Results 131 to 140 of about 218,218 (394)
Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules
Advanced Science, EarlyView.These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu +17 more
wiley +1 more source
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.
Journal of Biological Chemistry, 1984 Amine N-acetylation in the pineal gland is of special importance because it is the first step in the synthesis of melatonin from serotonin. In the present study the N-acetylation of arylamines and arylalkylamines by homogenates of rat and sheep pineal glands was investigated.
David C. Klein +2 more
openaire +2 more sources
Advanced Science, EarlyView.TaPPR13, a PPR protein family gene in wheat is activated by TaBZR2 to enhance drought stress tolerance and photosynthetic capacity. It achieves this by interacting with TaAOR1 and TaSIG5 to improve antioxidant defense and regulate chloroplast gene expression. Abstract The wheat (Triticum aestivum) brassinazole‐resistant 2 (TaBZR2) gene is identified as
Ze‐Hao Hou +20 more
wiley +1 more source
Advanced Science, EarlyView.L14‐8, a small molecule derived from the marketed drug ezetimibe, potently inhibits advanced prostate cancer independent of androgen receptor signaling. L14‐8 binds PLK1, triggering its ubiquitin‐mediated degradation. This activates TP53‐dependent transcription of SAT1, inducing ferroptosis and suppressing tumor growth in prostate cancer patient ...
Yu Zhang +8 more
wiley +1 more source
Functional implications of structural homologies between chloramphenicol acetyltransferase and dihydrolipoamide acetyltransferase [PDF]
FEMS Microbiology Letters, 1987 Comparisons between the amino acid sequences of the dihydrolipoamide acetyltransferase (E2p) of Escherichia coli and several chloramphenicol acetyltransferases (CATs) have revealed some well-aligned homologies which may be indicative of an underlying structural homology between the catalytic (acetyltransferase) domain of E2p and CAT.
openaire +2 more sources
Journal of Biological Chemistry, 2004 Acetylation of histones and non-histone proteins is an important post-translational modification involved in the regulation of gene expression in eukaryotes and all viral DNA that integrates into the human genome (e.g.
K. Balasubramanyam +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study provides a volumetric engineered 3D drug reservoir to combat diabetic implant infection. Cu‐doped quantum dots induce cuproptosis‐like bacterial death via metabolic collapse, while glucose oxidase triggers hunger‐triggered mitochondrial protection in host cells.
Dize Li +8 more
wiley +1 more source
Multiple Acquisitions of XopJ2 Effectors in Populations of Xanthomonas perforans
Molecular Plant-Microbe InteractionsType III effectors (T3Es) are major determinants of Xanthomonas virulence and targets for resistance breeding. XopJ2 (synonym AvrBsT) is a highly conserved YopJ-family T3E acquired by X.
Anuj Sharma +11 more
doaj +1 more source
Nucleic Acids Research, 2002 Sequence similarity and profile searching tools were used to analyze the genome sequences of Arabidopsis thaliana, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Caenorhabditis elegans and Drosophila melanogaster for genes encoding three families ...
Ritu Pandey +8 more
semanticscholar +1 more source