Results 121 to 130 of about 218,218 (394)
Molecules, 2016 In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice.
Dong Wook Lim +6 more
doaj +1 more source
Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]
, 2016 AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano +3 more
core +2 more sources
Advanced Science, EarlyView.This work reports a mitochondria‐targeted nanozyme platform, MIL‐Cu1.8S‐TPP/FA, which induces potent cuproptosis via localized delivery of Cu1.8S nanodots to mitochondria. Surface‐anchoring these nanodots onto MIL‐88B metal‐organic frameworks enhances both passive and active tumor targeting.
Chenguang Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang +15 more
wiley +1 more source
Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.
, 2019 Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of interlinked activating and repressing elements. To investigate temporal regulation in this molecular oscillator, we combined mouse genetic approaches and ...
Budak, H. +4 more
core +1 more source
Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat [PDF]
, 2018 Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, there is growing evidence indicating that VEGF also acts as a neuroprotective factor, and that its administration to neurons suffering ...
Acosta, Lourdes +4 more
core +1 more source
Advanced Science, EarlyView.This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng +16 more
wiley +1 more source
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Cell type-specific regulation of choline acetyltransferase gene expression - Role of the neuron-restrictive silencer element and cholinergic-specific enhancer [PDF]
, 1996 This study demonstrates the presence of positive and negative regulatory elements within a 2336-base pair-long region of the rat choline acetyltransferase (ChAT) gene promoter that cooperate to direct cell type-specific expression in cholinergic cells. A
Anderson, David J. +3 more
core
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
Proceedings of the National Academy of Sciences of the United States of America, 2005 The ataxia telangiectasia mutant (ATM) protein kinase regulates the cell's response to DNA damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA repair.
Yingli Sun +4 more
semanticscholar +1 more source