Results 41 to 50 of about 387,548 (381)
Histone acetylation and the role of histone deacetylases in normal cyclic endometrium
Reproductive Biology and Endocrinology, 2020 Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation. The human
Palak Gujral +3 more
semanticscholar +1 more source
Acetylation, Deacetylation and Acyltransfer [PDF]
Environmental Health Perspectives, 1983 N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. Decreasing the levels of metabolites,
Irene B. Glowinski, Charles M. King
openaire +3 more sources
Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]
, 2011 Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Arteaga-Salas, Jose M. +6 more
core +5 more sources
Lysine acetylation regulates the interaction between proteins and membranes
Nature Communications, 2021 Lysine acetylation regulates the function of soluble proteins in vivo, yet it remains largely unexplored whether lysine acetylation regulates the function of membrane proteins.
Alan K. Okada +14 more
doaj +1 more source
Effects of α-tubulin acetylation on microtubule structure and stability
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Microtubules are polymers of αβ-tubulin that play important roles in the cell. Regulation of their dynamics is critical for function and includes the posttranslational modification of tubulin.
L. Eshun-Wilson +9 more
semanticscholar +1 more source
A moonlighting metabolic protein influences repair at DNA double-stranded breaks. [PDF]
, 2015 Catalytically active proteins with divergent dual functions are often described as 'moonlighting'. In this work we characterize a new, chromatin-based function of Lys20, a moonlighting protein that is well known for its role in metabolism.
Aris, John P +2 more
core +1 more source
Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Chemical Reviews, 2018 Post-translational acetylation of lysine residues has emerged as a key regulatory mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique modification of histones, acetylation marks are now found on thousands of nonhistone ...
Ibraheem Ali +3 more
semanticscholar +1 more source
Studying Acetylation of Aconitase Isozymes by Genetic Code Expansion
Frontiers in Chemistry, 2022 Aconitase catalyzes the second reaction of the tricarboxylic acid cycle, the reversible conversion of citrate and isocitrate. Escherichia coli has two isoforms of aconitase, AcnA and AcnB. Acetylomic studies have identified acetylation at multiple lysine
Jessica Araujo +5 more
doaj +1 more source
Spotlight on protein N-terminal acetylation
Experimental and Molecular Medicine, 2018 N-terminal acetylation (Nt-acetylation) is a widespread protein modification among eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino group, the charge, hydrophobicity, and size of the N-terminus is altered in an ...
Rasmus Ree, Sylvia Varland, T. Arnesen
semanticscholar +1 more source
Cell, 2001 Recent studies suggest that acetylation of the p53 tumor suppressor protein is not important for its DNA binding activity, as was previously thought. We discuss here a number of theories as to how this modification may serve to regulate the protein's functions.
James L. Manley, Carol Prives
openaire +3 more sources