Results 161 to 170 of about 43,453 (230)

Complex Contributions of Methylglyoxal to Pain, Axon Degeneration, and Diabetic Peripheral Neuropathy

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
This work reviews how the metabolic by‐product methylglyoxal may contribute to the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes characterized by nerve damage and chronic pain in the extremities. In diabetes, methylglyoxal levels rise due to increased glucose metabolism and reduced detoxification capacity. While
Gentry Totta‐Griese, Douglas E. Wright
wiley   +1 more source

N-Acetylcysteine Dose and Treatment Duration in High-Risk Acetaminophen Ingestions Treated Within Eight Hours: A Retrospective Cohort Study. [PDF]

J Med Toxicol
Watson CJ, Simpson MD, Saraiya N, Wilkosz CA, Yu MB, Burns MM, Neavyn MJ, Simone KE, Strout TD.   +8 more
europepmc   +1 more source

Pathomechanism of Fever‐Induced Liver Failure in NBAS Deficiency and Treatment Effect of NAC—Observations In Vitro and In Vivo

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background and Aims Pathogenic variants in neuroblastoma amplified sequence (NBAS) gene causes infantile liver failure type 2 (IFLS2; MIM 616483), characterised by recurrent episodes of liver failure triggered by febrile infections. The underlying pathophysiological mechanisms remain incompletely understood. With this work we try to shed light
Tian Sun, Nicole Hammann, Lina Leghlam, Bianca Peters, Cigdem Arikan, Sarah M. Bedoyan, Qian Chen, Tal Dattner, Felix Distelmaier, Alexander Fichtner, Sven F. Garbade, Nedim Hadžić, Robert Hegarty, Andrea Hellwig, Marianne Hørby Jørgensen, Carolin Jentsch, Sabine Jung‐Klawitter, Martin Laass, Elke Lainka, Hannah Münch, Halise Neslihan Önenli Mungan, Moritz Niesert, Stephanie Oehrl, Begona Polo, Knut Schäkel, James E. Squires, Stefan Kölker, Georg F. Hoffmann, Christian Staufner, Dominic Lenz   +29 more
wiley   +1 more source

Epstein-Barr Virus (EBV) Hepatitis Treated With N-Acetylcysteine: Placebo Versus True Effect. [PDF]

Cureus
Ahl A, Abadir S, Kalfayan G, Desai K.
europepmc   +1 more source

Long‐term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats

Experimental Physiology, Volume 111, Issue 8, Page 3667-3683, 1 August 2026.
Abstract Cocoa shell extract (CSE; rich in antioxidant compounds) administered to adult hypertensive rats exposed to fetal undernutrition (MUN) reduces blood pressure, improving cardiovascular alterations. We aimed to explore lactation as a reprogramming window, evaluating the long‐term effects of CSE supplementation during this period. MUN and control
Santiago Ruvira, Pilar Rodríguez‐Rodríguez, Metee Iampanichakul, Begoña Quintana‐Villamandos, Dolores Morales, David Ramiro‐Cortijo, Silvia M. Arribas   +6 more
wiley   +1 more source

Cobinamide, a Vitamin B₁₂ Analog, Attenuates Benzo[a]pyrene and Pyrene Toxicity Through Selective Redox Modulation. [PDF]

Toxics
Kalyanaraman A, Stauffer CB, Gao W, Zhong T, Nguyen A, Casteel DE, Pilz RB, Boss GR, Kalyanaraman H, Tat J.   +9 more
europepmc   +1 more source

N-Acetylcysteine Reduces Tissue Injury Induced by Oxygen-Glucose Deprivation in an Organotypic Culture of Mouse Cerebral Cortex Slices. [PDF]

Children (Basel)
Villani C, Di Clemente A, Invernizzi RW, Rezzonico R.   +3 more
europepmc   +1 more source

Longitudinal craving profiles in cannabis use disorder: A latent class growth analysis of the achieving cannabis cessation: Evaluating N-Acetylcysteine Treatment (ACCENT) (CTN-0053) trial. [PDF]

Drug Alcohol Depend
Alias-Ferri M, Flesaker M, Gray K, Tomko R, McPherson S, Korthuis PT, Humphreys K, Moran L, Timko C, Vest N.   +9 more
europepmc   +1 more source

N-Acetylcysteine Prevents Arsenic-Induced Apoptosis but Not Supernumerary Motor Neuron Development in Zebrafish Embryos: Assessment of Protein Carbonylation and the p53 Pathway. [PDF]

Int J Mol Sci
Gu Q, Silva CS, Twaddle NC, Beland FA, Kanungo J.   +4 more
europepmc   +1 more source

Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults. [PDF]

Front Nutr
Wang X, Hou R, Chen Z, Wang X, Wang H.
europepmc   +1 more source