Results 191 to 200 of about 230,380 (304)

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms. [PDF]

Proc Natl Acad Sci U S A
Costantino L, Ye T, Boardman K, Xiang S, Luo J, Mu Y, Ma W, Koshland D.   +7 more
europepmc   +1 more source

Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction

Advanced NanoBiomed Research, EarlyView.
In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen, Michael B. Nguyen, Elliot Widd, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Houston Harding, Chloe Hurteau, Anika Yogi, Colin Luo, Rebecca L. Braden, Pedro Cabrales, Karen L. Christman   +14 more
wiley   +1 more source

An intricate functional relationship between NuA4 and Sfp1 regulates ribosome biogenesis in response to nutrient availability. [PDF]

J Biol Chem
Xu K, Bianco S, Beauparlant CJ, Côté V, Herrmann L, Droit A, Downey M, Nourani A, Côté J.   +8 more
europepmc   +1 more source

Mind the size: LARGE3-OsHDT1 complex keeps rice grain size in line. [PDF]

Plant Cell
Pereyra-Bistraín LI.
europepmc   +1 more source

HDAC8 impairs tight junctions in allergic rhinitis through Smad7 deacetylation. [PDF]

Front Immunol
Chang HH, Cao ZN, Dang PH, Wei M, Li Y, Zhang HP, Wang J.   +6 more
europepmc   +1 more source

[Expression of Concern] Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects. [PDF]

Int J Oncol
Carlisi D, Vassallo B, Lauricella M, Emanuele S, D'anneo A, Di Leonardo E, Di Fazio P, Vento R, Tesoriere G.   +8 more
europepmc   +1 more source

Acetylation.

Experimental Biology and Medicine, 1927
B. Harrow, F. W. Power, C. P. Sherwin
openaire   +1 more source

HATs off to OsHAG704 and OsBPM2: novel regulators of OsRpp30 in rice blast resistance. [PDF]

Plant Physiol
Freed CP.
europepmc   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source