Results 161 to 170 of about 95,792 (372)

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Human N-acetyltransferase 1 *10 and *11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity

, 2011
Daqing Wang, Michael F. Para, Susan L. Koletar, Wolfgang Sadée   +3 more
openalex   +2 more sources

Polyamine regulation of heat-shock-induced spermidine N1-acetyltransferase activity [PDF]

, 1990
David J. Fuller, Stephen W. Carper, Laurel P. Clay, J R Chen, Eugene W. Gerner   +4 more
openalex   +1 more source

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.

Molecules and Cells, 2019
Henriette Aksnes, Rasmus Ree, T. Arnesen
semanticscholar   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression

, 2016
Dennis Warner, Scott C. Smith, Irina Smolenkova, Marina Pisano, Robert M. Greene   +4 more
openalex   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Targeting EP300 in diffuse large b-cell lymphoma: efficacy of A485 and synergistic effects with XPO1 inhibition

BMC Cancer
Background Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematopoietic malignancy, necessitating the exploration of innovative therapeutic approaches. Targeting epigenetic mechanisms has emerged as a promising avenue for cancer treatment.
Yanan Jiang, Donghui Xing, Xiang He, Wenqi Wu, Hong Xu, Huimeng Sun, Yixin Zhai, Kaiping Luo, Zhigang Zhao   +8 more
doaj   +1 more source

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Nature, 2018
J. Baell, D. Leaver, S. Hermans, G. Kelly, Margs S. Brennan, Natalie L. Downer, Nghi Nguyen, Johannes Wichmann, Helen M. McRae, Yuqing Yang, Ben Cleary, H. R. Lagiakos, S. Mieruszynski, Guido Pacini, H. Vanyai, M. Bergamasco, Rose E. May, B. Davey, Kimberly J Morgan, Andrew J. Sealey, Beinan Wang, N. Zamudio, Stephen A. Wilcox, A. Garnham, Bilal N. Sheikh, Brandon J. Aubrey, Karen Doggett, M. Chung, Melanie de Silva, J. Bentley, P. Pilling, M. Hattarki, O. Dolezal, M. Dennis, Hendrik Falk, B. Ren, S. Charman, K. White, J. Rautela, A. Newbold, E. Hawkins, R. Johnstone, N. Huntington, T. Peat, J. Heath, A. Strasser, M. Parker, G. Smyth, I. Street, B. Monahan, A. Voss, T. Thomas   +51 more
semanticscholar   +1 more source