Results 131 to 140 of about 43,453 (230)

N-acetylcysteine alleviates experimental autoimmune prostatitis in rats by activating PI3K/Akt/CREB and Keap1/Nrf2 pathways. [PDF]

Transl Androl Urol
Wu C, Fu F, Xiong Y, Qin F, Liu Y, Yuan J.   +5 more
europepmc   +1 more source

Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 795-805, September 2026.
Acetaminophen overdose can cause liver injury. Hepatotoxicity results from N‐acetyl‐p‐benzoquinone imine (NAPQI), generated via cytochrome P450‐2E1 (CYP2E1). Acetylcysteine is the mainstay of treatment, but efficacy may be reduced with delayed administration or large ingestions.
Sidharth Anand, Nicholas A. Buckley, Paul Stathakis, Laura James, Larry Parker, Mitchell R. McGill, Angela L Chiew   +6 more
wiley   +1 more source

Unraveling the complex role of intestinal microbiota in drug permeability: Insights from N-acetylcysteine. [PDF]

Asian J Pharm Sci
Tian C, He Z.
europepmc   +1 more source

Dedicated Endoscopy for Barrett's Oesophagus With Higher Dysplasia Yield May Reduce Seattle Protocol Biopsies: Results From UK Multicentre Study

United European Gastroenterology Journal, Volume 14, Issue 7, September 2026.
ABSTRACT Background Dedicated service for Barrett's oesophagus (BO) surveillance may be more effective than conventional service, according to some single centre studies. Objective To determine whether the surveillance of BO through a dedicated service can improve key performance indicators (KPIs), and dysplasia detection rate (DDR) compared with ...
Champika Gamakaranage, James Britton, Elizabeth Ratcliffe, Neeraj Prasad, Richard Keld, Mark Murgatroyd, Shanmugasundaram Balakrishnan, Nazar Aslam, Vinay Sehgal, Jenni Marsh, Daniel Plant, Matthew Johnston, Stefanos Kateroglou, Jake Baker, Hannah Morgan, Claudia Cipriano, Anjan Dhar, Shaheen Hamdy, John McLaughlin, Yeng Ang, on behalf ofDEBO group   +20 more
wiley   +1 more source

Intrinsic Acidity of N-Acetylcysteine Mediates Enhanced Inhibition of <i>Klebsiella pneumoniae</i> and Its Biofilms by Polymyxin B. [PDF]

Microorganisms
Wang F, Wang W, Gu H.
europepmc   +1 more source

ROS‐Responsive Nanobubbles for Dual‐Enhanced Ultrasound and Magnetic Resonance Imaging of Tumor Oxidative Stress

Advanced Science, Volume 13, Issue 44, 7 August 2026.
We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung, Youngju Son, Dong Yun Lee, Youngeun Jeon, Muhammad Asaddudin, Sung‐Hong Park, Sangyong Jon   +6 more
wiley   +1 more source

Correction: Vitexin compound 1, a novel extraction from a Chinese herb, suppresses melanoma cell growth through DNA damage by increasing ROS levels. [PDF]

J Exp Clin Cancer Res
Liu N, Wang KS, Qi M, Zhou YJ, Zeng GY, Tao J, Da Zhou J, Zhang JL, Chen X, Peng C.   +9 more
europepmc   +1 more source

Engineered Carbon Dots from a Traditional Herb Pair Orchestrate Concurrent Antioxidant and AP‐1‐Mediated Inflammation to Attenuate Renal Ischemia‐Reperfusion Injury

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study integrates two complementary traditional Chinese medicine components as precursors to synthesize bioactive AM‐AS@CDs. Compared with single‐component CDs, these dual‐component CDs exhibit enhanced antioxidant capacity and superior renoprotective effects.
Bixiao Liu, Fuying Zhu, Zhuqing Wang, Jiawen Chen, Xiaomiao Cui, Congzhong Yang, Yao Peng, Dengyuan Feng, Li Lu, Hui Wei, Xiaozhi Zhao   +10 more
wiley   +1 more source

Mucolytic Core-Shell Particles to Boost Levofloxacin Penetration Through the Mucus Barrier in Cystic Fibrosis. [PDF]

Pharm Res
Ruggiero V, Mariano F, Larobina D, D'Avino G, Trofa M, Tedesco C, Del Gaudio P, Russo P.   +7 more
europepmc   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source