Results 181 to 190 of about 217,964 (360)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Surprises From the Basal Ganglia: Stop and Go Have New Meaning

Movement Disorders, EarlyView.
Abstract This perspective highlights new work suggesting the need for revision of the canonical direct–indirect model of the basal ganglia's influence on movement, with fresh evidence that there is a formerly unappreciated pair of direct and indirect pathways that parallel the standard model's canonical direct and indirect pathways, and promising ...
Ann M. Graybiel
wiley   +1 more source

Distribution of acetylcholine receptors at frog neuromuscular junctions with a discussion of some physiological implications.

, 1978
Julia Matthews-Bellinger, Miriam M. Salpeter   +1 more
openalex   +2 more sources

The role of a reactive disulphide bond in the function of the acetylcholine receptor at the frog neuromuscular junction [PDF]

, 1973
D. Ben-Haim, E M Landau, Israel Silman
openalex   +1 more source

ACETYLCHOLINE RECEPTOR

British Journal of Anaesthesia, 1982
openaire   +2 more sources

Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Visual hallucinations (VHs) are a common feature of Parkinson's disease (PD) believed to arise from disruptions to the functional architecture supporting sensory integration and attentional control. Across synucleinopathies, increased pathological burden in the amygdala and deficits in cholinergic modulation have been linked to VHs.
Anna Ignatavicius, Lachlan Churchill, Jack Anderson, Ajay Konuri, Claire O'Callaghan, Simon J.G. Lewis, Elie Matar   +6 more
wiley   +1 more source

Muscarinic acetylcholine receptors in developing chick heart

, 1977
Jonas Galper, William L. Klein, William A. Catterall   +2 more
openalex   +1 more source

SIZES OF END PLATE COMPARTMENTS, DENSITIES OF ACETYLCHOLINE RECEPTOR AND OTHER QUANTITATIVE ASPECTS OF NEUROMUSCULAR TRANSMISSION [PDF]

, 1973
Miriam M. Salpeter, Mohyee E. Eldefrawi
openalex   +1 more source

Levodopa Disrupts Activity Patterns and Encoding of Movement in Striatal Cholinergic Interneurons of Behaving Mice

Movement Disorders, EarlyView.
Abstract Objectives Levodopa treatment, the gold standard therapy for Parkinson's disease, can lead to levodopa‐induced dyskinesias (LIDs). Recent studies in acute brain slices have implicated the neural dynamics of striatal cholinergic interneurons (CINs) in the pathophysiology of LID, reporting that their discharge becomes more bursty in dyskinetic ...
Yara Atamna, Lior Tiroshi, Nadine Wattad, Naomi Gilin, Shelly Gilad, Noa Berkowitz, Joshua A. Goldberg   +6 more
wiley   +1 more source

Structural insights into the progressive recovery of α7 nicotinic acetylcholine receptor from nicotine-induced desensitization. [PDF]

Sci Adv
Liu S, Chen H, Zhu X, Ye F, Zhao Y, Qin J, Zheng Y, Wang X, Zhang L, Chen H, Li X, Mu W, Fu Y, Luo C, Hou H, Bai C, Liu L, Tian C.   +17 more
europepmc   +1 more source