Results 71 to 80 of about 387,548 (381)

The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken [PDF]

, 2005
The replacement histone H2A.Z is variously reported as being linked to gene expression and preventing the spread of heterochromatin in yeast, or concentrated at heterochromatin in mammals.
Bonifer, C., Bruce, K., Crane-Robinson, C., Greaves, I., Lefevre, P., Mantouvalou, E., Myers, F.A., Thorne, A.W., Tremethick, D.J.   +8 more
core   +5 more sources

ALCOHOL METABOLISM CONTRIBUTES TO BRAIN HISTONE ACETYLATION

Nature, 2019
Emerging evidence suggests that epigenetic regulation is dependent on metabolic state, and implicates specific metabolic factors in neural functions that drive behaviour1.
Philipp Mews, Philipp Mews, G. Egervari, Raffaella Nativio, Simone Sidoli, Simone Sidoli, G. Donahue, Sonia I Lombroso, D. Alexander, S. L. Riesche, E. Heller, E. Nestler, Benjamin A. Garcia, S. Berger   +13 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Smad1 Promotes Tumorigenicity and Chemoresistance of Glioblastoma by Sequestering p300 From p53

Advanced Science
Acetylation is critically required for p53 activation, though it remains poorly understood how p53 acetylation is regulated in glioblastoma (GBM). This study reveals that p53 acetylation is a favorable prognostic marker for GBM, regardless of p53 status,
Lingli Gong, Daxing Xu, Kaixiang Ni, Jie Li, Wei Mao, Bo Zhang, Zhening Pu, Xiangming Fang, Ying Yin, Li Ji, Jingjing Wang, Yaling Hu, Jiao Meng, Rui Zhang, Jiantong Jiao, Jian Zou   +15 more
doaj   +1 more source

Lysine acetylation decreases enzyme activity and protein level of Escherichia coli lactate dehydrogenase

Engineering Microbiology, 2022
Lactate is an important bulk chemical with widespread applications and a major byproduct of other chemicals bioprocess in microbial fermentation. Lactate dehydrogenase A (LdhA) catalyzes the synthesis of lactate from pyruvate.
Min Liu, Meitong Huo, Likun Guo, Yingxin Fu, Mo Xian, Qingsheng Qi, Wei Liu, Guang Zhao   +7 more
doaj  

Acetylated Thioredoxin Reductase 1 Resists Oxidative Inactivation

Frontiers in Chemistry, 2021
Thioredoxin Reductase 1 (TrxR1) is an enzyme that protects human cells against reactive oxygen species generated during oxidative stress or in response to chemotherapies. Acetylation of TrxR1 is associated with oxidative stress, but the function of TrxR1
David. E. Wright, Nikolaus Panaseiko, Patrick O’Donoghue, Patrick O’Donoghue   +3 more
doaj   +1 more source

Turning off the switch in medulloblastoma. The inhibitory acetylation of an oncogene [PDF]

, 2010
[No abstract ...
CANETTIERI, Gianluca, CONI, SONIA, DI MARCOTULLIO, LUCIA, GRECO, Azzura, GULINO, Alberto   +4 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Dynamic Protein Acetylation in Plant-Pathogen Interactions

Frontiers in Plant Science, 2016
Pathogen infection triggers complex molecular perturbations within host cells that results in either resistance or susceptibility. Protein acetylation is an emerging biochemical modification that appears to play central roles during host-pathogen ...
Gaoyuan eSong, Justin William Walley
doaj   +1 more source

A Stoichiometric Solvent-Free Protocol for Acetylation Reactions

Frontiers in Chemistry, 2022
Considering the remarkable relevance of acetylated derivatives of phenols, alcohols, and aryl and alkyl thiols in different areas of biology, as well as in synthetic organic chemistry, a sustainable solvent-free approach to perform acetylation reactions ...
Francesca Valentini, Pierluca Galloni, Pierluca Galloni, Diana Brancadoro, Valeria Conte, Federica Sabuzi, Federica Sabuzi   +6 more
doaj   +1 more source