Results 231 to 240 of about 35,074 (278)

Regulation of Choline Acetyltransferase

1989
Publisher Summary This chapter presents the studies related to choline acetyltransferase (ChAT) and cholinergic biology into a more comprehensive neurobiological context. The recent results of biochemical, immunological, molecular biological, arid immunocytochemical studies of ChAT and its regulation are discussed.
P M, Salvaterra, J E, Vaughn
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Nomenclature for N-acetyltransferases

Pharmacogenetics, 1995
A consolidated classification system is described for prokaryotic and eukaryotic N-acetyltransferases in accordance with the international rules for gene nomenclature. The root symbol (NAT) specifically identifies the genes that code for the N-acetyltransferases, and NAT* loci encoding proteins with similar function are distinguished by Arabic numerals.
Kostas P. Vatsis, Wendell W. Weber, Douglas A. Bell, Jean-Marie Dupret, David A. Price Evans, Denis M. Grant, David W. Hein, Henry J. Lin, Urs A. Meyer, Mary V. Relling, Edith Sim, Tomokazu Suzuki, Yasushi Yamazoe   +12 more
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Acetyltransferases and susceptibility to chemicals

Toxicology Letters, 1992
Arylamine chemicals inflict a number of toxicities including cancer. Metabolic activation (i.e., oxidation) is required in order to elicit the toxic actions. Acetylation is an important step in the metabolic activation and deactivation of arylamines. N-acetylation forms the amide derivative which is often nontoxic.
D W, Hein, T D, Rustan, M A, Doll, K D, Bucher, R J, Ferguson, Y, Feng, E J, Furman, K, Gray   +7 more
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The phosphorylation of choline acetyltransferase

Neurochemical Research, 1989
Human placental Choline Acetyltransferase (ChAT) has been shown to be phosphorylated in vitro by kinases present in rat brain. Phosphorylation occurs at a single site with the exclusive phosphoamino acid being serine. ChAT phosphorylation was shown to be calcium, and not cyclic nucleotide, dependent and was inhibited by inhibitors of calcium/calmodulin
G, Bruce, L B, Hersh
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Choline acetyltransferase in schizophrenia

American Journal of Psychiatry, 1993
To test the hypothesis that schizophrenia involves altered cholinergic tone in the pons, the authors studied post-mortem brain tissue from subjects with schizophrenia.The authors used Western immunoblot to measure the concentration of choline acetyltransferase, an acetylcholine synthesizing enzyme, in the post-mortem brain tissue of 25 schizophrenic ...
C N, Karson, M F, Casanova, J E, Kleinman, W S, Griffin   +3 more
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Chloramphenicol Acetyltransferase Assay

Cold Spring Harbor Protocols, 2010
INTRODUCTIONWhen a transient or stable transfection assay is developed for a promoter, a primary objective is to quantify promoter strength. Because transfection efficiency in such assays can be low, promoters are commonly fused to heterologous reporter genes that encode enzymes that can be quantified using highly sensitive assays. The reporter protein’
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Regulation of Arylamine N-Acetyltransferases

Current Drug Metabolism, 2008
Acetylation catalysed by the arylamine N-acetyltransferases (NATs; 2.3.1.5) is a major biotransformation pathway for arylamine and hydrazine drugs, as well as many carcinogens that we are exposed to on a daily basis. These compounds can either be detoxified by NATs or bioactivated to metabolites that have the potential to cause toxicity such as cancer.
Butcher, Neville J., Tiang, Jacky, Minchin, Rodney F.   +2 more
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In vitro acetyltransferase activity assays for N-terminal acetyltransferases

N-terminal acetyltransferases (NATs) mediate co- and post-translational N-terminal protein acetylation to mediate essential protein functions, and their altered activities are linked to several diseases. Because of this connection of NATs to normal and abnormal cellular function, it is important to have assays available to evaluate NAT activity in ...
Taining, Li, David C, Schultz, Ronen, Marmorstein   +2 more
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Immunohistochemistry of Choline Acetyltransferase

1979
Publisher Summary This chapte discusses the problems related to immunohistochemistry of choline acetyltransferase (ChAT)-containing systems in the brain and spinal cord. The synthetic enzyme ChAT is a definitive marker for cholinergic neurons and their processes.
E G, McGeer, P L, McGeer, T, Hattori, V K, Singh   +3 more
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Chloramphenicol Acetyltransferases

Annual Review of Biophysics and Biophysical Chemistry, 1989
W V, Shaw, A G, Leslie
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