Results 41 to 50 of about 218,218 (394)

A four-month gatifloxacin-containing regimen for treating tuberculosis. [PDF]

, 2014
BACKGROUND: Shortening the course of treatment for tuberculosis would be a major improvement for case management and disease control. This phase 3 trial assessed the efficacy and safety of a 4-month gatifloxacin-containing regimen for treating rifampin ...
Amukoye, Evans, Bah, Boubacar, de Jong, Bouke C, Fielding, Katherine, Gninafon, Martin, Horton, John, Kassa, Ferdinand, Lapujade, Olivier, Lienhardt, Christian, Lo, Mame B, Merle, Corinne S, Mthiyane, Thuli, N'Diaye, Alimatou, Odhiambo, Joseph, OFLOTUB/Gatifloxacin for Tuberculosis Project, Olliaro, Piero L, Perronne, Christian, Rustomjee, Roxana, Sismanidis, Charalambos, Sow, Omou Bah   +19 more
core   +1 more source

O-GlcNAcase:promiscuous hexosaminidase or key regulator of O-GlcNAc signalling? [PDF]

, 2014
O-GlcNAc signaling is regulated by an opposing pair of enzymes: O-GlcNAc transferase installs and O-GlcNAcase (OGA) removes the modification from proteins.
Banerjee, Butkinaree, Cantarel, Cecioni, Cetinba, Comtesse, Copeland, Dennis, Dong, Dorfmueller, Dorfmueller, Drougat, Forsythe, Francisco, Gao, Gong, Graham, Guinez, Hanover, Hart, Hayakawa, He, He, Heckel, Hilgers, Housley, Howerton, Hu, Itkonen, Keembiyehetty, Knapp, Laczy, Lefebvre, Lepage, Libina, Liu, Macauley, Macauley, Macauley, Macauley, Macauley, Mahuran, Martin, Minami, Müller, Nagel, Olszewski, Ostrowski, Pathak, Penton, Radermacher, Rahman, Rao, Rao, Robinson, Ruan, Ruan, Schimpl, Schimpl, Schultz, Sekine, Shen, Slawson, Speakman, Stryke, Swallow, Tews, Toleman, Toleman, Torres, Wang, Wang, Webster, Wells, Whisenhunt, Whitworth, Yang, Yu, Yuzwa, Yuzwa, Zachara, Zachara, Zhu   +82 more
core   +2 more sources

Arylamine N-Acetyltransferases in Mycobacteria [PDF]

Current Drug Metabolism, 2008
Polymorphic Human arylamine N-acetyltransferase (NAT2) inactivates the anti-tubercular drug isoniazid by acetyltransfer from acetylCoA. There are active NAT proteins encoded by homologous genes in mycobacteria including M. tuberculosis, M. bovis BCG, M. smegmatis and M. marinum. Crystallographic structures of NATs from M. smegmatis and M.
Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble MEM   +8 more
openaire   +4 more sources

The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.

Cancer Discovery, 2017
Inactivating mutations of the CREBBP acetyltransferase are highly frequent in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), the two most common germinal center (GC)-derived cancers.
Jiyuan Zhang, Sofija Vlasevska, Victoria A. Wells, Sarah E. Nataraj, A. Holmes, R. Duval, Stefanie N. Meyer, Tongwei Mo, K. Basso, Paul K. Brindle, Shafinaz Hussein, R. Dalla-Favera, L. Pasqualucci   +12 more
semanticscholar   +1 more source

Mechanisms of NAT10 as ac4C writer in diseases

Molecular Therapy: Nucleic Acids, 2023
In the early stage, N4-acetylcytidine (ac4C) was regarded as a conservative nucleoside present on tRNA and rRNA. Recently, studies have shown that ac4C also exists in human and yeast mRNA.
Lihua Xie, Xiaolin Zhong, Wenyu Cao, Jianghua Liu, Xuyu Zu, Ling Chen   +5 more
doaj  

Characterisation of two alcohol acyltransferases from kiwifruit (Actinidia spp.) reveals distinct substrate preferences. [PDF]

, 2011
Volatile esters are key compounds of kiwifruit flavour and are formed by alcohol acyltransferases that belong to the BAHD acyltransferase superfamily.
Chervin, Christian, Günther, Catrin S., Marsh, Ken B., Newcomb, Richard D., Souleyre, Edwige J.F.   +4 more
core   +1 more source

MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300

Cell Discovery, 2017
Recent studies indicate that histones are subjected to various types of acylation including acetylation, propionylation and crotonylation. CBP and p300 have been shown to catalyze multiple types of acylation but are not conserved in evolution, raising ...
X. Liu, Wei Wei, Yuting Liu, Xueli Yang, Jian Wu, Yang Zhang, Qiao Zhang, Tieliu Shi, James X. Du, Yingming Zhao, M. Lei, Jinghan Zhou, Jiwen Li, J. Wong   +13 more
semanticscholar   +1 more source

O-acetylation of Plant Cell Wall Polysaccharides

Frontiers in Plant Science, 2012
Plant cell walls are composed of structurally diverse polymers, many of which are O-acetylated. How plants O-acetylate wall polymers and what its function is remained elusive until recently, when two protein families were identified in the model plant ...
Sascha eGille, Markus ePauly
doaj   +1 more source

Gcn5 histone acetyltransferase is present in the mitoplasts [PDF]

, 2019
In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines.
De Luca, Veronica, Filetici, Patrizia, Francisci, Silvia, Leo, Manuela, Montanari, Arianna   +4 more
core   +1 more source

Structure of the Histone Acetyltransferase Hat1 [PDF]

Cell, 1998
We have solved the crystal structure of the yeast histone acetyltransferase Hat1-acetyl coenzyme A (AcCoA) complex at 2.3 A resolution. Hat1 has an elongated, curved structure, and the AcCoA molecule is bound in a cleft on the concave surface of the protein, marking the active site of the enzyme.
Rolf Sternglanz, Venki Ramakrishnan, Robert N Dutnall, Stefan T. Tafrov   +3 more
openaire   +3 more sources