Results 41 to 50 of about 128,683 (214)

Functional validation of novel levamisole resistance marker S168T in Haemonchus contortus

International Journal for Parasitology: Drugs and Drug Resistance
Recently, a S168T variant in the acetylcholine receptor subunit ACR-8 was associated with levamisole resistance in the parasitic helminth Haemonchus contortus.
Alistair Antonopoulos, Claude L. Charvet, Kirsty Maitland, Stephen R. Doyle, Cédric Neveu, Roz Laing   +5 more
doaj   +1 more source

The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis

JCI Insight, 2021
A dynamically regulated microenvironment, which is mediated by crosstalk between adipocytes and neighboring cells, is critical for adipose tissue homeostasis and function.
Wen Meng, Ting Xiao, Xiuci Liang, Jie Wen, Xinyi Peng, Jing Wang, Yi Zou, Jiahao Liu, Christie Bialowas, Hairong Luo, Yacheng Zhang, Bilian Liu, Jingjing Zhang, Fang Hu, Meilian Liu, Lily Q. Dong, Zhiguang Zhou, Feng Liu, Juli Bai   +18 more
doaj   +1 more source

Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes. [PDF]

PLoS Pathogens, 2015
Acetylcholine receptors are pentameric ligand-gated channels involved in excitatory neuro-transmission in both vertebrates and invertebrates. In nematodes, they represent major targets for cholinergic agonist or antagonist anthelmintic drugs. Despite the
Elise Courtot, Claude L Charvet, Robin N Beech, Abdallah Harmache, Adrian J Wolstenholme, Lindy Holden-Dye, Vincent O'Connor, Nicolas Peineau, Debra J Woods, Cedric Neveu   +9 more
doaj   +1 more source

Contrary effects of the gut metabolites deoxycholate and butyrate on the acetylcholine-evoked calcium response in an enteroendocrine cell model

Endocrine and Metabolic Science
The interaction of nutrients and bacterial-derived products and their enteroendocrine effects are still enigmatic. We used the human enteroendocrine tumour cell line P-STS isolated from the terminal ileum as cellular sentinel.
Beatrix Pfanzagl, Erika Jensen-Jarolim
doaj   +1 more source

Localization of muscarinic acetylcholine receptor 2 to the intestinal crypt stem cell compartment

Data in Brief, 2017
The data presented in this article are related to the research article entitled “Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine” (E.D. Muise, N. Gandotra, J.J. Tackett, M.C. Bamdad, R.A. Cowles, 2016) [1].
Eleanor D. Muise, Neeru Gandotra, John J. Tackett, Michaela C. Bamdad, Robert A. Cowles   +4 more
doaj   +1 more source

New insight into the tick neuronal nicotinic acetylcholine receptors: from molecular to pharmacological studies

Ticks and Tick-Borne Diseases
ACh is known to be an excitatory neurotransmitter in the central nervous system of several arthropod species. Nicotinic acetylcholine receptors are involved in rapid neurotransmission and are the target of compounds used as acaricides.
Khalid Boussaine, Philippine Chartier, Alison Cartereau, Daniel Auguin, Emiliane Taillebois, Steeve H. Thany   +5 more
doaj   +1 more source

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +1 more source

Efficacy of atopic dermatitis alleviation through transcutaneous auricular vagus nerve stimulation in 2,4-dinitrochlorobenzene (DNCB)-induced mouse model

Annals of Medicine
Background Atopic dermatitis (AD) commonly begins in early childhood, and non-pharmacological treatment options remain limited. Vagal cholinergic signaling can modulate immune responses, suggesting a potential role for neuromodulation in inflammatory ...
Chan Mi Lee, Jae Hee Shin, Jae-Jun Song
doaj   +1 more source

Molecular Biological Mechanisms of Yuan Zhi Powder in the Treatment of Alzheimer’s Disease: an Analysis Based on Network Pharmacology

Digital Chinese Medicine, 2018
: Objective To predict the main active ingredients, potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by ...
Wei-Jie Qiang, Ying Chen, Fu-Yuan He, Mei-Feng Xiao, Wei-Yan Cai, Yi-Fei Dai, Qing Yang, Yu-Jie Li, Xiao-Gang Weng, Qi Li, Ya-Jie Wang, Xiao-Xin Zhu   +11 more
doaj   +1 more source

Muscarinic receptor signaling in the pathophysiology of asthma and COPD

Respiratory Research, 2006
Anticholinergics are widely used for the treatment of COPD, and to a lesser extent for asthma. Primarily used as bronchodilators, they reverse the action of vagally derived acetylcholine on airway smooth muscle contraction.
Zaagsma Johan, Gosens Reinoud, Meurs Herman, Halayko Andrew J   +3 more
doaj   +1 more source