Results 111 to 120 of about 218,218 (394)

CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells.

PLoS ONE, 2022
Therapeutic targeting of the estrogen receptor (ER) is a clinically validated approach for estrogen receptor positive breast cancer (ER+ BC), but sustained response is limited by acquired resistance.
Archana Bommi-Reddy, Sungmi Park-Chouinard, David N Mayhew, Esteban Terzo, Aparna Hingway, Michael J Steinbaugh, Jonathan E Wilson, Robert J Sims, Andrew R Conery   +8 more
doaj   +1 more source

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. [PDF]

, 2020
BackgroundThe trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases ...
Arkin, Michelle, Boxer, Adam L, Chen, Xu, Cuervo, Ana Maria, Gan, Li, Gestwicki, Jason E, Karydas, Anna, Li, Yaqiao, Miller, Bruce L, Mok, Sue-Ann, Rojas, Julio C, Tang, Yinyan, Tsai, Richard M, Wang, Chao   +13 more
core  

Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy. [PDF]

, 2017
Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease.
Cucchiara, Vito, Evans, Christopher P, Gao, Allen C, Mirone, Vincenzo, Rosenfeld, Michael G, Yang, Joy C   +5 more
core   +2 more sources

From Arylamine N-Acetyltransferase to Folate-Dependent Acetyl CoA Hydrolase: Impact of Folic Acid on the Activity of (HUMAN)NAT1 and Its Homologue (MOUSE)NAT2

PLoS ONE, 2014
Acetyl Coenzyme A-dependent N-, O- and N,O-acetylation of aromatic amines and hydrazines by arylamine N-acetyltransferases is well characterised. Here, we describe experiments demonstrating that human arylamine N-acetyltransferase Type 1 and its murine ...
N. Laurieri, J. Dairou, James E. Egleton, L. Stanley, A. Russell, J. Dupret, E. Sim, F. Rodrigues-Lima   +7 more
semanticscholar   +1 more source

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

Biological Function and Mechanism of NAT10 in Cancer

Cancer Innovation
N‐acetyltransferase 10 (NAT10) is a nucleolar acetyltransferase with an acetylation catalytic function and can bind various protein and RNA molecules.
Yufeng Han, Xinxin Zhang, Lei Miao, Huiran Lin, Zhenjian Zhuo, Jing He, Wen Fu   +6 more
doaj   +1 more source

Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm

Frontiers in Microbiology, 2013
Enzymatic modification is a prevalent mechanism by which bacteria defeat the action of antibiotics. Aminoglycosides are often inactivated by aminoglycoside modifying enzymes encoded by genes present in the chromosome, plasmids, and other genetic ...
María Soledad eRamirez, Nikolas eNikolaidis, Marcelo eTolmasky   +2 more
doaj   +1 more source

Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase [PDF]

, 2017
Human p300 is a polyhedric transcriptional coactivator, playing a crucial role by acetylating histones on specific lysine residues. A great deal of evidences shows that p300 is involved in several diseases as leukemia, tumors and viral infection.
Alberter, Arif, Artico, Azoulay, Balasubramanyam, Barreca, Brown, Chen, Choi, Costi, Costi, Dekker, Devipriya, Eckner, Farid, Gao, Getun, Ghizzoni, Granchi, Iyer, Iyer, Iyer, Kurdistani, Ligeret, Liu, Maddox, Mai, Maksimoska, Marcu, Noh, Osman, Ravindra, Robles, Sherman, Sherman, Sterner, Stimson, Thompson, Tintori, Toth, Tuccinardi, Valor, Vempati, Wang, Wong, Yasufumi, Zhao, Zheng, Zheng, Zhu   +49 more
core   +1 more source

Rational design and validation of a Tip60 histone acetyltransferase inhibitor

Scientific Reports, 2014
Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer.
Chunxia Gao, E. Bourke, M. Scobie, Melina Arcos Famme, Tobias Koolmeister, T. Helleday, L. Eriksson, N. Lowndes, James A. L. Brown   +8 more
semanticscholar   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source