Results 191 to 200 of about 116,451 (242)
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Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1975
a-Bungarotoxin is one of a class of proteins, isolated from snake venoms, which antagonize the action of acetylcholine at vertebrate neuromuscular junctions and ‘electroplaques' of electric fish. a-Bungarotoxin blocks acetylcholine action irreversibly and may be labelled with either 125 I or 3
D P, Green +3 more
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a-Bungarotoxin is one of a class of proteins, isolated from snake venoms, which antagonize the action of acetylcholine at vertebrate neuromuscular junctions and ‘electroplaques' of electric fish. a-Bungarotoxin blocks acetylcholine action irreversibly and may be labelled with either 125 I or 3
D P, Green +3 more
openaire +2 more sources
Trends in Pharmacological Sciences, 1979
Neurons communicate with their target cells mostly by chemical means. The molecules involved, neurotransmitters. are in general small molecules which are liberated by nerve terminals upon rapid variation of the membrane potential. The ch.ange of neurotransmitter concentration in the synapse with time constitutes the ‘signal’ for inter-cellular ...
Jean-Pierre Changeux, J. Giraudat
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Neurons communicate with their target cells mostly by chemical means. The molecules involved, neurotransmitters. are in general small molecules which are liberated by nerve terminals upon rapid variation of the membrane potential. The ch.ange of neurotransmitter concentration in the synapse with time constitutes the ‘signal’ for inter-cellular ...
Jean-Pierre Changeux, J. Giraudat
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Muscarinic Acetylcholine Receptors
Current Pharmaceutical Design, 2006Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru Ishii, Yoshihisa Kurachi
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The biochemistry of an acetylcholine receptor
Journal of Supramolecular Structure, 1974AbstractThe acetylcholine receptor from Torpedo californica electroplax has been studied at three levels of molecular organization: receptor‐rich membrane fragments, solubilized and purified receptor, and reconstituted receptor in phospholipid vesicles.
Michael A. Raftery +8 more
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Muscarinic acetylcholine receptor
Progress in Neurobiology, 1978ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
Edith Heilbronn, Tamas Bartfai
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Quarterly Reviews of Biophysics, 1974
The idea that certain drugs and neurotransmitters produce their effects by combining with specific receptors was first clearly expressed by Langley (1905) on the basis of the selective and localized effect of nicotine on striated muscle fibres. In 1914, Langley published a paper in which the antagonism between ‘curari’ and nicotine ...
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The idea that certain drugs and neurotransmitters produce their effects by combining with specific receptors was first clearly expressed by Langley (1905) on the basis of the selective and localized effect of nicotine on striated muscle fibres. In 1914, Langley published a paper in which the antagonism between ‘curari’ and nicotine ...
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Isolation of Acetylcholine Receptors
Annual Review of Pharmacology, 1972When ACh acts in an excitatory way, it increases the conductance of a post-synaptic membrane for Na+ and K+, leading to membrane depolariza tion. We shall use the term acetylcholine receptor (AChR) for those ma cromolecules involved in this transduction that bear the recognition site( s) for ACh and other cholinergic ligands.
R D O'Brien +2 more
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