Results 141 to 150 of about 95,792 (372)
PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature
Clinical Pharmacology &Therapeutics, EarlyView.The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou +14 more
wiley +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk +4 more
wiley +1 more source
GCN5 potentiates Hepatocellular Carcinoma by Promoting SRC3 gene expression [PDF]
, 2015 摘要 组蛋白乙酰化在转录调节过程中起着重要的作用，它可以使染色体处于一种活化的状态。在细胞中，维持组蛋白的乙酰化和去乙酰化之间的平衡是通过组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（HDACs）这二者间的平衡实现的。如果这二者间的平衡被打破了，那么基因的乙酰化水平就改变了，从而可能诱发癌症。虽然HDACs抑制剂可以有效的预防和治疗癌症，但是一些抑制剂会激活一些非靶基因从而使人出现抗药性。为了确保乙酰化和去乙酰化之间的完全平衡以及掌握在癌症中HATs在组蛋白乙酰化过程中特定的功能 ...
SIDRA MAJAZ
core
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300.
Cell Chemical Biology, 2020 Raghu Vannam +11 more
semanticscholar +1 more source
Epilepsia Open, EarlyView.Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira +5 more
wiley +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
Biochemistry and Biophysics ReportsThe cytosolic enzymes N-Acetyl Transferases 1 and 2 (NATs) transfer an acetyl group from acetyl-CoA to a xenobiotic substrate. NATs are regulated at the genetic and epigenetic levels by deacetylase enzymes such as sirtuins.
Víctor Alejandro Paz-Rodríguez +10 more
doaj +1 more source
Nature Communications, 2019 E2F1, which localises to DNA double-strand breaks (DSBs) to promote repair, is acetylated in response to DNA damage but the role this plays in DNA repair is unknown. Here the authors show that E2F1 acetylation creates a binding motif for the bromodomains
Swarnalatha Manickavinayaham +8 more
doaj +1 more source
An extracellular factor regulating expression of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii [PDF]
, 1997 Philip N. Rather +2 more
openalex +1 more source
Clock gene dysregulation in epilepsy: A systematic review
Epilepsia Open, EarlyView.Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos +3 more
wiley +1 more source