Results 191 to 200 of about 83,041 (240)

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

New Cellular Interactions Due to the Radioprotective Effect of N-Acetylcysteine in a Model of Radiation-Induced Pancreatitis. [PDF]

Int J Mol Sci
Demyashkin G, Vadyukhin M, Shchekin V, Borovaya T, Zavialova O, Belokopytov D, Silakov K, Shegay P, Kaprin A.   +8 more
europepmc   +1 more source

Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease

, 2001
Marek Kasielski, Dariusz Nowak
openalex   +1 more source

Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

Advanced Science, Volume 12, Issue 40, October 27, 2025.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng, Songying Ouyang   +13 more
wiley   +1 more source

Trends in Fomepizole Use for Acetaminophen Poisoning in the United States; 2013-2024. [PDF]

J Med Toxicol
D'Aloia M, Smith D, Boley R, Schamber E, Thorpe D, Thompson TM, Chhabra N.   +6 more
europepmc   +1 more source

Multifunctional NIR‐Triggered Nanozyme‐Based Microneedles for Synergistic Eradication of MRSA and Enhanced Wound Healing

Advanced Science, Volume 12, Issue 38, October 13, 2025.
The novel microneedle patches (MN@CTB) are fabricated by integrating CTB nanozymes into HAMA and PVA solution based on a photo‐crosslinking reaction. The MN@CTB microneedle patches present an excellent photothermal effect and NIR‐stimulated release of NO, which is advantageous for the elimination of MRS.
Wei Qian, Ruixi Li, Xiyan Zheng, Yingliang Li, Haiwei Xiong, Ye Zhang, Dengliang Lei, Qingfeng Shi, Yufeng Xie, Yiting Zhou, Bailong Tao, Kuai Yu, Aiping Le, Boxuan Zhou   +13 more
wiley   +1 more source

Redox imbalance and immune functions: opposite effects of oxidized low‐density lipoproteins and N‐acetylcysteine

, 2001
Marina Viora, Maria Giovanna Quaranta, Elisabetta Straface, Rosaria Varı́, Roberta Masella, Walter Malorni   +5 more
openalex   +2 more sources

Genomic Analysis of Trichotillomania

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 7, Page 120-125, October 2025.
ABSTRACT Trichotillomania (TTM) is a psychiatric condition in which people feel an overwhelming urge to pull out their hair, resulting in noticeable hair loss and significant distress. Twin and family studies suggest that TTM is at least partly genetic, but no genome‐wide analyses have been completed.
Matthew W. Halvorsen, Melanie E. Garrett, Michael L. Cuccaro, Allison E. Ashley‐Koch, James J. Crowley   +4 more
wiley   +1 more source

Therapeutic outcomes and inflammatory modulation of inhaled N-acetylcysteine bronchoalveolar lavage in severe pneumonia. [PDF]

Am J Transl Res
Long S, Qin H, Guo J, Liu L.
europepmc   +1 more source

Impact of Dietary Antioxidant Supplements on Atrophic Lesion Progression in Stargardt Disease: A Retrospective Observational Study. [PDF]

J Ophthalmol
Turski CA, Georgiou M, Puente CE, Sarici K, Zhou X, Maldonado RS.   +5 more
europepmc   +1 more source