Results 11 to 20 of about 180,246 (294)

A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

open access: yeseLife, 2021
Basal forebrain cholinergic neurons (BFCNs) project throughout the cortex to regulate arousal, stimulus salience, plasticity, and learning. Although often treated as a monolithic structure, the basal forebrain features distinct connectivity along its ...
Blaise Robert   +6 more
doaj   +1 more source

Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions

open access: yesFrontiers in Behavioral Neuroscience, 2022
Introduction: Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer’s disease, Tourette syndrome, epilepsy among others.
R. Oliver Goral   +11 more
doaj   +1 more source

Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the Neurotransmitter Acetylcholine

open access: yesmBio, 2022
Acetylcholine is a central biological signal molecule present in all kingdoms of life. In humans, acetylcholine is the primary neurotransmitter of the peripheral nervous system; it mediates signal transmission at neuromuscular junctions.
Miguel A. Matilla   +7 more
doaj   +1 more source

Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundEndothelial dysfunction is an early stage of atherosclerosis. Single‐nucleotide polymorphisms (SNPs) have been associated with vascular dysfunction, cardiac events, and coronary artery remodeling.
Satoshi Yoshino   +9 more
doaj   +1 more source

Acetylcholine [PDF]

open access: yesBritish Journal of Pharmacology, 2006
This article traces the development of knowledge about the physiology and pharmacology of acetylcholine and its receptors between 1930 and 2005, with emphasis on contributions by members of the British Pharmacological Society, and by other British pharmacologists and physiologists.British Journal of Pharmacology(2006)147, S120–S126.
openaire   +2 more sources

Anti-MuSK antibody positive myasthenia gravis with childhood onset [PDF]

open access: yesRomanian Journal of Neurology, 2016
Myasthenic syndromes are acquired diseases which unite the impairment of neuromuscular transmission with associated muscle weakness, occasional positive anti-acetylcholine or MuSK antibodies and characteristic electrodiagnostic features.
Diana Epure   +2 more
doaj   +1 more source

Is There a Canonical Cortical Circuit for the Cholinergic System? Anatomical Differences Across Common Model Systems

open access: yesFrontiers in Neural Circuits, 2018
Acetylcholine (ACh) is believed to act as a neuromodulator in cortical circuits that support cognition, specifically in processes including learning, memory consolidation, vigilance, arousal and attention. The cholinergic modulation of cortical processes
Jennifer J. Coppola, Anita A. Disney
doaj   +1 more source

Novel Carbon/PEDOT/PSS-Based Screen-Printed Biosensors for Acetylcholine Neurotransmitter and Acetylcholinesterase Detection in Human Serum

open access: yesMolecules, 2019
New reliable and robust potentiometric ion-selective electrodes were fabricated using poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) as the solid contact between the sensing membrane and electrical substrate for an acetylcholine (ACh)
Nashwa H. Ashmawy   +5 more
doaj   +1 more source

GABAB Receptor Signaling in the Dorsal Motor Nucleus of the Vagus Stimulates Gastric Motility via a Cholinergic Pathway

open access: yesFrontiers in Neuroscience, 2019
Central nervous system regulation of the gastric tone and motility is primarily mediated via preganglionic neurons of the dorsal motor nucleus of the vagus (DMV).
Maureen T. Cruz   +5 more
doaj   +1 more source

Comparative analysis of three different protocols for cholinergic neuron differentiation in vitro using mesenchymal stem cells from human dental pulp

open access: yesAnimal Cells and Systems, 2019
A decrease in the activity of choline acetyltransferase, the enzyme responsible for acetylcholine synthesis in the cholinergic neurons cause neurological disorders involving a decline in cognitive abilities, such as Alzheimer’s disease.
Young-Hoon Kang   +9 more
doaj   +1 more source

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