Results 51 to 60 of about 2,529,430 (407)

Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. [PDF]

, 1980
Protease digestion of acetylcholine receptor-rich membranes derived from Torpedo californica electroplaques by homogenization and isopycnic centrifugation results in degradation of all receptor subunits without any significant effect on the appearance in
Heuser, JE, Klymkowsky, MW, Stroud, RM
core   +1 more source

End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease.

Physiological Reviews, 2012
The synapse is a localized neurohumoral contact between a neuron and an effector cell and may be considered the quantum of fast intercellular communication.
S. Sine
semanticscholar   +1 more source

Relaxation measurements on the acetylcholine receptor. [PDF]

Proceedings of the National Academy of Sciences, 1975
In Electrophorus electroplaques, the agonist-induced postsynaptic conductance depends on membrane potential. During steady exposure to agonists, after a voltage step the conductance relaxes on a millisecond time scale, exponentially approaching a new equilibrium value.
Sheridan, Robert E., Lester, Henry A.
openaire   +5 more sources

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay, E. Vichayanrat, F. Bremner, F. Valerio, R. Mackenzie, G. Chiaro, G. Ingle, P. McNamara, L. Watson, J. N. Panicker, M. P. Lunn, C. Mathias, V. Iodice   +12 more
wiley   +1 more source

Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice

Nature Communications
Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and
Quynh-Anh Nguyen, Peter M. Klein, Cheng Xie, Katelyn N. Benthall, Jillian Iafrati, Jesslyn Homidan, Jacob T. Bendor, Barna Dudok, Jordan S. Farrell, Tilo Gschwind, Charlotte L. Porter, Annahita Keravala, G. Steven Dodson, Ivan Soltesz   +13 more
doaj   +1 more source

The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor

Pharmacological Research, 2023
Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic receptors (nAChRs) were classically identified to mediate synaptic transmission in the nervous system and the neuromuscular junction. The α9 and α10 nAChR subunits were
Ana Belén Elgoyhen
doaj  

Erratum to: The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes

Protein & Cell, 2017
In the original publication of the article the keywords are incorrectly online published. The correct keywords should read as α-Conotoxin; Nicotinc acetylcholine receptor; Acetylcholine binding protein; X-ray crystallography”.
Manyu Xu, Xiaopeng Zhu, Jinfang Yu, Jinpeng Yu, Sulan Luo, Xinquan Wang   +5 more
doaj   +1 more source

Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophrenia.

American Journal of Psychiatry, 2012
OBJECTIVE There is a strong association between cigarette smoking and schizophrenia. Nicotine's actions in the brain are mediated through nicotinic acetylcholine receptors.
D. D’Souza, I. Esterlis, Michelle Carbuto, Maegan Krasenics, J. Seibyl, F. Bois, B. Pittman, M. Ranganathan, K. Cosgrove, J. Staley   +9 more
semanticscholar   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Anti-Kv1.4 Antibody Without Myasthenia Gravis

JACC: Case Reports, 2023
Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis.
Naoto Kuyama, MD, Seiji Takashio, MD, PhD, Takumi Nagakura, MD, Michie Imamura, MD, Koutaro Takamatsu, MD, PhD, Masafumi Takae, MD, PhD, Kyoko Hirakawa, MD, PhD, Kenshi Yamanaga, MD, PhD, Shinsuke Hanatani, MD, PhD, Eiichiro Yamamoto, MD, PhD, Kenichi Matsushita, MD, PhD, Mitsuharu Ueda, MD, PhD, Kenichi Tsujita, MD, PhD   +12 more
doaj