Results 111 to 120 of about 79,020 (262)

Cough in children with acute respiratory infections: to treat or not to treat?

Лечащий Врач, 2021
The article discusses the methods of therapeutic influence in the case of transport disorders and improvement of the drainage functions of the respiratory tract in acute respiratory infections in children. The mechanism of action of acetylcysteine in the
O. I. Simonova, K. A. Ikonnikova
doaj  

A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy [PDF]

, 2015
Acute and chronic pain often requires a multimodal approach. Combination therapy reduces the number of individual daily administrations and improves patient's compliance with the prescribed analgesic treatment. Despite the association codeine/paracetamol
COLUZZI, FLAMINIA, MATTIA, Consalvo
core  

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

Evaluation of topical n-acetylcysteine in diversion colitis

Journal of Coloproctology, 2012
INTRODUCTION: Diversion colitis (DC) is a benign condition characterized by the appearance of inflammation in the mucosa of the colon or rectum devoid of fecal stream. Oxidative stress has been associated with the etiopathogenesis of the disease.
Marcos Gonçalves de Almeida, José Aires Pereira, Canila Morais Gonçalves da Silva, Fernando Lorenzetti da Cunha, Letícia Helena de Sousa Marques, Thais Miguel do Monte Lameiro, Carlos Augusto Real Martinez   +6 more
doaj  

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Restoration of Immune Surveillance in Prostate Cancer Prevention by Sulforaphane in Hi‐Myc Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Oral administration of broccoli constituent sulforaphane (SFN) prevents prostate cancer development in preclinical mouse models. However, the mechanism(s) underlying prostate cancer prevention by SFN are not fully understood. In this study, we used a human relevant mouse model (Hi‐Myc mice) to demonstrate restoration of immune surveillance by ...
Krishna B. Singh, Eun‐Ryeong Hahm, Joshi J. Alumkal, Shivendra V. Singh   +3 more
wiley   +1 more source

Antimicrobial and Antibiofilm Activity of Auranofin and Its Two Derivatives Bearing Naproxen and Acetylcysteine as Ligands Against Staphylococci

Antibiotics
Background/Objectives: The ability of bacteria to form biofilms makes them more tolerant to traditional antibiotics. Given the lack of new antibiotic development, drug repurposing offers a strategy for discovering new treatments.
Caterina Ferretti, Lorenzo Chiaverini, Noemi Poma, Andrea Dalli, Riccardo Di Leo, Laura Rindi, Alessandro Marrone, Iogann Tolbatov, Diego La Mendola, Arianna Tavanti, Tiziano Marzo, Mariagrazia Di Luca   +11 more
doaj   +1 more source

Complementary and Integrative Medicine for the Treatment of Tourette's Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background There is widespread interest in complementary and integrative medicine (CIM) among people with Tourette's syndrome (TS). Objective To perform a systematic review of evidence on the use of CIM to reduce tics and improve tic‐related quality of life.
Tamara Pringsheim, Catherine Deans, Saar Anis, Poonam Bhatia, Kevin Black, Yildiz Degirmenci, Donald Gilbert, Andreas Hartmann, Mariam Hull, Irene Malaty, Davide Martino, Alex Medina Escobar, Pablo Mir, Christelle Nilles, Marianna Sarchioto, Jibrin Sammani Usman, Harini Sarva, Katarzyna Smilowksa, Natalia Szejko, Kinga Tomczak, Daniel van Wamelen, Yulia Worbe   +21 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source