Results 41 to 50 of about 227,192 (263)

Cholinergic Pathway SNPs and Postural Control in 477 Older Adults

Frontiers in Aging Neuroscience, 2018
Objective: To determine whether single nucleotide polymorphisms (SNPs) of the cholinergic system and quantitative parameters of postural control are associated in healthy older adults.
Carina Arnold, Carina Arnold, Claudia Schulte, Claudia Schulte, Mariana Moscovich, Ulrike Sünkel, Ulrike Sünkel, Laura Zaunbrecher, Laura Zaunbrecher, Florian Metzger, Florian Metzger, Thomas Gasser, Thomas Gasser, Gerhard W. Eschweiler, Gerhard W. Eschweiler, Ann-Kathrin Hauser, Ann-Kathrin Hauser, Daniela Berg, Daniela Berg, Daniela Berg, Walter Maetzler, Walter Maetzler, Walter Maetzler   +22 more
doaj   +1 more source

Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane [PDF]

, 2012
Agrin is the major factor mediating the neuronal regulation of postsynaptic structures at the vertebrate neuromuscular junction, but the details of how it orchestrates this unique three-dimensional structure remain unknown.
Jeffrey van Haren, Galjart N, Sladecek, S. (Stefan), Haren, Jeffrey van, van Haren, J., Hans Rudolf Brenner, Schmidt, Nadine, Treves, Susan, van Haren J, Pielage, J. (Jan), Jan Pielage, Sreya Basu, Brenner H.R., TREVES, Susan Nella, Gatti, Sabrina, Pielage J, Schmidt N, van Haren, Jeffrey; id_orcid, Pielage, Jan, Galjart, Niels; id_orcid, Basu S, Gatti, A. (Arianna), Brenner, H.R. (Hans Rudolf), Niels Galjart, Sladecek, S., Gatti S, Basu, Sreya, Susan Treves, Schmidt, N. (Nico), Sabrina Gatti, Haren, J.A.J. (Jeffrey) van, Treves, S., Galjart, N., Stefan Sladecek, Pielage, J., Brenner, H. R., Basu, S. (Saonli), Galjart, N.J. (Niels), Gatti, S., Nadine Schmidt, Sladecek S, Galjart, Niels, Schmidt, N., Basu, S., Sladecek, Stefan, Brenner, Hans Rudolf, Treves S, Brenner HR   +47 more
core   +1 more source

The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test

Biomedical Papers, 2015
Aims: The number of approved drugs for the clinical treatment of Alzheimer disease remains limited. For this reason, there is extensive search for novel therapies.
Jan Misik, Jan Korabecny, Eugenie Nepovimova, Pavla Cabelova, Jiri Kassa   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cholinergic Modulation of Cortical Microcircuits Is Layer-Specific: Evidence from Rodent, Monkey and Human Brain

Frontiers in Neural Circuits, 2017
Acetylcholine (ACh) signaling shapes neuronal circuit development and underlies specific aspects of cognitive functions and behaviors, including attention, learning, memory and motivation.
Joshua Obermayer, Matthijs B. Verhoog, Antonio Luchicchi, Huibert D. Mansvelder   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Involvement of Acetylcholine Receptors in Cholinergic Pathway-Mediated Protection Against Autoimmune Diabetes

Frontiers in Immunology, 2019
Type I diabetes (T1D) is a T cell-driven autoimmune disease that results in the killing of pancreatic β-cells and, consequently, loss of insulin production.
Maria J. Fernández-Cabezudo, Junu A. George, Ghada Bashir, Yassir A. Mohamed, Alreem Al-Mansori, Mohammed M. Qureshi, Dietrich E. Lorke, Georg Petroianu, Basel K. al-Ramadi, Basel K. al-Ramadi   +9 more
doaj   +1 more source

Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary

Frontiers in Endocrinology, 2021
The functioning of the ovary is influenced by the autonomic system (sympathetic and cholinergic intraovarian system) which contributes to the regulation of steroid secretion, follicular development, and ovulation.
Agustin Benitez, Raul Riquelme, Miguel del Campo, Camila Araya, Hernan E. Lara   +4 more
doaj   +1 more source

Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]

, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Wunder, C., Peigneur, S., Silke Kauferstein, Melaun, Christian, Annette Nicke, Nicke, Annette, Dietrich Mebs, Christian Melaun, Peigneur, Steve, Kauferstein, S., Kauferstein, Silke, Wunder, Cora, Kendel, Y., Mebs, D., Kurz, A., Steve Peigneur, Tytgat, Jan, Melaun, C., Kendel, Yvonne, Kurz, Alexander, Mebs, Dietrich, Yvonne Kendel, Jan Tytgat, Cora Wunder, Alexander Kurz, Nicke, A., Tytgat, J.   +26 more
core   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source