Results 181 to 190 of about 2,529,430 (407)

Reaction of tetraethylammonium with the open and closed conformations of the acetylcholine receptor ionic channel complex. [PDF]

, 1979
Michael Adler, A. C. B. de Oliveira, E X Albuquerque, N. A. Mansour, Amira T. Eldefrawi   +4 more
openalex   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Perampanel as a second‐line therapy to midazolam reduces soman‐induced status epilepticus and neurodegeneration in rats

Epilepsia Open, EarlyView.
Abstract Objective A benzodiazepine (diazepam or midazolam) is one of the current standards of care therapies to effectively terminate organophosphorus nerve agent‐induced status epilepticus when administered shortly after onset. Preclinical studies showed that benzodiazepines were less effective in stopping status epilepticus when treatment was ...
Hailey G. Steier, Caroline R. Schultz, Jerome Niquet, Donna A. Nguyen, Michael F. Stone, Abiel K. Biney, Marcio de Araujo Furtado, Claude G. Wasterlain, Lucille A. Lumley   +8 more
wiley   +1 more source

Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. II. The Mode of Action of Parathion on an Acetylcholine Receptor.

, 1963
Masayasu Kimura, Toshiji Igarashi, Sadao Iwashita   +2 more
openalex   +2 more sources

M1 muscarinic acetylcholine receptor in Alzheimer’s disease

Neuroscience Bulletin, 2014
Shangtong Jiang, Yanfang Li, Cuilin Zhang, Yingjun Zhao, G. Bu, Huaxi Xu, Yun-wu Zhang   +6 more
semanticscholar   +1 more source

Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines

Environmental Toxicology and Chemistry, EarlyView.
Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz, Krittika Mittal, Na'im Temlock, Jessica Head, Niladri Basu   +4 more
wiley   +1 more source

Phytochemistry, pharmacological insights, and food science applications of natural bioactive compounds from Ocimum species with a focus on essential oils

Food Frontiers, EarlyView.
The article examines the phytochemistry, pharmacology, and food science applications of essential oils and extracts from Ocimum species (basil). It covers diverse extraction methods like hydrodistillation and microwave‐assisted extraction while discussing pharmacological benefits.
Oberdan Oliveira Ferreira, Ravendra Kumar, Luiz Renan Ramos da Silva, Suraj N. Mali, Srushti Tambe, Ulisses Alves Rosa, Leonardo Souza Costa, Lohren Glendha Nunes Lobato, Anderson de Santana Botelho, Himani Karakoti, Sonu Kumar Mahawer, Marcilene Paiva da Silva, Mozaniel Santana de Oliveira, Eloisa Helena de Andrade Aguiar   +13 more
wiley   +1 more source

Studies on 4-Aminobutyric Acid- and Acetylcholine-Receptors by the Employing of Graphic Method. III. : The Relationship between Acetylcholine- and 4-Amino-butyric Acid-Actions and the Role of Sodium- and Calcium-Ions

, 1966
Hiro‐o Kamiya, Tomitaro KITA
openalex   +2 more sources

Membranes Rich in Acetylcholine Receptor: Characterization and Reconstitution to Excitable Membranes from Exogenous Lipids [PDF]

, 1978
W Schiebler, Ferdinand Hucho
openalex   +1 more source

Exploring the Multifunctional Agents of Flavonoid‐Rich Beet Leaf Extracts: Insights From Experimental and Computational Studies

Food Safety and Health, EarlyView.
ABSTRACT This study evaluated the multifunctional ability of Beta vulgaris leaves in dual therapy for Alzheimer's disease (AD) and type 2 diabetes (T2D). Flavonoid‐rich extracts of B. vulgaris leaves (FREBVL) were tested for their antidiabetic properties. The inhibition of α‐amylase and α‐glucosidase was assessed. Anti‐cholinesterase activities against
Gideon Ampoma Gyebi, Damilare Emmanuel Rotimi, Moyosoreoluwa Oduba, Ifeoma Nnonyelu, Matthew Iyobhebhe, Musiliyu Ayofe Salawu, Adebola Busola Ojo, Odunayo Anthonia Taiwo, Adesoji Alani Olanrewaju, Abel Kolawole Oyebamiji, Mubarak Alruwaili, Naif H. Ali, Saud A. Alnaaim, Bshra A. Alsfouk, Gaber El‐Saber Batiha, Oluwafemi Adeleke Ojo   +15 more
wiley   +1 more source