Results 31 to 40 of about 436,718 (339)

Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]

, 2008
We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel, Arendt, Atack, Bain, Bear, Blanquet, Bliss, Blitzer, Blitzer, Bogan, Casey, Charpantier, Cho, Dajas-Bailador, Davies, Davis, Decker, Dhavan, Dominguez del Toro, English, Faghih, Fujii, Giovannini, Gray, Hope, Huang, Huang, Hunter, Hurst, Ji, Jones, Kawakami, Kelly, Kihara, Klein, Krause, Le Novere, Levin, Li, Liston, Lu, Man, Mann, Marrero, Matsuyama, Matthies, Meriane, Opazo, O’Dell, Peavy, Picciotto, Polesskaya, Polesskaya, Radcliffe, Roberson, Rush, Salazar, Sanna, Sanna, Santos, Seguela, Sharifzadeh, Sharifzadeh, Sharma, Shaw, Shaw, Sweatt, Takada-Takatori, Tominaga-Yoshino, Wada, Wang, Wang, Welsby, Welsby, Whitehouse, Woo, Wu, Yang, Ying, Yu, Zhang, Zwart   +81 more
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The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking. [PDF]

, 2020
Nicotinic acetylcholine receptors (AChRs) are pentameric channels that mediate fast transmission at the neuromuscular junction (NMJ) and defects in receptor expression underlie neuromuscular disorders such as myasthenia gravis and congenital myasthenic ...
Borges, Lucia Soares, Ferns, Michael, Rudell, Jolene Chang, Yarov-Yarovoy, Vladimir   +3 more
core  

Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region [PDF]

, 1992
Tris+/Na+ permeability ratios were measured from shifts in the biionic reversal potentials of the macroscopic ACh-induced currents for 3 wild- type (WT), 1 hybrid, 2 subunit-deficient, and 25 mutant nicotinic receptors expressed in Xenopus oocytes.
Cohen, Bruce N., Czyzyk, Linda, Davidson, Norman, Labarca, Cesar, Lester, Henry A.   +4 more
core   +2 more sources

Mini Review: the non-neuronal cardiac cholinergic system in type-2 diabetes mellitus

Frontiers in Cardiovascular Medicine
Diabetic heart disease remains the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Both insulin resistance and metabolic derangement, hallmark features of T2DM, develop early and progressively impair cardiovascular function ...
Eng Leng Saw, Martin Fronius, Rajesh Katare, Yoshihiko Kakinuma   +3 more
doaj   +1 more source

The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain

Frontiers in Cellular Neuroscience, 2018
Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of ...
Anna Ronowska, Andrzej Szutowicz, Hanna Bielarczyk, Sylwia Gul-Hinc, Joanna Klimaszewska-Łata, Aleksandra Dyś, Marlena Zyśk, Agnieszka Jankowska-Kulawy   +7 more
doaj   +1 more source

Endothelial Dysfunction and Passive Changes in the Aorta and Coronary Arteries of Diabetic db/db Mice

Frontiers in Physiology, 2020
Endothelial cell dysfunction and vessel stiffening are associated with a worsened prognosis in diabetic patients with cardiovascular diseases. The present study hypothesized that sex impacts endothelial dysfunction and structural changes in arteries from
Lilliana Beck, Junjing Su, Simon Comerma-Steffensen, Simon Comerma-Steffensen, Estéfano Pinilla, Rune Carlsson, Raquel Hernanz, Raquel Hernanz, Majid Sheykhzade, Carl Christian Danielsen, Ulf Simonsen   +10 more
doaj   +1 more source

Characterisation of nicotine receptors on human peripheral blood mononuclear cells (PBMC) [PDF]

, 2009
“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s00011-008-8171-xAim and objective: The aim of the work was to characterise the nAChRs on human PBMC.
Parsons, M., Whelan, C.J., Wongsriraksa, A.   +2 more
core   +1 more source

ATP as a presynaptic modulator [PDF]

, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
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Paroxysmal Atrial Fibrillation during Spasm Provocation Test with Acetylcholine: Clinical Characteristics of Patients and Effect on Coronary Microvascular Function Measurements

Reviews in Cardiovascular Medicine
Background: Atrial fibrillation (AF) is a complication that occurs following a spasm provocation test (SPT) with acetylcholine (ACh). However, the characteristics of patients with AF remain unclear.
Hiroki Teragawa, Chikage Oshita, Yu Hashimoto, Shuichi Nomura   +3 more
doaj   +1 more source

Cholinergic Pathway SNPs and Postural Control in 477 Older Adults

Frontiers in Aging Neuroscience, 2018
Objective: To determine whether single nucleotide polymorphisms (SNPs) of the cholinergic system and quantitative parameters of postural control are associated in healthy older adults.
Carina Arnold, Carina Arnold, Claudia Schulte, Claudia Schulte, Mariana Moscovich, Ulrike Sünkel, Ulrike Sünkel, Laura Zaunbrecher, Laura Zaunbrecher, Florian Metzger, Florian Metzger, Thomas Gasser, Thomas Gasser, Gerhard W. Eschweiler, Gerhard W. Eschweiler, Ann-Kathrin Hauser, Ann-Kathrin Hauser, Daniela Berg, Daniela Berg, Daniela Berg, Walter Maetzler, Walter Maetzler, Walter Maetzler   +22 more
doaj   +1 more source