Results 11 to 20 of about 116,282 (198)
Frontiers in Neural Circuits, 2022 The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention, vigilance, learning and memory. ACh is released during different behavioural states and affects the brain microcircuit by regulating neuronal and synaptic properties ...
Guanxiao Qi +3 more
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Pharmaceuticals, 2023 Neuropathic pain affects about 7–8% of the population, and its management still poses challenges with unmet needs. Over the past decades, researchers have explored the cholinergic system (muscarinic and nicotinic acetylcholine receptors: mAChR and nAChR)
Edouard Montigné, David Balayssac
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Simultaneous Presence of Acetylcholine Receptor and Muscle Specific Tyrosine Kinase Antibodies in Myasthenia Gravis [PDF]
International Journal of Basic Science in Medicine, 2019 Myasthenia gravis (MG) is known as an autoimmune disorder which affects transmission in neuromuscular junction. The serologic tests used for diagnosis include acetylcholine receptor and muscle specific receptor tyrosine kinase antibodies.
Maryam Poursadeghfard, Sara Azhdari
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A potential cost of evolving epibatidine resistance in poison frogs
BMC Biology, 2023 Background Some dendrobatid poison frogs sequester the toxin epibatidine as a defense against predators. We previously identified an amino acid substitution (S108C) at a highly conserved site in a nicotinic acetylcholine receptor β2 subunit of ...
Julia M. York +4 more
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PLoS ONE, 2023 Organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. Here, we use the organophosphate paraoxon-ethyl to treat C.
Patricia G Izquierdo +6 more
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A novel labeling approach identifies three stability levels of acetylcholine receptors in the mouse neuromuscular junction in vivo. [PDF]
PLoS ONE, 2011 BACKGROUND: The turnover of acetylcholine receptors at the neuromuscular junction is regulated in an activity-dependent manner. Upon denervation and under various other pathological conditions, receptor half-life is decreased.
Siegfried Strack +8 more
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Sequence of age-associated changes to the mouse neuromuscular junction and the protective effects of voluntary exercise. [PDF]
PLoS ONE, 2013 Loss of connections between motor neurons and skeletal muscle fibers contribute to motor impairment in old age, but the sequence of age-associated changes that precede loss of the neuromuscular synapse remains uncertain.
Anson Cheng +5 more
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Loss of Acetylcholine Signaling Reduces Cell Clearance Deficiencies in Caenorhabditis elegans. [PDF]
PLoS ONE, 2016 The ability to eliminate undesired cells by apoptosis is a key mechanism to maintain organismal health and homeostasis. Failure to clear apoptotic cells efficiently can cause autoimmune diseases in mammals.
Sérgio M Pinto +3 more
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Frontiers in Veterinary Science, 2023 A 9-year-old male neutered Cockapoo was presented with an acute and progressive history of exercise induced weakness involving all limbs, and bilateral decreased ability to blink.
Thomas Mignan +6 more
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The role of muscarinic receptors in the beneficial effects of adenosine against myocardial reperfusion injury in rats. [PDF]
PLoS ONE, 2011 Adenosine, a catabolite of ATP, displays a wide variety of effects in the heart including regulation of cardiac response to myocardial ischemia and reperfusion injury.
Lei Sun +8 more
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