Multiple N-acetyltransferases and drug metabolism. Tissue distribution, characterization and significance of mammalian N-acetyltransferase [PDF]
, 1973 D. J. Hearse, Wendell W. Weber
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Targeted degradation of the enhancer lysine acetyltransferases CBP and p300.
Cell Chemical Biology, 2020 Raghu Vannam +11 more
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The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability
Cytoskeleton, EarlyView.ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou +6 more
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Regional distribution of choline acetyltransferase in the human brain: changes in Huntington's chorea. [PDF]
, 1975 Sten‐Magnus Aquilonius +2 more
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ChemMedChem, EarlyView.Two PROTAC‐based degraders targeting the cancer‐associated transcriptional co‐activators CBP/p300 weredeveloped. These degraders, combining the CBP/p300 inhibitor C646 with the CRBN ligand thalidomide, reduced CBP/p300 levels in lymphoma cells at low‐micromolar concentration.
Francesco Fiorentino +9 more
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Multiple forms of choline acetyltransferase in several species demonstrated by isoelectric focusing [PDF]
, 1972 D. Malthe‐Sørenssen, Frode Fonnum
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The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Cell, 1996 V. Ogryzko +4 more
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Clinical Pharmacology in Drug Development, EarlyView.Abstract A modified controlled‐release sodium valproate formulation (VAL001, test) was compared with an approved enteric‐coated tablet formulation (Absenor, reference). Pharmacokinetics and safety/tolerability were evaluated in healthy subjects to bridge with positive efficacy results from an early‐phase patient trial of valproate in combination with ...
Nikhil Ahuja +8 more
wiley +1 more source
Enzymatic Modification of Aminoglycoside Antibiotics: 3- N -Acetyltransferase with Broad Specificity that Determines Resistance to the Novel Aminoglycoside Apramycin [PDF]
, 1978 Julian Davies, Sean O'Connor
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Elp1 function in placode‐derived neurons is critical for proper trigeminal ganglion development
Developmental Dynamics, EarlyView.Abstract Background The trigeminal nerve is the largest cranial nerve and functions in somatosensation. Cell bodies of this nerve are positioned in the trigeminal ganglion, which arises from the coalescence of neural crest and placode cells. While this dual cellular origin has been known for decades, the molecular mechanisms controlling trigeminal ...
Margaret A. Hines, Lisa A. Taneyhill
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