Results 171 to 180 of about 93,058 (385)

NAT10 regulates tumor progression and immune microenvironment in pancreatic ductal adenocarcinoma via the N4‐acetylated LAMB3‐mediated FAK/ERK pathway

open access: yesCancer Communications, EarlyView.
Abstract Background N‐acetyltransferase 10 (NAT10) was reported to be associated with the immune microenvironment in several cancers. However, it is not known in pancreatic ductal adenocarcinoma (PDAC). This study aimed to elucidate the roles and mechanisms of NAT10 in tumor malignancy and the tumor microenvironment (TME) in PDAC.
Enhong Chen   +11 more
wiley   +1 more source

Antibacterial Essential Oils as Adjuvants to Inhibit Antibiotic Resistance in Multidrug‐resistant Bacteria

open access: yesChemistry &Biodiversity, EarlyView.
Combining bacterially inactivated antibiotics with antibacterial essential oils (EOs) is an alternative combinatorial therapy against antibiotic‐resistant bacteria, as EOs can also modulate resistance. Apart from the rehabilitation of the antibiotic, this combination is probably more difficult to overcome evolutionarily due to the antibacterial mixture
Rafael Torres‐Martínez   +5 more
wiley   +1 more source

5‐thiohistidine N‐acetyltransferase from Proteiniphilum saccharofermentans

open access: yesChemBioChem, Accepted Article.
Ovothiol A is a 5‐thiohistidine derivative biosynthesized by a broad range of prokaryotic and eukaryotic organisms. Its redox‐active mercaptoimidazole side chain is believed to protect cells from oxidative stress. The three enzymes that produce ovothiol A from histidine, cysteine, and S‐adenosyl methionine have been identified and characterized.
Cangsong Liao   +3 more
wiley   +1 more source

A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations

open access: yesChemBioChem, EarlyView.
Site‐specifically phosphorylated isoforms of the tumor suppressor p53 – encompassing all seven known phosphorylation sites within the TAD1 domain –are created upon optimization of semisynthesis protocols. This “designer" p53 library enabled validation of phosphorylation‐specific p53 antibodies and revealed epitope masking by phosphorylation in commonly
Mateusz Hess   +6 more
wiley   +1 more source

In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins

open access: yesChemBioChem, Accepted Article.
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska   +2 more
wiley   +1 more source

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