Results 111 to 120 of about 40,317 (191)

Evolution of Thiosemicarbazones: From First‐ to Second‐Generation Metal Chelators and Their Reactive Oxygen Species‐Mediated Effects in Melanoma

ChemistryOpen, Volume 15, Issue 6, June 2026.
Thiosemicarbazones (TSC) have demonstrated promise as new chemotherapeutic agents against melanoma in both in vitro and In vivo studies. TSC are powerful metal coordinating agents, coordinating transition metal ions such as zinc, copper and iron in multiple oxidation states. It is this metal coordination that imparts the anticancer activity.
Rohina Alim, Scott D. Andrew, Christopher J. Parkinson   +2 more
wiley   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Sola Akinbolade, Rhiannon Potter, Alex Inskip, Jane Nesworthy, Kirsti Brock, Gill Norman   +5 more
wiley   +1 more source

N-Acetylcysteine Dose and Treatment Duration in High-Risk Acetaminophen Ingestions Treated Within Eight Hours: A Retrospective Cohort Study. [PDF]

J Med Toxicol
Watson CJ, Simpson MD, Saraiya N, Wilkosz CA, Yu MB, Burns MM, Neavyn MJ, Simone KE, Strout TD.   +8 more
europepmc   +1 more source

Non-Mineral Antioxidant Supplementation in Endometriosis: Biological Rationale, Clinical Evidence, and Therapeutic Implications-A Narrative Review. [PDF]

Nutrients
Pokorska-Niewiada K, Janda-Milczarek K, Kayumov K, Ziętek M, Szczuko M.   +4 more
europepmc   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, Volume 31, Issue 6, Page 561-577, June 2026.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Investigation of Contrast-Induced Neurotoxicity and the Effects of Sildenafil and <i>N</i>-Acetylcysteine on HIF-1α Levels in Wistar Rats. [PDF]

Brain Sci
Altintop I, Tatli M, Sarica ZS, Yay AH, Karakukcu Ç.   +4 more
europepmc   +1 more source

Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1‐STING Inflammatory Axis

Smart Medicine, Volume 5, Issue 3, June 2026.
Magnetic fields modulate macrophage‐cancer crosstalk through the STING‐TRPC1 axis. Exposure reprograms macrophages toward the anti‐cancer phenotype. Exposing cancer cells modulates cancer secretome to promote polarization and selective recruitment of M1‐tumoricidal macrophages, enhancing cancer immunogenicity.
Viresh Krishnan Sukumar, Yee Kit Tai, Jan Nikolas Iversen, Olivia Yeo, Anisha Praiselin Paul, Kwan Yu Wu, Lina Hsiu Kim Lim, Alfredo Franco‐Obregón   +7 more
wiley   +1 more source

Tumor cell membrane camouflaged liposomal pharmaceuticals for cascade catalysis‐driven redox modulation and synergistic ROS/RNS antitumor therapy

VIEW, Volume 7, Issue 3, June 2026.
A tumor cell membrane camouflaged liposomal nanoplatform (C‐MLip@LA) modulates tumor redox homeostasis to enhance targeted therapy. By encapsulating L‐arginine, anchoring MnO2 nanoparticles, and leveraging homologous membrane‐mediated specificity, C‐MLip@LA efficiently triggers a synergistic ROS/RNS cascade, amplifies immunogenic cell death, and ...
Guangrong Zheng, Tengfei Ke, Hongjin Wang, Hong Huang, Ying Zhang, Guanghai Fei, Chengde Liao, Haiyan Yang   +7 more
wiley   +1 more source

D-salicin induces oxidative stress-mediated ERK1/2 suppression and apoptosis in endometrial cancer cells. [PDF]

Oncol Lett
Ari NS, Çakir Gündoğdu A.
europepmc   +1 more source

Oxidative Stress and Diminished Mitochondrial Proteostatic Reserve Are Linked to Enhanced mtUPR Initiation in Aged Mouse Muscle

Aging Cell, Volume 25, Issue 6, June 2026.
Aged mouse skeletal muscle exhibits greater mtUPR transcriptional initiation following repeated physical stress than young mice, coinciding with reduced mitochondrial proteostatic reserve and heightened oxidative burden. We implicate a mtROS‐JNK‐CHOP axis as a contributor to the enhanced response.
Grant R. Laskin, Baylah R. Mazonson, LaDora V. Thompson   +2 more
wiley   +1 more source