Results 1 to 10 of about 218,218 (394)

N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA

Cancer Communications, 2022
N‐acetyltransferase 10 (NAT10) is the only enzyme known to mediate the N4‐acetylcytidine (ac4C) modification of mRNA and is crucial for mRNA stability and translation efficiency.
Jingting Jiang
exaly   +2 more sources

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

Nature Biotechnology, 2015
Technologies that enable targeted manipulation of epigenetic marks could be used to precisely control cell phenotype or interrogate the relationship between the epigenome and transcriptional control.
Isaac B Hilton, Christopher M Vockley, Gregory E Crawford   +2 more
exaly   +2 more sources

Human NAT10 Is an ATP-dependent RNA Acetyltransferase Responsible for N4-Acetylcytidine Formation in 18 S Ribosomal RNA (rRNA)

Journal of Biological Chemistry, 2014
Background: Post-transcriptional modifications of rRNAs play important roles in biogenesis and function of ribosome. Results: NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation of 18 S rRNA.
Yoshikazu Tanaka, Tsutomu Suzuki
exaly   +2 more sources

Action of Dicumarol on Glucosamine-1-Phosphate Acetyltransferase of GlmU and Mycobacterium tuberculosis

Frontiers in Microbiology, 2019
Mycobacterium tuberculosis is one of most pathogenic microorganisms in the world. Previously, the bifunctional enzyme GlmU with glucosamine-1-phosphate acetyltransferase activity and N-acetylglucosamine-1-phosphate uridyltransferase activity has been ...
Xiuyan Han, Changming Chen, Qiulong Yan, Liqiu Jia, Ayaz Taj, Yufang Ma, Yufang Ma   +6 more
exaly   +3 more sources

NAA10 (N-Alpha-Acetyltransferase 10): A Multifunctional Regulator in Development, Disease, and Cancer [PDF]

Cells
NAA10 (N-alpha-acetyltransferase 10) is a pivotal enzyme in eukaryotic cells, serving as the catalytic subunit of the NatA complex, which is responsible for the N-terminal acetylation of approximately 40–50% of the human proteome.
Zeng Quan Yang, Ion John Campeanu, Ivan Lopez, Manaal Syed, Yuanyuan Jiang, Hilda Afisllari   +5 more
doaj   +2 more sources

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. [PDF]

Molecular and Cellular Biology, 1982
C Gorman, Lindsey Moffat, Bruce H. Howard   +2 more
semanticscholar   +3 more sources

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

Nature, 2013
Wenbo Li, Ola Hermanson, Daniel J Klionsky   +2 more
exaly   +2 more sources

Spotlight on Plant Bromodomain Proteins

Biology, 2023
Bromodomain-containing proteins (BRD-proteins) are the “readers” of histone lysine acetylation, translating chromatin state into gene expression.
Eirini Bardani, Paraskevi Kallemi, Martha Tselika, Konstantina Katsarou, Kriton Kalantidis   +4 more
doaj   +1 more source

Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification

Biomolecules, 2023
p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important regulator in regulating the evolution of malignant ...
Qingmei Zeng, Kun Wang, Yongxiang Zhao, Qingzhi Ma, Zhinan Chen, Wan Huang   +5 more
doaj   +1 more source

Histone acetyltransferase TaHAG1 acts as a crucial regulator to strengthen salt tolerance of hexaploid wheat

Plant Physiology, 2021
A histone acetyltransferase contributes to salt tolerance by mediating reactive oxygen species production in hexaploid wheat, which is involved in salt stress adaptability of polyploidy wheat.
Mei Zheng, Jingchen Lin, Xingbei Liu, W. Chu, Jinpeng Li, Yujiao Gao, Kexin An, Wanjun Song, Mingming Xin, Yingyin Yao, Huiru Peng, Z. Ni, Qixin Sun, Zhaorong Hu   +13 more
semanticscholar   +1 more source