Results 231 to 240 of about 204,757 (287)

Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of nucleosome arrays. [PDF]

Nat Commun
Gao J, Li H, Tan S, Zhou R, Lee TH.
europepmc   +1 more source

Efficient Preparation of Homogenous Antibody Conjugates via Glycosite‐Specific Transglycosylation Enabled by Readily Available Glycosyl Donors

Angewandte Chemie, EarlyView.
A streamlined platform for glycosite‐specific antibody conjugation is enabled by LacNAc‐derived cyclic acetal donors, which can be prepared in only two steps and used directly in single‐enzyme Endo S2‐mediated transglycosylation. The platform supports the broad construction of homogeneous gsADCs and gsDACs, with donor 7 producing glycoengineered ...
Deqin Cai, Yuan Zhao, Gaoyuan Lu, Chunrong Li, Yichong Lao, Ramesh Mudududdla, Jiahao Zhang, Peijing Jia, Penghsuan Huang, Wenxin Wu, Thao‐Vy T. Nguyen, Xuhui Huang, Lingjun Li, Weiping Tang   +13 more
wiley   +1 more source

Cistromic insight into the association of retinoid X receptor with MyoD and CTCF in proliferating myoblasts. [PDF]

Sci Rep
Clément JT, Li Q.
europepmc   +1 more source

Mechanochemical Synthesis of X‐Vinylbenziodoxol(on)es and One‐Pot Conversion to Complex Alkenes**

Angewandte Chemie, EarlyView.
The synthesis of a wide range of complex 1,2‐di(heteroatom)‐substituted (Z)‐alkenes is achieved through a mechanochemical one‐pot reaction of ethynylbenziodoxol(on)es (EBX/EBO) with a variety of heteroatom nucleophiles. The mechanochemical activation enables synthesis of a range of novel vinylbenziodoxol(on)es (VBX/VBO) whose synthesis is inefficient ...
Sayad Doobary, Judith Braunreuther, Andrew K. Inge, Berit Olofsson   +3 more
wiley   +1 more source

Role of histone post-translational modifications in atherosclerosis and the therapeutic potential of targeting epigenetic modifiers. [PDF]

Front Cell Dev Biol
Wu L, Li W, Ye W.
europepmc   +1 more source

Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos

Angewandte Chemie, EarlyView.
We report a new chiral phosphine ligand, sRuPhos, which permits the highly enantioselective Suzuki–Miyaura coupling of ortho‐aniline and ortho‐phenol building blocks. This results in 2‐amino‐2′‐hydroxybiphenyls with very high enantiomeric excesses, products that will have application in pharmaceutical synthesis and ligand design for catalysis ...
Hamzah Sharif, Luke A. McCall, Matthew G. Sanders, Robert J. Phipps   +3 more
wiley   +1 more source

Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

Angewandte Chemie, EarlyView.
Macrocycles are effective molecular glues to stabilize the 14‐3‐3/ChREBP interaction. Linker length modulation uncovered an inverse correlation between the macrocycle binding affinity to 14‐3‐3 and its cooperativity in 14‐3‐3/ChREBP stabilization.
Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert J. Markvoort, Galen P. Miley, Luc Brunsveld   +7 more
wiley   +1 more source

Urinary acetylated protein as a biomarker of lupus nephritis: a prospective cohort study. [PDF]

Arthritis Res Ther
Lee YJ, Lee EJ, Kim K, Kim M, Yu JY, Kim M, Ahn SM, Hong S, Lee CK, Yoo B, Kim YG.   +10 more
europepmc   +1 more source

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues

Angewandte Chemie, EarlyView.
Marine polyhydroxylated macrolides’ drug discovery potential is limited by structural complexity and scarce material supply, hindering structure assignment, synthesis, and biological studies. Here, we present an integrated workflow that combines chemogenomic profiling, ultra‐high‐resolution NMR‐guided structural revision and stereochemical assignment ...
Malcolm R. P. George, Lobna A. Elsadek, Max Deering, Larissa Costa de Almeida, Jasper L. Tyler, Adam Noble, Valerie J. Paul, Hendrik Luesch, Craig P. Butts, Varinder K. Aggarwal   +9 more
wiley   +1 more source

Sirt6 prevents the age-related decline of H₂S through the control of one-carbon metabolism. [PDF]

Proc Natl Acad Sci U S A
Touitou N, Nahum L, Feldman-Trabelsi S, Avivi MY, Aon MA, Naiman S, Rathaus M, Gertler AA, Roichman A, Berkman Dvir L, Bernier M, Banskota N, Beck L, Nagar R, Schwartz Z, Price NL, Harel M, Lerrer B, Ishii I, Senderowitz H, Moaddel R, Geiger T, de Cabo R, Cohen HY.   +23 more
europepmc   +1 more source