Results 51 to 60 of about 459 (131)
The FEBS Journal, EarlyView.Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal +5 more
wiley +1 more source
Insect Molecular Biology, EarlyView.Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto +2 more
wiley +1 more source
The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?
Journal of Periodontal Research, EarlyView.Fusobacterium nucleatum has established interactions with cancers in humans. However, contrary to a traditional view that these interactions are uniformly pro‐tumoural, recent evidence suggests a more nuanced role, where contact‐dependent and contact‐independent mechanisms may support either tumour progression or restriction depending on tumour site ...
Anjali Chander +3 more
wiley +1 more source
Advanced Science, Volume 13, Issue 43, 3 August 2026.This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo +7 more
wiley +1 more source
Heliyon, 2016 Background: Chondroitin/dermatan sulfate (CS/DS) rich in N-acetylgalactosamine 4,6-bissulfate (GalNAc(4,6SO4)) residues is present as decorin and/or biglycan in mouse liver, and GalNAc(4,6SO4) residues disappeared completely in N-acetylgalactosamine 4 ...
Hiroko Habuchi +2 more
doaj +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.ABSTRACT Background Asialoglycoprotein receptor 1 (ASGR1), a hepatocyte‐specific receptor, represents a potential therapeutic target for hypercholesterolemia. However, liver safety risks of ASGR1‐targeted therapies remain poorly characterized. This study aims to investigate the impact of ASGR1 deficency on liver fibrosis and its underlying mechanisms ...
Hui Zhu +9 more
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.Abstract Ischemic stroke remains a leading cause of death and disability worldwide, and bleeding (particularly intracranial hemorrhage) continues to limit conventional antithrombotic therapy in secondary prevention, even with direct oral anticoagulants.
Federica Ferrari, Roberto Federico Villa
wiley +1 more source
Clinical Pharmacology of Eplontersen, the First Approved GalNAc‐Conjugated Antisense Oligonucleotide
The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.Abstract Eplontersen is a GalNAc‐conjugated antisense oligonucleotide (ASO) approved for the treatment of hereditary transthyretin‐mediated amyloidosis with polyneuropathy (ATTRv‐PN). GalNAc conjugation enables targeted hepatic delivery and improved potency compared with unconjugated ASOs.
Rosie Z. Yu +4 more
wiley +1 more source
Stem Cell Research, 2019 Mucopolysaccharidosis type IVA (MPS IVA) is a rare genetic disease caused by mutations in the GALNS gene and is inherited in an autosomal recessive manner.
Rong Li +6 more
doaj +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger +18 more
wiley +1 more source