acetylation of proximal cysteine-lysine pairs by alcohol metabolism

Redox Biology
Alcohol consumption induces hepatocyte damage through complex processes involving oxidative stress and disrupted metabolism. These factors alter proteomic and epigenetic marks, including alcohol-induced protein acetylation, which is a key post ...
Courtney D. McGinnis, Peter S. Harris, Brenton I.M. Graham, John O. Marentette, Cole R. Michel, Laura M. Saba, Richard Reisdorph, James R. Roede, Kristofer S. Fritz   +8 more
doaj   +2 more sources

Reprogramming of bacterial virulence by lysine acetylation. [PDF]

Nat Commun
Abstract Gram-negative bacteria use a plethora of virulence factors to infect eukaryotic cells. CE-clan protease-related virulence factors were reported to act as deubiquitinases/ubiquitin-like specific proteases. Some have an additional acetyl-transferase activity.
Schmöker O, Girbardt B, Schulze S, Palm GJ, Berndt L, Hoppen J, Kara N, Schöps X, Al-Abdulla R, Garz K, Junker H, Wolfgramm S, Steil L, Hentschker C, Schoknecht K, Mayer LM, Speth L, Lachmayer V, Dörr M, Kemnitz S, Müller S, Lackmann JW, Krüger M, Hofmann K, Bornscheuer UT, Völker U, Krüger E, Kozjak-Pavlovic V, Lammers M.   +28 more
europepmc   +3 more sources

Comparative study of lysine acetylation in Vesicomyidae clam Archivesica marissinica and the manila clam Ruditapes philippinarum: adaptation mechanisms in cold seep environments [PDF]

BMC Genomics
Background The deep-sea cold seep zone is characterized by high pressure, low temperature, darkness, and oligotrophy. Vesicomyidae clams are the dominant species within this environment, often forming symbiotic relationships with chemosynthetic microbes.
Xue Kong, Wei Wang, Sunan Chen, Manzong Song, Ying Zhi, Yuefeng Cai, Haibin Zhang, Xin Shen   +7 more
doaj   +2 more sources

Research progress on lysine acetylation (Review). [PDF]

Int J Mol Med
Lysine acetylation is recognized as a critical and reversible post‑translational modification that is essential for numerous cellular functions and biological processes. The dynamic interplay between lysine acetylation and deacetylation to regulates a wide spectrum of processes, including histone modification, gene expression, cell cycle progression ...
Zhang M, Zhang Y, Yin H, Yan J, Dong Y, Zhao X, Cui T, Lv B, Gao X.   +8 more
europepmc   +3 more sources