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Muscarinic acetylcholine receptor from rat brain. Partial purification and characterization.
Pēteris Alberts, Tamás Bartfai
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Acetylcholine-receptor-mediated ion flux in electroplax membrane preparations.
George P. Hess+3 more
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Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1975
a-Bungarotoxin is one of a class of proteins, isolated from snake venoms, which antagonize the action of acetylcholine at vertebrate neuromuscular junctions and ‘electroplaques' of electric fish. a-Bungarotoxin blocks acetylcholine action irreversibly and may be labelled with either 125 I or 3
D P, Green+3 more
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a-Bungarotoxin is one of a class of proteins, isolated from snake venoms, which antagonize the action of acetylcholine at vertebrate neuromuscular junctions and ‘electroplaques' of electric fish. a-Bungarotoxin blocks acetylcholine action irreversibly and may be labelled with either 125 I or 3
D P, Green+3 more
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α7-nicotinic acetylcholine receptor agonists for cognitive enhancement in schizophrenia.
Annual Review of Medicine, 2014α7-Nicotinic acetylcholine receptors have emerged as a potential therapeutic target for the treatment of neurocognitive dysfunctions in schizophrenia that are often resistant to existing antipsychotic drugs.
R. Freedman
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Trends in Pharmacological Sciences, 1979
Neurons communicate with their target cells mostly by chemical means. The molecules involved, neurotransmitters. are in general small molecules which are liberated by nerve terminals upon rapid variation of the membrane potential. The ch.ange of neurotransmitter concentration in the synapse with time constitutes the ‘signal’ for inter-cellular ...
Jean-Pierre Changeux, J. Giraudat
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Neurons communicate with their target cells mostly by chemical means. The molecules involved, neurotransmitters. are in general small molecules which are liberated by nerve terminals upon rapid variation of the membrane potential. The ch.ange of neurotransmitter concentration in the synapse with time constitutes the ‘signal’ for inter-cellular ...
Jean-Pierre Changeux, J. Giraudat
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Muscarinic Acetylcholine Receptors
Current Pharmaceutical Design, 2006Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru Ishii, Yoshihisa Kurachi
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The biochemistry of an acetylcholine receptor
Journal of Supramolecular Structure, 1974AbstractThe acetylcholine receptor from Torpedo californica electroplax has been studied at three levels of molecular organization: receptor‐rich membrane fragments, solubilized and purified receptor, and reconstituted receptor in phospholipid vesicles.
Michael A. Raftery+8 more
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Nicotinic acetylcholine receptor agonists: a milestone for modern crop protection.
Angewandte Chemie, 2013The destruction of crops by invertebrate pests is a major threat against a background of a continuously rising demand in food supply for a growing world population.
P. Jeschke, R. Nauen, M. E. Beck
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Muscarinic acetylcholine receptor
Progress in Neurobiology, 1978ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
Edith Heilbronn, Tamas Bartfai
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Quarterly Reviews of Biophysics, 1974
The idea that certain drugs and neurotransmitters produce their effects by combining with specific receptors was first clearly expressed by Langley (1905) on the basis of the selective and localized effect of nicotine on striated muscle fibres. In 1914, Langley published a paper in which the antagonism between ‘curari’ and nicotine ...
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The idea that certain drugs and neurotransmitters produce their effects by combining with specific receptors was first clearly expressed by Langley (1905) on the basis of the selective and localized effect of nicotine on striated muscle fibres. In 1914, Langley published a paper in which the antagonism between ‘curari’ and nicotine ...
openaire +2 more sources