Results 51 to 60 of about 218,218 (394)

Beyond Histones: New Substrate Proteins of Lysine Deacetylases in Arabidopsis Nuclei

Frontiers in Plant Science, 2018
The reversible acetylation of lysine residues is catalyzed by the antagonistic action of lysine acetyltransferases and deacetylases, which can be considered as master regulators of their substrate proteins.
Magdalena Füßl, Magdalena Füßl, Ines Lassowskat, Guillaume Née, Minna M. Koskela, Annika Brünje, Priyadarshini Tilak, Jonas Giese, Dario Leister, Paula Mulo, Dirk Schwarzer, Iris Finkemeier   +11 more
doaj   +1 more source

Aminoglycoside 6′-N-acetyltransferase Type Ib [AAC(6′)-Ib]-Mediated Aminoglycoside Resistance: Phenotypic Conversion to Susceptibility by Silver Ions

Antibiotics, 2020
Clinical resistance to amikacin and other aminoglycosides is usually due to the enzymatic acetylation of the antimicrobial molecule. A ubiquitous resistance enzyme among Gram-negatives is the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib ...
Craig M. Reeves, Jesus Magallon, Kenneth Rocha, Tung Tran, Kimberly Phan, Peter Vu, Yang Yi, Crista L. Oakley-Havens, José Cedano, Verónica Jimenez, Maria S. Ramirez, Marcelo E. Tolmasky   +11 more
doaj   +1 more source

The Acetyltransferase RibT From Bacillus subtilis Affects in vivo Dynamics of the Multimeric Heavy Riboflavin Synthase Complex

Frontiers in Microbiology, 2022
Flavins are ubiquitous molecules in life as they serve as important enzyme cofactors. In the Gram-positive, soil-dwelling bacterium Bacillus subtilis, four well-characterized gene products (the enzymes RibDG, RibE, RibAB, and RibH) catalyze the ...
Daniel Andreas Orlando Rotter, Daniel Andreas Orlando Rotter, Daniel Andreas Orlando Rotter, Christoph Heger, Christoph Heger, Christoph Heger, Christian Kühm, Nina Schmidt, Nina Schmidt, Antje Schäfer, Antje Schäfer, Thomas Heimerl, Thomas Heimerl, Matthias Mack, Peter L. Graumann, Peter L. Graumann   +15 more
doaj   +1 more source

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells [PDF]

, 2016
Cancer stem cells (CSCs) play an important role in tumor initiation, progression, therapeutic failure and tumor relapse. In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl ...
Buglioni, Simonetta, Carradori, Simone, DE LUCA, Teresa, De Maria, Ruggero, Del Bufalo, Donatella, Desideri, Marianna, DI MARTILE, Marta, Eramo, Adriana, Gabellini, Chiara, Mai, Antonello, Milella, MICHELE STANISLAW, Rotili, Dante, Secci, Daniela, Sette, Giovanni, Trisciuoglio, Daniela   +14 more
core   +4 more sources

A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation

Cell Research, 2016
Transposons are generally kept silent by epigenetic mechanisms including DNA methylation. Here, we identified a pair of Harbinger transposon-derived proteins (HDPs), HDP1 and HDP2, as anti-silencing factors in Arabidopsis. hdp1 and hdp2 mutants displayed
Cheng-Guo Duan, Cheng-Guo Duan, Xingang Wang, Shaojun Xie, Li Pan, D. Miki, K. Tang, Chuan-Chih Hsu, Mingguang Lei, Yingli Zhong, Yueh-Ju Hou, Zhijuan Wang, Zhijuan Wang, Zhengjing Zhang, S. Mangrauthia, S. Mangrauthia, Hua-Wei Xu, Hua-Wei Xu, Heng Zhang, Brian P. Dilkes, W. Tao, Jian-Kang Zhu, Jian-Kang Zhu   +22 more
semanticscholar   +1 more source

Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure–Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors

Biomedicines, 2021
The aminoglycoside 6′-N-acetyltransferase type Ib (AAC(6′)-Ib) is a common cause of resistance to amikacin and other aminoglycosides in Gram-negatives.
Kenneth Rocha, Jesus Magallon, Craig Reeves, Kimberly Phan, Peter Vu, Crista L. Oakley-Havens, Stella Kwan, Maria Soledad Ramirez, Travis LaVoi, Haley Donow, Prem Chapagain, Radleigh Santos, Clemencia Pinilla, Marc A. Giulianotti, Marcelo E. Tolmasky   +14 more
doaj   +1 more source

Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease [PDF]

, 1993
Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects.
Jenner, P., Lange, Klaus W., Marsden, C. D., Wells, F. R.   +3 more
core   +1 more source

Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

Nature Communications, 2017
Diabetes and obesity are characterized by insulin resistance and chronic low-grade inflammation. An elevated plasma concentration of lipopolysaccharide (LPS) caused by increased intestinal permeability during diet-induced obesity promotes insulin ...
Jia Cao, Jinghua Peng, Hongying An, Qiyi He, T. Boronina, Shaodong Guo, M. White, P. Cole, Ling He   +8 more
semanticscholar   +1 more source

Subtelomeric Chromatin in the Fission Yeast S. pombe

Microorganisms, 2021
Telomeres play important roles in safeguarding the genome. The specialized repressive chromatin that assembles at telomeres and subtelomeric domains is key to this protective role.
Rajesh K. Yadav, Atsushi Matsuda, Brandon R. Lowe, Yasushi Hiraoka, Janet F. Partridge   +4 more
doaj   +1 more source

Molecular Basis for Histone Acetyltransferase Regulation by Binding Partners, Associated Domains, and Autoacetylation.

ACS Chemical Biology, 2016
Acetylation is a post-translational modification (PTM) that regulates chromatin dynamics and function. Dysregulation of acetylation or acetyltransferase activity has been correlated with several human diseases.
C. McCullough, R. Marmorstein
semanticscholar   +1 more source