Results 351 to 360 of about 218,218 (394)
Some of the next articles are maybe not open access.
The phosphorylation of choline acetyltransferase
Neurochemical Research, 1989Human placental Choline Acetyltransferase (ChAT) has been shown to be phosphorylated in vitro by kinases present in rat brain. Phosphorylation occurs at a single site with the exclusive phosphoamino acid being serine. ChAT phosphorylation was shown to be calcium, and not cyclic nucleotide, dependent and was inhibited by inhibitors of calcium/calmodulin
Louis B. Hersh, Gordon Bruce
openaire +3 more sources
Histone acetyltransferase complexes
Seminars in Cell & Developmental Biology, 1999Modification of histone amino terminal tails by acetylation has long been linked to the transcriptional capacity of genes in chromatin and to various aspects of chromatin dynamics. Over the last few years a flurry of reports have described the purification and identification of a large number of histone acetyltransferases.
Shelley L. Berger, Patrick A. Grant
openaire +3 more sources
Acetyltransferases and susceptibility to chemicals
Toxicology Letters, 1992Arylamine chemicals inflict a number of toxicities including cancer. Metabolic activation (i.e., oxidation) is required in order to elicit the toxic actions. Acetylation is an important step in the metabolic activation and deactivation of arylamines. N-acetylation forms the amide derivative which is often nontoxic.
Kyle D. Bucher +7 more
openaire +3 more sources
Choline acetyltransferase in schizophrenia
American Journal of Psychiatry, 1993To test the hypothesis that schizophrenia involves altered cholinergic tone in the pons, the authors studied post-mortem brain tissue from subjects with schizophrenia.The authors used Western immunoblot to measure the concentration of choline acetyltransferase, an acetylcholine synthesizing enzyme, in the post-mortem brain tissue of 25 schizophrenic ...
C. N. Karson +3 more
openaire +3 more sources
ACETYLCHOLINE AND CHOLINE ACETYLTRANSFERASE
Neurochemistry International, 1980The thermodynamics and kinetics of the alcoholysis of thiolesters are discussed and related to choline acetyltransferase. The conformation and rotational barriers of acetylcholine are described as is the specific inability of choline to induce depolarization. Evidence is presented for the involvement of imidazole and the non-involvement of thiol groups
openaire +3 more sources
Regulation of Choline Acetyltransferase
1989Publisher Summary This chapter presents the studies related to choline acetyltransferase (ChAT) and cholinergic biology into a more comprehensive neurobiological context. The recent results of biochemical, immunological, molecular biological, arid immunocytochemical studies of ChAT and its regulation are discussed.
J E Vaughn, P M Salvaterra
openaire +3 more sources
Nomenclature for N-acetyltransferases
Pharmacogenetics, 1995A consolidated classification system is described for prokaryotic and eukaryotic N-acetyltransferases in accordance with the international rules for gene nomenclature. The root symbol (NAT) specifically identifies the genes that code for the N-acetyltransferases, and NAT* loci encoding proteins with similar function are distinguished by Arabic numerals.
Kostas P. Vatsis +12 more
openaire +3 more sources
1994
Publisher Summary Acetyltransferases play a central role in the metabolic disposition, detoxication, and bioactivation of a diverse group of drugs—carcinogens and other xenobiotics. Acetylation is a major metabolic pathway for primary aromatic amines (arylamines, ArNH) and hydrazines.
openaire +3 more sources
Publisher Summary Acetyltransferases play a central role in the metabolic disposition, detoxication, and bioactivation of a diverse group of drugs—carcinogens and other xenobiotics. Acetylation is a major metabolic pathway for primary aromatic amines (arylamines, ArNH) and hydrazines.
openaire +3 more sources
CRC Critical Reviews in Biochemistry, 1977
Acetylcholine is essential to neural function. It synthesis is catalyzed by choline acetyltransferase, the enzyme responsible for the acetylation of choline by acetyl coenzye A, a reaction favored slightly thermodymodynamically and not at all kinetically. An analytically pure enzyme still has not been obtained; however, method of purification have been
Henry G. Mautner, David Nachmansohn
openaire +2 more sources
Acetylcholine is essential to neural function. It synthesis is catalyzed by choline acetyltransferase, the enzyme responsible for the acetylation of choline by acetyl coenzye A, a reaction favored slightly thermodymodynamically and not at all kinetically. An analytically pure enzyme still has not been obtained; however, method of purification have been
Henry G. Mautner, David Nachmansohn
openaire +2 more sources
Immunohistochemistry of Choline Acetyltransferase
1979Publisher Summary This chapte discusses the problems related to immunohistochemistry of choline acetyltransferase (ChAT)-containing systems in the brain and spinal cord. The synthetic enzyme ChAT is a definitive marker for cholinergic neurons and their processes.
Patrick L. McGeer +3 more
openaire +3 more sources