Results 31 to 40 of about 227,192 (263)

Impaired muscarinic modulation of the rat prelimbic cortex in neuropathic pain is sexually dimorphic and associated with cold allodynia

Frontiers in Cellular Neuroscience, 2023
Cholinergic modulation of the brain cortex is critical for cognitive processes, and altered cholinergic modulation of the prefrontal cortex is emerging as an important mechanism of neuropathic pain.
Taylor Jefferson, Haram R. Kim, Marco Martina   +2 more
doaj   +1 more source

Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions

Frontiers in Behavioral Neuroscience, 2022
Introduction: Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer’s disease, Tourette syndrome, epilepsy among others.
R. Oliver Goral, R. Oliver Goral, Kathryn M. Harper, Briana J. Bernstein, Briana J. Bernstein, Sydney A. Fry, Sydney A. Fry, Patricia W. Lamb, Sheryl S. Moy, Jesse D. Cushman, Jesse D. Cushman, Jerrel L. Yakel   +11 more
doaj   +1 more source

Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids [PDF]

, 2011
The nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission in the brain and peripheral nervous system.
Shanata, Jai Anand Pattur
core   +1 more source

Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site. [PDF]

, 1995
Agrin is a basal lamina protein that induces aggregation of acetylcholine receptors (AChRs) and other molecules at the developing neuromuscular junction.
Ruegg, M. A., A J Denzer, Denzer, A J, M A Ruegg, Gesemann, M., M Gesemann, Gesemann, M, Ruegg, M A, Denzer, A. J., Gesemann M, Denzer AJ, Ruegg MA   +11 more
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AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity [PDF]

, 2007
Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack ...
Sixma, Titia K., Alewood, Paul F., Buettner, Regina, van Elk, R, Smit, A.B., Sixma, T., Dutertre, S., Nicke, A, van Elk, R., Smit, A., Nicke, Annette, Alewood, P. F., Sixma, T.K., Kendel, Y., Smit, AB, Lewis, R. J., Hopping, G., Kendel, Y, Büttner, Regina, Elk, René van, Ulens, C, Ulens, Chris, Buttner, R, Kendel, Yvonne, Sixma, TK, Fish, Alexander, Lewis, R.J., Schroeder, Christina, Lewis, Richard,, Smit, August,, Alewood, P.F., Lewis, Richard J., Fish, A, Sixma, Titia,, Schroeder, C., Alewood, Paul,, Fish, A., Alewood, P., Dutertre, Sébastien, Smit, August B., Ulens, C., Hopping, Gene, Nicke, A., Lewis, R., Ulens, Chris (author), Schroeder, Christina (author), Dutertre, Sébastien (author), Lewis, Richard J. (author), Lewis, Richard, J, Büttner, Regina (author), van Elk, René (author), Alewood, Paul, F, Fish, Alexander (author), Nicke, Annette (author), Sixma, Titia, K, Kendel, Yvonne (author), Hopping, Gene (author), Alewood, Paul F. (author), Sixma, Titia K. (author), Smit, August, B, Smit, August B. (author), Büttner, R., van Elk, Rene   +62 more
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Acetylcholine receptors (muscarinic) in GtoPdb v.2021.2 [PDF]

, 2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine.
Kilbinger, Heinz J., Schwarz, Roy D., Christopoulos, Arthur, Buckley, Noel J., Langmead, Chris, Hammer, Rudolf, Thal, David, Tobin, Andrew B., Bradley, Sophie, Brown, David A., Ehlert, Frederick, Challiss, R.A. John, Mutschler, Ernst, Valant, Celine, Eglen, Richard M., Wess, Jurgen, Felder, Christian C., Birdsall, Nigel J. M., Lambrecht, Günter, Nathanson, Neil M., Mitchelson, Fred, Rudolf Hammer, Günter Lambrecht, Arthur Christopoulos, Richard M. Eglen, Neil M. Nathanson, Noel J. Buckley, R.A. John Challiss, Nigel J. M. Birdsall, Andrew B. Tobin, Roy D. Schwarz, Sophie Bradley, Heinz J. Kilbinger, Fred Mitchelson, Ernst Mutschler, Jurgen Wess, Christian C. Felder, David Thal, David A. Brown, Chris Langmead, Celine Valant, Frederick Ehlert   +41 more
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Mini Review: the non-neuronal cardiac cholinergic system in type-2 diabetes mellitus

Frontiers in Cardiovascular Medicine
Diabetic heart disease remains the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Both insulin resistance and metabolic derangement, hallmark features of T2DM, develop early and progressively impair cardiovascular function ...
Eng Leng Saw, Martin Fronius, Rajesh Katare, Yoshihiko Kakinuma   +3 more
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The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain

Frontiers in Cellular Neuroscience, 2018
Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of ...
Anna Ronowska, Andrzej Szutowicz, Hanna Bielarczyk, Sylwia Gul-Hinc, Joanna Klimaszewska-Łata, Aleksandra Dyś, Marlena Zyśk, Agnieszka Jankowska-Kulawy   +7 more
doaj   +1 more source

Endothelial Dysfunction and Passive Changes in the Aorta and Coronary Arteries of Diabetic db/db Mice

Frontiers in Physiology, 2020
Endothelial cell dysfunction and vessel stiffening are associated with a worsened prognosis in diabetic patients with cardiovascular diseases. The present study hypothesized that sex impacts endothelial dysfunction and structural changes in arteries from
Lilliana Beck, Junjing Su, Simon Comerma-Steffensen, Simon Comerma-Steffensen, Estéfano Pinilla, Rune Carlsson, Raquel Hernanz, Raquel Hernanz, Majid Sheykhzade, Carl Christian Danielsen, Ulf Simonsen   +10 more
doaj   +1 more source

Paroxysmal Atrial Fibrillation during Spasm Provocation Test with Acetylcholine: Clinical Characteristics of Patients and Effect on Coronary Microvascular Function Measurements

Reviews in Cardiovascular Medicine
Background: Atrial fibrillation (AF) is a complication that occurs following a spasm provocation test (SPT) with acetylcholine (ACh). However, the characteristics of patients with AF remain unclear.
Hiroki Teragawa, Chikage Oshita, Yu Hashimoto, Shuichi Nomura   +3 more
doaj   +1 more source