Results 261 to 270 of about 38,885 (308)
Some of the next articles are maybe not open access.
Annual Review of Biochemistry, 2001
▪ Abstract  Transcriptional regulation in eukaryotes occurs within a chromatin setting and is strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well-known covalent modifications of histones, the reversible acetylation of internal lysine residues in histone amino-terminal domains has long been positively linked to ...
John M Denu
exaly +3 more sources
▪ Abstract  Transcriptional regulation in eukaryotes occurs within a chromatin setting and is strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well-known covalent modifications of histones, the reversible acetylation of internal lysine residues in histone amino-terminal domains has long been positively linked to ...
John M Denu
exaly +3 more sources
Choline acetyltransferase and carnitine acetyltransferase in the placenta of the mouse
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1977Abstract 1. The major 1-14C-acetyl labelled metabolite as identified by high voltage electrophoresis and thin layer chromatography was 1-14C-acetylcarnitine when crude or dialyzed mouse placenta homogenates were incubated in the absence or presence of exogenous 1-carnitine respectively and with 1-14C-acetylcoenzyme A. 2.
Susan K. McCarthy, Frank Welsch
openaire +3 more sources
Expert Opinion on Drug Metabolism & Toxicology, 2007
Arylamine N-acetyltransferases (NATs), known as drug- and carcinogen-metabolising enzymes, have had historic roles in cellular metabolism, carcinogenesis and pharmacogenetics, including epidemiological studies of disease susceptibility. NAT research in the past 5 years builds on that history and additionally paves the way for establishing the following
Sim, Edith +2 more
openaire +5 more sources
Arylamine N-acetyltransferases (NATs), known as drug- and carcinogen-metabolising enzymes, have had historic roles in cellular metabolism, carcinogenesis and pharmacogenetics, including epidemiological studies of disease susceptibility. NAT research in the past 5 years builds on that history and additionally paves the way for establishing the following
Sim, Edith +2 more
openaire +5 more sources
Human acetyltransferase polymorphisms
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1997Conjugation of primary amino and hydroxylamino groups with acetate, catalyzed by acetyl CoA-dependent arylamine acetyltransferase (NAT) enzymes, may play an important role in the intricate series of metabolic pathways that produce or prevent toxicity following exposure to homo- and heterocyclic arylamine and hydrazine xenobiotics.
Hillary J Chen +7 more
openaire +3 more sources
A snapshot of carnitine acetyltransferase
Trends in Biochemical Sciences, 2003Carnitine acetyltransferase (CrAT) is part of the carnitine system that protects the acylation state of the pools of acetyl-coenzyme A, a key metabolic intermediate, by transferring excess acetate and other short-chain acyl groups to and from carnitine. The homology of CrAT with other carnitine acyltransferases, such as carnitine palmitoyltransferase I
Rona R. Ramsay, James H. Naismith
openaire +3 more sources
The phosphorylation of choline acetyltransferase
Neurochemical Research, 1989Human placental Choline Acetyltransferase (ChAT) has been shown to be phosphorylated in vitro by kinases present in rat brain. Phosphorylation occurs at a single site with the exclusive phosphoamino acid being serine. ChAT phosphorylation was shown to be calcium, and not cyclic nucleotide, dependent and was inhibited by inhibitors of calcium/calmodulin
Louis B. Hersh, Gordon Bruce
openaire +3 more sources
Histone acetyltransferase complexes
Seminars in Cell & Developmental Biology, 1999Modification of histone amino terminal tails by acetylation has long been linked to the transcriptional capacity of genes in chromatin and to various aspects of chromatin dynamics. Over the last few years a flurry of reports have described the purification and identification of a large number of histone acetyltransferases.
Shelley L. Berger, Patrick A. Grant
openaire +3 more sources
Acetyltransferases and susceptibility to chemicals
Toxicology Letters, 1992Arylamine chemicals inflict a number of toxicities including cancer. Metabolic activation (i.e., oxidation) is required in order to elicit the toxic actions. Acetylation is an important step in the metabolic activation and deactivation of arylamines. N-acetylation forms the amide derivative which is often nontoxic.
Kyle D. Bucher +7 more
openaire +3 more sources
Choline acetyltransferase in schizophrenia
American Journal of Psychiatry, 1993To test the hypothesis that schizophrenia involves altered cholinergic tone in the pons, the authors studied post-mortem brain tissue from subjects with schizophrenia.The authors used Western immunoblot to measure the concentration of choline acetyltransferase, an acetylcholine synthesizing enzyme, in the post-mortem brain tissue of 25 schizophrenic ...
C. N. Karson +3 more
openaire +3 more sources
ACETYLCHOLINE AND CHOLINE ACETYLTRANSFERASE
Neurochemistry International, 1980The thermodynamics and kinetics of the alcoholysis of thiolesters are discussed and related to choline acetyltransferase. The conformation and rotational barriers of acetylcholine are described as is the specific inability of choline to induce depolarization. Evidence is presented for the involvement of imidazole and the non-involvement of thiol groups
openaire +3 more sources