Results 241 to 250 of about 33,126 (285)

ACETYLCHOLINE AND CHOLINE ACETYLTRANSFERASE

Neurochemistry International, 1980
The thermodynamics and kinetics of the alcoholysis of thiolesters are discussed and related to choline acetyltransferase. The conformation and rotational barriers of acetylcholine are described as is the specific inability of choline to induce depolarization. Evidence is presented for the involvement of imidazole and the non-involvement of thiol groups
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Human acetyltransferase polymorphisms

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997
Conjugation of primary amino and hydroxylamino groups with acetate, catalyzed by acetyl CoA-dependent arylamine acetyltransferase (NAT) enzymes, may play an important role in the intricate series of metabolic pathways that produce or prevent toxicity following exposure to homo- and heterocyclic arylamine and hydrazine xenobiotics.
D M, Grant, N C, Hughes, S A, Janezic, G H, Goodfellow, H J, Chen, A, Gaedigk, V L, Yu, R, Grewal   +7 more
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Histone acetyltransferase complexes

Seminars in Cell & Developmental Biology, 1999
Modification of histone amino terminal tails by acetylation has long been linked to the transcriptional capacity of genes in chromatin and to various aspects of chromatin dynamics. Over the last few years a flurry of reports have described the purification and identification of a large number of histone acetyltransferases.
P A, Grant, S L, Berger
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Regulation of Choline Acetyltransferase

1989
Publisher Summary This chapter presents the studies related to choline acetyltransferase (ChAT) and cholinergic biology into a more comprehensive neurobiological context. The recent results of biochemical, immunological, molecular biological, arid immunocytochemical studies of ChAT and its regulation are discussed.
P M, Salvaterra, J E, Vaughn
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N-Acetyltransferases, O-Acetyltransferases, and N, O-Acetyltransferases: Enzymology and Bioactivation

1994
Publisher Summary Acetyltransferases play a central role in the metabolic disposition, detoxication, and bioactivation of a diverse group of drugs—carcinogens and other xenobiotics. Acetylation is a major metabolic pathway for primary aromatic amines (arylamines, ArNH) and hydrazines.
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Nomenclature for N-acetyltransferases

Pharmacogenetics, 1995
A consolidated classification system is described for prokaryotic and eukaryotic N-acetyltransferases in accordance with the international rules for gene nomenclature. The root symbol (NAT) specifically identifies the genes that code for the N-acetyltransferases, and NAT* loci encoding proteins with similar function are distinguished by Arabic numerals.
Kostas P. Vatsis, Wendell W. Weber, Douglas A. Bell, Jean-Marie Dupret, David A. Price Evans, Denis M. Grant, David W. Hein, Henry J. Lin, Urs A. Meyer, Mary V. Relling, Edith Sim, Tomokazu Suzuki, Yasushi Yamazoe   +12 more
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Choline acetyltransferase in schizophrenia

American Journal of Psychiatry, 1993
To test the hypothesis that schizophrenia involves altered cholinergic tone in the pons, the authors studied post-mortem brain tissue from subjects with schizophrenia.The authors used Western immunoblot to measure the concentration of choline acetyltransferase, an acetylcholine synthesizing enzyme, in the post-mortem brain tissue of 25 schizophrenic ...
C N, Karson, M F, Casanova, J E, Kleinman, W S, Griffin   +3 more
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Chloramphenicol Acetyltransferase Assay

Cold Spring Harbor Protocols, 2010
INTRODUCTIONWhen a transient or stable transfection assay is developed for a promoter, a primary objective is to quantify promoter strength. Because transfection efficiency in such assays can be low, promoters are commonly fused to heterologous reporter genes that encode enzymes that can be quantified using highly sensitive assays. The reporter protein’
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In vitro acetyltransferase activity assays for N-terminal acetyltransferases

N-terminal acetyltransferases (NATs) mediate co- and post-translational N-terminal protein acetylation to mediate essential protein functions, and their altered activities are linked to several diseases. Because of this connection of NATs to normal and abnormal cellular function, it is important to have assays available to evaluate NAT activity in ...
Taining, Li, David C, Schultz, Ronen, Marmorstein   +2 more
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Immunohistochemistry of Choline Acetyltransferase

1979
Publisher Summary This chapte discusses the problems related to immunohistochemistry of choline acetyltransferase (ChAT)-containing systems in the brain and spinal cord. The synthetic enzyme ChAT is a definitive marker for cholinergic neurons and their processes.
E G, McGeer, P L, McGeer, T, Hattori, V K, Singh   +3 more
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