Results 21 to 30 of about 43,453 (230)

Chromon-3-aldehyde derivatives restore mitochondrial function in rat cerebral ischemia [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): This work aimed to assess the effect of 10 new chromon-3-aldehyde derivatives on changes of mitochondrial function under the conditions of brain ischemia in rats.
Dmitry Pozdnyakov, Andrey Voronkov, Victoriya Rukovitsyna   +2 more
doaj   +1 more source

The Potential Use of Metformin, Dipyridamole, N-Acetylcysteine and Statins as Adjunctive Therapy for Systemic Lupus Erythematosus

Cells, 2019
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune condition that can potentially affect every single organ during the course of the disease, leading to increased morbidity and mortality, and reduced health-related quality of life ...
Marcus Kai Xuan Tan, Thurston Yan Jia Heng, Anselm Mak   +2 more
doaj   +1 more source

Protective Effect of N-Acetyl Cysteine on Chlorpyrifos-Induced Testicular Toxicity in Mice [PDF]

International Journal of Fertility and Sterility, 2019
Background Chlorpyrifos (CPF), an organophosphate pesticide, is widely used in farms in order to preserve crops and fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system.
Rasoul Kheradmandi, Seyed Gholam Ali Jorsaraei, Farideh Feizi, Ali Akbar Moghadamnia, Nahid Neamati   +4 more
doaj   +1 more source

Anti-Inflammatory Effect of Acetylcysteine and Royal Jelly against Fluoxetine-Induced Hepatotoxicity in Rats [PDF]

International Journal of Nutrition Sciences
Background: Hepatic toxicity of antipsychotic drugs needs to be protected by hepatoprotective medications. This study evaluated the antiinflammatory effect of N-acetylcysteine (NAC) and Royal jelly against hepatotoxicity of fluoxetine in rats.Methods ...
Azad Nahy, Manal Ibrahim, Manal ALhayder
doaj   +1 more source

Metagenomic Sequencing Analysis of the Effects of Acetylcysteine on the Pig Gut Microbiome

Microbiology Research, 2023
The gut microbiota is engaged in multiple interactions affecting host health, and gut dysbiosis can lead to many diseases. However, the effects of acetylcysteine (NAC) on the gut microbiome composition in pigs using metagenomic sequencing have not been ...
Shulin Fu, Xinyue Tian, Jingyang Li, Yuzhen Yuan, Jing He, Chun Peng, Ling Guo, Chun Ye, Yu Liu, Bingbing Zong, Yinsheng Qiu   +10 more
doaj   +1 more source

Perfil epidemiológico de pacientes intoxicados con acetaminofén con intenciones suicidas

Medicina U.P.B., 2022
Objetivo: este estudio busca describir los individuos evaluados por sobredosis de acetaminofén entre 2019 y 2020 en un centro de referencia de trasplante hepático en Colombia.
Daniel Vásquez, Luisa Fernanda Ahunca, Diana Restrepo, Marle Duque, Lina María Ramírez, Luis Guillermo Toro   +5 more
doaj   +1 more source

Seizure after a massive infusion of N-acetylcysteine and successful treatment with a good outcome

Journal of Emergency Practice and Trauma, 2022
Objective:N-acetylcysteine is frequently used as an efficacious antidote for acetaminophen toxicity. It prevents liver injury induced by paracetamol and in most cases the overdose of acetylcysteine produces mild clinical effects.
Khadijeh Saravani, Pantea Ramezannezhad, Mohammad Hossien Kamaloddini, Mohammadmahdi Akbari, Tayebeh Shahraki   +4 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source