NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury
In diabetic kidney disease (DKD), the acetyltransferase NAA10 mediates the acetylation of CREBRF, promoting its recognition and binding by the E3 ubiquitin ligase BTRC, thereby enhancing the ubiquitination level of CREBRF and accelerating its degradation.
Sitian Fang +3 more
wiley +1 more source
Targeting NF-κB signaling for HIV latency reversal: Mechanisms, challenges, and therapeutic perspectives. [PDF]
Shirazi MMA, Sadat SM.
europepmc +1 more source
The transcriptional adapter ADA2 interacts with the histone acetyltransferase GCN5 to regulate starch and storage protein content in wheat grains through histone acetylation. ADA2 undergoes phase separation and is modulated by GCN5, affecting histone acetyltransferase activity and gene transcription.
Xiaobang Zhang +15 more
wiley +1 more source
Molecular functional mechanisms of two alcohol acetyltransferases in <i>Lavandula x intermedia</i> (lavandin). [PDF]
Liu D +8 more
europepmc +1 more source
Genomic variation drives plant flavor diversification
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu +5 more
wiley +1 more source
Polyamine metabolism as a regulator of cellular and organismal aging. [PDF]
Uemura T, Takayama J, Oguro A, Terui Y.
europepmc +1 more source
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer +4 more
wiley +1 more source
Histone and N-terminal acetyltransferases play important roles in female reproduction and embryogenesis of the red flour beetle Tribolium castaneum. [PDF]
Sengodan K, Palli SR.
europepmc +1 more source
The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets
We introduce the MacBrain Resource Center (MBRC) Collections of rhesus macaque embryonic brain tissue. Here, we illustrate histo‐ and immunohistology from our dynamically growing Collection 6, which currently contains >10,000 zoomable and downloadable images from n = 14 male and female embryos from early to late in gestation.
Valeria Mendoza‐Silva +11 more
wiley +1 more source

