The therapeutic prospects of N-acetylgalactosamine-siRNA conjugates [PDF]
Frontiers in Pharmacology, 2022 RNA interference has become increasingly used for genetic therapy following the rapid development of oligonucleotide drugs. Significant progress has been made in its delivery system and implementation in the treatment of target organs.
Lei Zhang +6 more
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Liver-Targeted Delivery of Oligonucleotides with N‑Acetylgalactosamine Conjugation [PDF]
ACS Omega, 2021 The potential therapeutic application of oligonucleotides (ONs) that selectively suppress target genes through antisense and RNA interference mechanisms has attracted great attention. The clinical applications of ONs have overcome multiple obstacles and become one of the most active areas for the development of novel therapeutics.
Hao Cui +4 more
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Development of Triantennary N‑Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins [PDF]
ACS Central Science, 2021 Targeted protein degradation (TPD) technology has drawn significant attention from researchers in both academia and industry. It is rapidly evolved as a new therapeutic modality and also a useful chemical tool in selectively depleting various protein targets.
Yaxian Zhou +4 more
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Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs [PDF]
Disease Models & MechanismsABSTRACT The ability to prevent hepatocellular carcinoma (HCC) in patients with chronic liver disease remains an unmet clinical need. We performed a head-to-head comparison of N-acetylgalactosamine (GalNAc)-conjugated small interfering RNA (siRNA)-mediated inhibition of five genes (CDK1, PD-L1, CTNNB1, SMYD3, ANLN) to prevent cancer in ...
Gianna Maggiore +10 more
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A biologically active peptide mimetic of N-acetylgalactosamine/galactose [PDF]
BMC Research Notes, 2009 Background Glycosylated proteins and lipids are important regulatory factors whose functions can be altered by addition or removal of sugars to the glycan structure.
Hoober J Kenneth, Eggink Laura L
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Genetic and functional diversity of β-N-acetylgalactosamine-targeting glycosidases expanded by deep-sea metagenome analysis [PDF]
Nature Communicationsβ-N-Acetylgalactosamine-containing glycans play essential roles in several biological processes, including cell adhesion, signal transduction, and immune responses.
Tomomi Sumida +9 more
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Expression and Characterisation of the First Snail-Derived UDP-Gal: Glycoprotein-N-acetylgalactosamine β-1,3-Galactosyltransferase (T-Synthase) from Biomphalaria glabrata [PDF]
Molecules, 2023 UDP-Gal: glycoprotein-N-acetylgalactosamine β-1,3-galactosyltransferase (T-synthase, EC 2.4.1.122) catalyses the transfer of the monosaccharide galactose from UDP-Gal to GalNAc-Ser/Thr, synthesizing the core 1 mucin type O-glycan.
Marilica Zemkollari +3 more
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Beilstein Journal of Organic Chemistry, 2018 Synthetic approaches towards N-acetylgalactosamine (GalNAc) have been attracting considerable interest since this compound is known for its pivotal role in cell–cell interaction and receptor induced cell signaling. Herein, we present a synthetic route in
Bettina Riedl, Walther Schmid
exaly +2 more sources
Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19 [PDF]
Frontiers in Microbiology, 2021 Human serum contains large amounts of anti-carbohydrate antibodies, some of which may recognize epitopes on viral glycans. Here, we tested the hypothesis that such antibodies may confer protection against COVID-19 so that patients would be preferentially
Adrien Breiman +14 more
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Exploring Multivalent Architectures for Binding and Stabilization of N-Acetylgalactosamine 6-Sulfatase [PDF]
MoleculesMorquio A syndrome is a lysosomal disorder caused by the deficiency of the lysosomal enzyme N-acetylgalactosamine 6-sulfatase (GALNS, EC 3.1.6.4).
Maria Giulia Davighi +8 more
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