Results 41 to 50 of about 203,618 (332)

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent [PDF]

, 2018
Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (
Ahmed, Shafi, Broad, John, Carroll, Rebecca, Chin-Aleong, Joanne, Darreh-Shori, Taher, Elahi, Shezan, Karami, Azadeh, Knowles, Charles H., Kung, Victor W. S., Martin, Joanne E., Palmer, Alexandra, Saffrey, M. Jill, Sanger, Gareth John, Thaha, Mohamed Adhnan   +13 more
core   +2 more sources

Lysine Acetylation in the Proteome of Renal Tubular Epithelial Cells in Diabetic Nephropathy

Frontiers in Genetics, 2021
Diabetic nephropathy is considered one of the most common microvascular complications of diabetes and the pathophysiology involves multiple factors. Progressive diabetic nephropathy is believed to be related to the structure and function of the tubular ...
Jiayi Wan, Jiayi Wan, Jiayi Wan, Jiayi Wan, Mingyang Hu, Mingyang Hu, Mingyang Hu, Mingyang Hu, Ziming Jiang, Ziming Jiang, Ziming Jiang, Ziming Jiang, Dongwei Liu, Dongwei Liu, Dongwei Liu, Dongwei Liu, Shaokang Pan, Shaokang Pan, Shaokang Pan, Shaokang Pan, Sijie Zhou, Sijie Zhou, Sijie Zhou, Sijie Zhou, Zhangsuo Liu, Zhangsuo Liu, Zhangsuo Liu, Zhangsuo Liu   +27 more
doaj   +1 more source

A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and ß-lactam resistance genes in the gut microbiota [PDF]

, 2014
peer-reviewedBackground: The potential for the human gut microbiota to serve as a reservoir for antibiotic resistance genes has been the subject of recent discussion. However, this has yet to be investigated using a rapid PCR-based approach.
Cotter, Paul D., Fitzgerald, Gerald F, Fouhy, Fiona, Ross, R Paul, STANTON, CATHERINE   +4 more
core   +1 more source

Subtelomeric Chromatin in the Fission Yeast S. pombe

Microorganisms, 2021
Telomeres play important roles in safeguarding the genome. The specialized repressive chromatin that assembles at telomeres and subtelomeric domains is key to this protective role.
Rajesh K. Yadav, Atsushi Matsuda, Brandon R. Lowe, Yasushi Hiraoka, Janet F. Partridge   +4 more
doaj   +1 more source

Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]

, 2018
Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
core   +1 more source

Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure–Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors

Biomedicines, 2021
The aminoglycoside 6′-N-acetyltransferase type Ib (AAC(6′)-Ib) is a common cause of resistance to amikacin and other aminoglycosides in Gram-negatives.
Kenneth Rocha, Jesus Magallon, Craig Reeves, Kimberly Phan, Peter Vu, Crista L. Oakley-Havens, Stella Kwan, Maria Soledad Ramirez, Travis LaVoi, Haley Donow, Prem Chapagain, Radleigh Santos, Clemencia Pinilla, Marc A. Giulianotti, Marcelo E. Tolmasky   +14 more
doaj   +1 more source

Molecular mechanisms of adaptation of the moderately halophilic bacterium Halobacillis halophilus to its environment [PDF]

, 2013
The capability of osmoadaptation is a prerequisite of organisms that live in an environment with changing salinities. Halobacillus halophilus is a moderately halophilic bacterium that grows between 0.4 and 3 M NaCl by accumulating both chloride and ...
Hänelt, Inga, Müller, Volker
core   +2 more sources

Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]

, 2016
AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano, Gatla, Himavanth, Vancura, Ales, Vancurova, Ivana   +3 more
core   +2 more sources

Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase [PDF]

, 2017
Human p300 is a polyhedric transcriptional coactivator, playing a crucial role by acetylating histones on specific lysine residues. A great deal of evidences shows that p300 is involved in several diseases as leukemia, tumors and viral infection.
Alberter, Arif, Artico, Azoulay, Balasubramanyam, Barreca, Brown, Chen, Choi, Costi, Costi, Dekker, Devipriya, Eckner, Farid, Gao, Getun, Ghizzoni, Granchi, Iyer, Iyer, Iyer, Kurdistani, Ligeret, Liu, Maddox, Mai, Maksimoska, Marcu, Noh, Osman, Ravindra, Robles, Sherman, Sherman, Sterner, Stimson, Thompson, Tintori, Toth, Tuccinardi, Valor, Vempati, Wang, Wong, Yasufumi, Zhao, Zheng, Zheng, Zhu   +49 more
core   +1 more source

Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6’)-Im

Microbial Cell, 2017
Aminoglycoside 6’-acetyltransferase-Im (AAC(6’)-Im) is the closest monofunctional homolog of the AAC(6’)-Ie acetyltransferase of the bifunctional enzyme AAC(6’)-Ie/APH(2”)-Ia.
Clyde A. Smith, Monolekha Bhattacharya, Marta Toth, Nichole K. Stewart, Sergei B. Vakulenko   +4 more
doaj   +1 more source