Results 171 to 180 of about 116,282 (198)

Muscarinic Acetylcholine Receptors

Current Pharmaceutical Design, 2006
Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru Ishii, Yoshihisa Kurachi
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The biochemistry of an acetylcholine receptor

Journal of Supramolecular Structure, 1974
AbstractThe acetylcholine receptor from Torpedo californica electroplax has been studied at three levels of molecular organization: receptor‐rich membrane fragments, solubilized and purified receptor, and reconstituted receptor in phospholipid vesicles.
Michael A. Raftery, R. Vandlen, J. Duguid, D. Michaelson, Y. Chao, K. Reed, J. Bode, T. Moody, J. Deutsch   +8 more
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Muscarinic acetylcholine receptor

Progress in Neurobiology, 1978
ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
Edith Heilbronn, Tamas Bartfai
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Acetylcholine receptors

Quarterly Reviews of Biophysics, 1974
The idea that certain drugs and neurotransmitters produce their effects by combining with specific receptors was first clearly expressed by Langley (1905) on the basis of the selective and localized effect of nicotine on striated muscle fibres. In 1914, Langley published a paper in which the antagonism between ‘curari’ and nicotine ...
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Isolation of Acetylcholine Receptors

Annual Review of Pharmacology, 1972
When ACh acts in an excitatory way, it increases the conductance of a post-synaptic membrane for Na+ and K+, leading to membrane depolariza­ tion. We shall use the term acetylcholine receptor (AChR) for those ma­ cromolecules involved in this transduction that bear the recognition site( s) for ACh and other cholinergic ligands.
R D O'Brien, A T Eldefrawi, M E Eldefrawi   +2 more
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Phosphorylation of the Acetylcholine Receptor

1979
There is increasing evidence that disorders of recep tor function account for several major clinical diseases. In the nervous system, two of the most striking examples are myasthenia gravis and tardive dyskinesia. Each of these conditions is associated with a change in the number and/or sensitivity of a neurotransmitter receptor.
Ivan Diamond, Adrienne S. Gordon
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Nicotinic Acetylcholine Receptors

2003
Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
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Immunology of the Acetylcholine Receptor

Immunological Communications, 1976
Myasthenia gravis is a spontaneously occurring autoimmune disease in which antibodies and lymphocytes are specifically reactive with nicotinic ACh receptors of skeletal muscle. Antibodies reactive with junctional receptors of human muscle are found in 90% of patients with myasthenia gravis and not at all in other diseases.
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Acetylcholine Receptor Structure

2003
Over the past decade, studies of the atomic structure and the structural mechanism of nicotinic acetylcholine receptor (AChR) gating have reached an advanced stage. AChRs are members and prototypes of the superfamily of Cys-loop pentameric ligand-gated ion channels.
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Acetylcholine receptors and myasthenia

Muscle & Nerve, 2000
Much progress has been made in the 26 years since initial studies of the first purified acetylcholine receptors (AChRs) led to the discovery that an antibody-mediated autoimmune response to AChRs causes the muscular weakness and fatigability characteristic of myasthenia gravis (MG) and its animal model, experimental autoimmune myasthenia gravis (EAMG).
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