Results 11 to 20 of about 459 (131)
A biologically active peptide mimetic of N-acetylgalactosamine/galactose [PDF]
BMC Research Notes, 2009 Background Glycosylated proteins and lipids are important regulatory factors whose functions can be altered by addition or removal of sugars to the glycan structure.
Hoober J Kenneth, Eggink Laura L
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Liver-Targeted Delivery of Oligonucleotides with N‑Acetylgalactosamine Conjugation [PDF]
ACS Omega, 2021 The potential therapeutic application of oligonucleotides (ONs) that selectively suppress target genes through antisense and RNA interference mechanisms has attracted great attention. The clinical applications of ONs have overcome multiple obstacles and become one of the most active areas for the development of novel therapeutics.
Hao Cui +4 more
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Development of Triantennary N‑Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins [PDF]
ACS Central Science, 2021 Targeted protein degradation (TPD) technology has drawn significant attention from researchers in both academia and industry. It is rapidly evolved as a new therapeutic modality and also a useful chemical tool in selectively depleting various protein targets.
Yaxian Zhou +4 more
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ENZYMATIC FORMATION OF ACETYLGALACTOSAMINE
Journal of Biological Chemistry, 1957 1 The following abbreviations are used : UDP for uridine ...
Cardini, Carlos E. +1 more
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The Molecular Architecture of Human N-Acetylgalactosamine Kinase [PDF]
Journal of Biological Chemistry, 2005 Galactokinase plays a key role in normal galactose metabolism by catalyzing the conversion of alpha-d-galactose to galactose 1-phosphate. Within recent years, the three-dimensional structures of human galactokinase and two bacterial forms of the enzyme have been determined.
James B, Thoden, Hazel M, Holden
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Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs
Disease Models & MechanismsABSTRACT The ability to prevent hepatocellular carcinoma (HCC) in patients with chronic liver disease remains an unmet clinical need. We performed a head-to-head comparison of N-acetylgalactosamine (GalNAc)-conjugated small interfering RNA (siRNA)-mediated inhibition of five genes (CDK1, PD-L1, CTNNB1, SMYD3, ANLN) to prevent cancer in ...
Gianna Maggiore +10 more
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Loss of perineuronal net N-acetylgalactosamine in Alzheimer’s disease [PDF]
Acta Neuropathologica, 2005 The perineuronal net (PN), a specialised region of extracellular matrix, is interposed between the neuronal cell surface and astrocytic processes. It is involved in the buffering of ions, in the development, stabilisation and remodelling of synapses and in the regulating the neuronal microenvironment particularly around the parvalbumin-positive ...
Baig, SM, Wilcock, GK, Love, S
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Molecules, 2023 UDP-Gal: glycoprotein-N-acetylgalactosamine β-1,3-galactosyltransferase (T-synthase, EC 2.4.1.122) catalyses the transfer of the monosaccharide galactose from UDP-Gal to GalNAc-Ser/Thr, synthesizing the core 1 mucin type O-glycan.
Marilica Zemkollari +3 more
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Parasite, 2016 The localization of carbohydrate terminals in Kudoa septempunctata ST3-infected muscle of olive flounder (Paralichthys olivaceus) was investigated using lectin histochemistry to determine the types of carbohydrate sugar residues expressed in Kudoa spores.
Kang Jaeyoun +4 more
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Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase
Nature Communications, 2018 The glycosyltransferase PglH transfers three terminal N-acetylgalactosamine (GalNAc) residues to a carrier, which is a prerequisite for bacterial protein N-glycosylation.
Ana S. Ramírez +6 more
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