Results 61 to 70 of about 459 (131)

Potent and Sustained Lowering of Serum Uric Acid by YJH‐012‐D, a GalNAc‐Conjugated siRNA Targeting Xanthine Dehydrogenase

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
We developed a GalNAc‐conjugated siRNA targeting hepatic XDH, which effectively reduces uric acid production by silencing XDH expression, offering a promising therapeutic approach for hyperuricemia. ABSTRACT Hyperuricemia (HUA) is primarily driven by hepatic overproduction of urate, mediated by xanthine dehydrogenase (XDH).
Tingke Tang, Qiuying Li, Chenguang Zhang, Yongxing Wang, Lu Yang, Haibin Huang, Yujun He, Zhi Zheng, Dong Liang, Meng Wang, Yingyu Wu, Chengjiang Zhao, Wenhao Cui   +12 more
wiley   +1 more source

The Reality of Active Targeting in Nanomedicine: Promise Versus Performance

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
Schematic representation of a multi‐functional nanocarrier decorated with diverse ligands. Ligand type, density and spatial organisation collectively determine targeting behaviour, highlighting the complexity of active targeting beyond simple ligand–receptor interactions.
Francesco Cellesi
wiley   +1 more source

Histochemical detection of sugar residues in lizard teeth (Liolaemus gravenhorsti): a lectin-binding study

Biological Research, 2000
The structural diversity of the many oligosaccharide chains of surface glycoconjugates renders them likely candidates for modulators of cell-interactions, cellular movements, differentiation, and cellular recognition. A selection of different lectins was
MARCELA FUENZALIDA, SUSI LEMUS, JULIO ILLANES, ENRIQUE MONTIEL, OLGA ACUÑA, DAVID LEMUS   +5 more
doaj  

Preparation of radiolabeled GM2 and GA2 gangliosides.

Journal of Lipid Research, 1979
GM2 and GA2 gangliosides from the brain of a patient who died of Sandhoff's disease were purified by solvent partition, silicic acid and silica gel column chromatography, and silica gel preparative thin-layer chromatography.
A Novak, J A Lowden, Y L Gravel, L S Wolfe   +3 more
doaj   +1 more source

Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib

Drug Design, Development and Therapy, 2018
Wendu Duan, Yan Liu Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei Province 071000, People’s Republic of China Purpose: Targeted hepatocellular carcinoma therapy was carried out to improve the ...
Duan W, Liu Y
doaj  

A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide

Molecules
N-Acetylgalactosamine (GalNAc) is an efficient and multifunctional delivery tool in the development and synthesis of chemically modified oligonucleotide therapeutics (conjugates).
Artem Evgenievich Gusev, Vladimir Nikolaevich Ivanov, Nikolai Andreevich Dmitriev, Aleksandr Viktorovich Kholstov, Vladislav Aleksandrovich Vasilichin, Ilya Andreevich Kofiadi, Musa Rakhimovich Khaitov   +6 more
doaj   +1 more source

Presence of N-acetylgalactosamine/galactose residues on bronchioloalveolar cells during rat postnatal development

European Journal of Histochemistry, 2019
In mammals, the alveolarization process develops predominantly after birth. Airway cells display a complex assemblage of glycans on their surface. These glycans, particularly terminal glycan extensions, are important effective carriers of information ...
Maria de Fátima Martins, Paula Martins, Carlos Alberto Gonçalves   +2 more
doaj   +1 more source

Lectin Histochemical Study of Cell Surface Glycoconjugate in Gastric Carcinoma Using Helix Pomatia Agglutinin [PDF]

Acta Medica Iranica, 2010
"nAltered glycosylation of proteins in cancer cells is one of the main processes responsible for anaplasia, invasion and metastatic potential of neoplastic cells.
Mohammad Reza Arab, Somayeh Salari, Mehrbod Karimi, Hasan Mofidpour   +3 more
doaj   +2 more sources

Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model

Disease Models & Mechanisms, 2014
Classic galactosemia (CG) is an autosomal recessive disorder resulting from loss of galactose-1-phosphate uridyltransferase (GALT), which catalyzes conversion of galactose-1-phosphate and uridine diphosphate (UDP)-glucose to glucose-1-phosphate and UDP ...
Patricia Jumbo-Lucioni, William Parkinson, Kendal Broadie   +2 more
doaj   +1 more source

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

Molecular Therapy: Nucleic Acids, 2017
A main challenge in realizing the full potential of nucleic acid therapeutics is efficient delivery of them into targeted tissues and cells. N-acetylgalactosamine (GalNAc) is a well-defined liver-targeted moiety benefiting from its high affinity with ...
Yuanyu Huang
doaj   +1 more source