Results 121 to 130 of about 93,058 (385)

Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms [PDF]

, 2016
Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs).
A Ametzazurra, A Ben-Bassat, A Hershko, A Marintchev, A Murthi, A Pimenta-Marques, A Shemorry, A Staes, A Yoshikawa, AF Rope, AI Saeed, AL Pang, AO Helbig, B Polevoda, B Polevoda, B Polevoda, B Polevoda, B Polevoda, B Zybailov, BC Williams, CS Hwang, D Lang, D Zattas, DC Scott, EC Park, EV Koonin, G Liszczak, G Liszczak, G Liszczak, G Talavera, G Zhang, GM Forte, H Aksnes, HS Yoon, HY Zhu, I Dikiy, I Hofmann, J Sanchez, JD Jones, JL Brown, JM Singer, JP Casey, JR Mullen, K Hole, KK Starheim, KK Starheim, KK Starheim, LG Guilgur, LM Myklebust, M Gautschi, MA Larkin, MD Katinka, ML Angus-Hill, N Arnaudo, OK Song, P Van Damme, P Van Damme, P Van Damme, P Van Damme, P Van Damme, P Van Damme, R Behnia, R Evjenth, R Shemesh, RD Finn, RD Silva, RP Moerschell, S Capella-Gutierrez, S Goetze, S Hoshiyasu, S Tanaka, SF Altschul, SR Setty, T Arnesen, T Arnesen, T Arnesen, T Arnesen, T Arnesen, T Arnesen, T Esmailpour, T van Welsem, TB Chou, TV Dinh, TV Kalvik, TY James, WV Bienvenut, WV Bienvenut, Y Wang, YY Chang   +88 more
core   +2 more sources

Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules

Advanced Science, EarlyView.
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu, Xinran Liu, Mei Xue, Yushuo Xiao, Yuchen Chen, Rong Qiu, Di Wu, Yihao Zhou, Jiao Wang, Yan Yuan, Linwei Yu, Tianyi Shi, Yangkai Li, Hua Su, Hong Chen, Yong Liu, Kun Huang, Ling Zheng   +17 more
wiley   +1 more source

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.

Journal of Biological Chemistry, 1984
Amine N-acetylation in the pineal gland is of special importance because it is the first step in the synthesis of melatonin from serotonin. In the present study the N-acetylation of arylamines and arylalkylamines by homogenates of rat and sheep pineal glands was investigated.
David C. Klein, Pierre Voisin, M. A. A. Namboodiri   +2 more
openaire   +2 more sources

TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
ID1 is regulated by E3 ligase TRIM21, which adds non‐degradative K11‐linked ubiquitin at Lys91, disrupting ID1‐TCF12 binding and freeing TCF12 to upregulate copper transporter SLC31A1. Enhanced SLC31A1 elevates intracellular copper, triggers cuproptosis, and inhibits ESCC growth.
Lei Li, Yuqing Wang, Ruoxi Tian, Tianshuo Yang, Yaxin Liu, Baoen Shan, Lianmei Zhao   +6 more
wiley   +1 more source

Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]

, 2015
In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia, Saccone, Valentina, Sandona', Martina   +2 more
core   +4 more sources

TaPPR13, a Pentatricopeptide Repeat Protein Gene Activated by TaBZR2, Confers Drought Stress Tolerance by Enhancing the Antioxidant Defense System and Promoting Retrograde Signaling in Wheat (Triticum aestivum)

Advanced Science, EarlyView.
TaPPR13, a PPR protein family gene in wheat is activated by TaBZR2 to enhance drought stress tolerance and photosynthetic capacity. It achieves this by interacting with TaAOR1 and TaSIG5 to improve antioxidant defense and regulate chloroplast gene expression. Abstract The wheat (Triticum aestivum) brassinazole‐resistant 2 (TaBZR2) gene is identified as
Ze‐Hao Hou, Wei‐Jun Zheng, Lei Zheng, Jing‐Yue Wang, Shuang‐Xi Zhang, Ji‐Tong Wei, Shu‐Hui Yang, Yuan‐Chen Jiao, Wen‐Jing Cheng, Tai‐Fei Yu, Xiao‐Fei Ma, Jing‐Na Ru, Yong‐Wei Liu, Xin‐You Cao, Jun Chen, Yong‐Bin Zhou, Ming Chen, Li‐Hui Li, You‐Zhi Ma, Xiao‐Jun Nie, Zhao‐Shi Xu   +20 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity

Research
Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes.
Sanjeeb Shrestha, Yu-Bin Lee, Hoyul Lee, Yeon-Kyung Choi, Bo-Yoon Park, Mi-Jin Kim, Young-Jin Youn, Sun-Hwa Kim, Soo-Jung Jung, Dong-Keun Song, Hee Kyung Jin, Jae-Sung Bae, In-Kyu Lee, Jae-Han Jeon, Chang-Won Hong   +14 more
doaj   +1 more source

Functional implications of structural homologies between chloramphenicol acetyltransferase and dihydrolipoamide acetyltransferase [PDF]

FEMS Microbiology Letters, 1987
Comparisons between the amino acid sequences of the dihydrolipoamide acetyltransferase (E2p) of Escherichia coli and several chloramphenicol acetyltransferases (CATs) have revealed some well-aligned homologies which may be indicative of an underlying structural homology between the catalytic (acetyltransferase) domain of E2p and CAT.
openaire   +2 more sources