Results 191 to 200 of about 206,586 (259)

Inhibition of Acetylation Activity of p300/CBP Ameliorates Hepatic Steatosis Through Downregulation of ACSL4. [PDF]

Liver Int
Cai LY, Guan YP, Hu JH, Sun CY, Ding CH, Zhang X, Zeng X, Xie WF.   +7 more
europepmc   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Targeting post-translational modifications to overcome glioblastoma therapy resistance: emerging strategies and natural compounds. [PDF]

Front Oncol
Piermartiri T, da Matta ACA, Pinto JVK, Tasca CI, Nedel CB.   +4 more
europepmc   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Ketogenic diet attenuates Müller cell activation and retinal neuroinflammation in autoimmune glaucoma through acetylation‑mediated FOXO signalling. [PDF]

Int J Mol Med
Tan S, Wang X, Zheng Y, Mou Z, Zeng L, Yuan J, Fan X, Wei M, Huo Y, Ouyang R, Pu Y, Lei J, Gao X, Wang D, Peng Y, Li H.   +15 more
europepmc   +1 more source

Postnatal ketone deficiency impairs adult oocyte quality via enhancing histone acetylation in malnourished mice. [PDF]

J Biol Chem
Zhang XG, Li MZ, Sha H, Tao SY, Qiao Y, Yang QW, Wang LR, Zhang XQ, Chong DY, Hu ZB, Lin Y, Ling XF, Li CJ.   +12 more
europepmc   +1 more source

Integrated transcriptome analysis and machine learning to construct a homeostatic model of acetylation for bladder cancer and validate the key gene <i>CES1</i>. [PDF]

Transl Androl Urol
Cao J, Yang J, Shang W, Tan H, Zhou Q, Jia B, Guo J.   +6 more
europepmc   +1 more source

The role of lysine acylation in metabolic dysregulation and inflammatory responses within the hepatic immune microenvironment of MASLD. [PDF]

Front Immunol
Peng J, Yan A, Chen G, Gao X, Yu Q, Tian W, Cai K.   +6 more
europepmc   +1 more source