Presence of N-acetylgalactosamine/galactose residues on bronchioloalveolar cells during rat postnatal development [PDF]
European Journal of Histochemistry, 2019 In mammals, the alveolarization process develops predominantly after birth. Airway cells display a complex assemblage of glycans on their surface. These glycans, particularly terminal glycan extensions, are important effective carriers of information ...
Maria de Fátima Martins +2 more
doaj +2 more sources
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus. [PDF]
J Biol Chem, 2019 يتم تنظيم الوظائف البيولوجية للبروتينات النووية من خلال تعديلات ما بعد الترجمة (PTMs) التي تعدل التعبير الجيني والفيزيولوجيا الخلوية. ومع ذلك، لم يتم الإبلاغ سابقًا عن دور الجليكوزيل المرتبط بـ O (O - GalNAc) باعتباره PTM للبروتينات النووية في الخلية البشرية. هنا، درسنا بالتفصيل بدء التخليق الحيوي O -GalNAc glycan، الذي يمثل PTM جديد للبروتينات النووية
Cejas RB +3 more
europepmc +5 more sources
Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications [PDF]
Neural Plasticity, 2016 Perineuronal nets (PNNs) are extracellular molecules that form around neurons near the end of critical periods during development. They surround neuronal cell bodies and proximal dendrites.
Adrienne L. Mueller +4 more
doaj +2 more sources
Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis. [PDF]
J Biol Chem, 2016 Glycan biosynthesis occurs mainly in Golgi. Molecular organization and functional regulation of this process are not well understood. We evaluated the extrinsic effect of lectin domains (β-trefoil fold) of polypeptide GalNAc-transferases (ppGalNAc-Ts) on catalytic activity of glycosyltransferases during O-GalNAc glycan biosynthesis.
Lorenz V +7 more
europepmc +6 more sources
Profound Impact of Decline in N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B) on Molecular Pathophysiology and Human Diseases [PDF]
International Journal of Molecular Sciences, 2022 Joanne Tobacman +2 more
exaly +2 more sources
Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain [PDF]
Nature Communications, 2018 Mammalian GPI membrane anchors are modified by GalNAc to confer structural diversity but the biosynthetic pathway is poorly understood. Here, the authors identify and characterize the Golgi-resident GPI-GalNAc transferase PGAP4, providing insights into ...
Tetsuya Hirata +11 more
doaj +2 more sources
Terminal N-acetylgalactosamine-specific leguminous lectin from Wisteria japonica as a probe for human lung squamous cell carcinoma. [PDF]
PLoS ONE, 2013 Millettia japonica was recently reclassified into the genus Wisteria japonica based on chloroplast and nuclear DNA sequences. Because the seed of Wisteria floribunda expresses leguminous lectins with unique N-acetylgalactosamine-binding specificity, we ...
Keisuke Soga +4 more
doaj +1 more source
Understanding Aspergillus fumigatus galactosaminogalactan biosynthesis: A few questions remain
The Cell Surface, 2023 Half a century after their discovery, polymers of N-acetylgalactosamine produced by the Aspergilli have garnered new interest as mediators of fungal virulence.
François Le Mauff, Donald C. Sheppard
doaj +1 more source
The Molecular Architecture of Human N-Acetylgalactosamine Kinase [PDF]
Journal of Biological Chemistry, 2005 Galactokinase plays a key role in normal galactose metabolism by catalyzing the conversion of alpha-d-galactose to galactose 1-phosphate. Within recent years, the three-dimensional structures of human galactokinase and two bacterial forms of the enzyme have been determined.
James B, Thoden, Hazel M, Holden
openaire +2 more sources
Characterization of a novel exonic deletion in the GALNS gene causing Morquio A syndrome
Molecular Genetics and Metabolism Reports, 2022 Mucopolysaccharidosis IVA or Morquio A syndrome is a rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase deficiency. A diagnosis can be provided by the identification of reduced N-acetylgalactosamine-6-sulfatase activity as well ...
Kathryn DeLong +4 more
doaj +1 more source