Results 111 to 120 of about 93,058 (385)

A Genetically Encoded Homocysteine Precursor to Probe Protein Active Sites and to Addict Escherichia coli to a Noncanonical Amino Acid Directly Involved in Catalysis

Angewandte Chemie, EarlyView.
A new genetically encoded amino acid is chemically converted into homocysteine (Hcy) under mild conditions to probe and to activate protein active sites. Surprisingly, Hcy can replace cysteine or serine residues in several enzymes. Its potential for a widespread use in proteins is further underlined by rendering Escherichia coli dependent on Hcy ...
Clara Dunker, Henning D. Mootz
wiley   +2 more sources

Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates [PDF]

, 2012
The capsule polysaccharide locus (cps) is the site of the capsule biosynthesis gene cluster in encapsulated Streptococcus pneumoniae. A set of pneumococcal samples and non-pneumococcal streptococci from Denmark, the Gambia, the Netherlands, Thailand, the
Antonio, M, Bentley, SD, Bootsma, HJ, Gould, KA, Hanage, WP, Hermans, PW, Hinds, J, Lambertsen, L, O'Brien, KL, Salter, SJ, Turner, P   +10 more
core   +1 more source

A Mitochondria‐Targeted Nanozyme Platform for Multi‐Pathway Tumor Therapy via Ferroptosis and Cuproptosis Regulation

Advanced Science, EarlyView.
This work reports a mitochondria‐targeted nanozyme platform, MIL‐Cu1.8S‐TPP/FA, which induces potent cuproptosis via localized delivery of Cu1.8S nanodots to mitochondria. Surface‐anchoring these nanodots onto MIL‐88B metal‐organic frameworks enhances both passive and active tumor targeting.
Chenguang Liu, Lingxiao Guo, Yuying Cheng, Jingjie Gao, Hanling Pan, Jiayi Zhu, Danting Li, Liqing Jiao, Caiyun Fu   +8 more
wiley   +1 more source

Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening [PDF]

, 2015
Background: The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei.
Bernard A. M. Fang, FengDi Li, GangDe Zhao, HaiQing Wu, Hui Wang, KeHui Liu, LanYi Lin, Qing Xie, Shisan Bao, WeiLiang Tang, XiaoGang Xiang   +10 more
core   +3 more sources

Identification and characterization of two types of amino acid-regulated acetyltransferases in actinobacteria

Bioscience Reports, 2017
One hundred and fifty GCN5-like acetyltransferases with amino acid-binding (ACT)-GCN5-related N-acetyltransferase (GNAT) domain organization have been identified in actinobacteria. The ACT domain is fused to the GNAT domain, conferring amino acid-induced
Yu-Xing Lu, Xin-Xin Liu, Wei-Bing Liu, B. Ye   +3 more
semanticscholar   +1 more source

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

The Bacillus anthracis arylamine N-acetyltransferase ((BACAN)NAT1) that inactivates sulfamethoxazole, reveals unusual structural features compared with the other NAT isoenzymes [PDF]

, 2011
Arylamine N-acetyltransferases (NATs) are xenobiotic-metabolizing enzymes that biotransform arylamine drugs. The Bacillus anthracis (BACAN)NAT1 enzyme affords increased resistance to the antibiotic sulfamethoxazole through its acetylation.
Dairou, Julien, Dupret, Jean-Marie, Kubiak, Xavier, Pluvinage, Benjamin, Rodrigues-Lima, Fernando, Sierra-Gallay, Inés Li de la, Xu, Ximing   +6 more
core   +1 more source

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults

Advanced Science, EarlyView.
This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng, Yuening Cao, Senmiao Ren, Chaozheng Zhang, Jianan Liu, Ke Liu, Yan Wang, Hongyu Chen, Fengjiao Zhou, Xiuli Yang, Xian Ge, Tingting Zhang, Tianbao Wang, Yao He, Defang Li, Chuantao Zhang, Jun Lu   +16 more
wiley   +1 more source

Review: Acetylation mechanisms and targeted therapies in cardiac fibrosis

Pharmacological Research, 2023
Cardiac fibrosis is a common pathophysiological remodeling process that occurs in a variety of cardiovascular diseases and greatly influences heart structure and function, progressively leading to the development of heart failure.
Weikang Liu, Qiuhuan Yuan, Shengchuan Cao, Guoying Wang, Xiangguo Liu, Yanan Xia, Yuan Bian, Feng Xu, Yuguo Chen   +8 more
doaj  

Assembly of specialised chromatin at Fission Yeast Centromeres [PDF]

, 2015
Despite the conserved essential function of centromeres, centromeric DNA is not conserved between species. There is strong evidence indicating that centromeres are epigenetically regulated. Although centromeres normally assemble on preferred sequences,
Pidoux, Alison L.
core