Results 131 to 140 of about 45,061 (213)

N-Acetylcysteine Attenuates Mancozeb-Induced Hepatorenal Injury by Modulating Oxidative Stress, Inflammatory Signaling, and Apoptotic Pathways in Rats. [PDF]

J Biochem Mol Toxicol
Çakırlı A, Karakoç MD, Özmen Ö, Kaplan MN, Çiftçi O.   +4 more
europepmc   +1 more source

Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers. [PDF]

Clin Pharmacol Ther
Acetaminophen overdose can cause liver injury. Hepatotoxicity results from N‐acetyl‐p‐benzoquinone imine (NAPQI), generated via cytochrome P450‐2E1 (CYP2E1). Acetylcysteine is the mainstay of treatment, but efficacy may be reduced with delayed administration or large ingestions.
Anand S, Buckley NA, Stathakis P, James L, Parker L, McGill MR, Chiew AL.   +6 more
europepmc   +2 more sources

Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management

MedComm, Volume 7, Issue 10, October 2026.
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley   +1 more source

N-acetylcysteine in Thrombotic Thrombocytopenic Purpura: A Systematic Review. [PDF]

Cureus
Talat F, Talpur AS, Sardar M, Solangi Z, Usman H, Ahmad A, Sardar A, Kallem M, Yalamanchili M.   +8 more
europepmc   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Dapsone and N-Acetylcysteine Exert a Synergistic Antinociceptive Effect Associated with Oxidative Stress After Traumatic Spinal Cord Injury: An Isobolographic Study. [PDF]

Brain Sci
Romero-Sánchez HA, Ríos C, Martínez-Cárdenas MLÁ, Navarro L, Moreno-Rocha LA, Mata-Bermudez A, Díaz-Ruiz A.   +6 more
europepmc   +1 more source

Drug‐Induced Liver Injury During Treatment With Tocilizumab: A Case Report of an Atypical Pattern Lesion

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Tocilizumab is an interleukin‐6 (IL‐6) receptor antagonist indicated for various rheumatologic conditions. While hepatotoxicity is a recognized adverse effect, it predominantly manifests as hepatocellular injury. We report a rare case of drug‐induced liver injury (DILI) presenting with a cholestatic pattern and cholangitis features in a 75 ...
Louis‐Edmond Barbaro, Nouha Ben Othman, Delphine Viard, Fanny Rocher, Elliot Ewig, Raja Mroue, Claire Amigues, Alexandre O. Gérard   +7 more
wiley   +1 more source

Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless, Riccardo Milazzo, Martin S. Bojer, Benjamin S. Sereika‐Bejder, Hanne Ingmer, Christian A. Olsen   +5 more
wiley   +2 more sources

Acetaminophen Overdose in an Extremely Low-Birth-Weight Premature Infant: A Case Report and Review of the Literature. [PDF]

Cureus
Pham A, Ohler K, Gimbar RP, Thompson TM, Pillers DA, Raghavan A.   +5 more
europepmc   +1 more source

Pathomechanism of Fever-Induced Liver Failure in NBAS Deficiency and Treatment Effect of NAC-Observations In Vitro and In Vivo. [PDF]

Liver Int
Sun T, Hammann N, Leghlam L, Peters B, Arikan C, Bedoyan SM, Chen Q, Dattner T, Distelmaier F, Fichtner A, Garbade SF, Hadžić N, Hegarty R, Hellwig A, Jørgensen MH, Jentsch C, Jung-Klawitter S, Laass M, Lainka E, Münch H, Mungan HNÖ, Niesert M, Oehrl S, Polo B, Schäkel K, Squires JE, Kölker S, Hoffmann GF, Staufner C, Lenz D.   +29 more
europepmc   +1 more source