Results 61 to 70 of about 91,412 (386)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Modeling Suggests Combined-Drug Treatments for Disorders Impairing Synaptic Plasticity via Shared Signaling Pathways [PDF]

arXiv, 2020
Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning and memory. Can pharmacological therapies be suggested to improve learning and memory in these disorders?
arxiv  

Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism

Communications Biology, 2021
Rigby et al. use transgenic mice that are deficient in the endoplasmic reticulum acetyltransferases Atase1 or Atase2 to demonstrate the differential role of these enzymes in the regulation of reticulophagy and macroautophagy.
Michael J. Rigby, Alexis J. Lawton, Gulpreet Kaur, Varuna C. Banduseela, William E. Kamm, Aparna Lakkaraju, John M. Denu, Luigi Puglielli   +7 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Plant responses to abiotic stress: the chromatin context of transcriptional regulation [PDF]

, 2017
The ability of plants to cope with abiotic environmental stresses such as drought, salinity, heat, cold or flooding relies on flexible mechanisms for re-programming gene expression. Over recent years it has become apparent that transcriptional regulation
Amtmann, Anna, Asensi-Fabado, Maria Amparo, Perrella, Giorgio   +2 more
core   +1 more source

Polymorphism of Human Acetyltransferases

Environmental Health Perspectives, 1994
Acetylation by arylamine N-acetyltransferases (NATs) is a major route in the metabolism of numerous drugs and carcinogens. Recent studies suggest that the same enzymes also catalyze N,O-transacetylation and O-acetylation. A genetic polymorphism of clinical relevance divides the human population into slow and rapid acetylators of arylamines.
openaire   +3 more sources

O-acetylated Gangliosides as Targets for Cancer Immunotherapy

Cells, 2020
O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.
Sumeyye Cavdarli, Philippe Delannoy, Sophie Groux-Degroote   +2 more
doaj   +1 more source

Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5

Journal of Biological Chemistry, 2018
Histone acetylation plays crucial roles in transcriptional regulation and chromatin organization. Viral RNA of the influenza virus interacts with its nucleoprotein (NP), whose function corresponds to that of eukaryotic histones.
D. Hatakeyama, M. Shoji, S. Yamayoshi, Rina Yoh, N. Ohmi, S. Takenaka, A. Saitoh, Yumie Arakaki, A. Masuda, Tsugunori Komatsu, Rina Nagano, Masahiro Nakano, T. Noda, Y. Kawaoka, T. Kuzuhara   +14 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Identification of a New Family of Enzymes with Potential \u3cem\u3eO\u3c/em\u3e-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria [PDF]

, 2005
Background: The metabolism of the rigid bacterial cell wall heteropolymer peptidoglycan is a dynamic process requiring continuous biosynthesis and maintenance involving the coordination of both lytic and synthetic enzymes.
Clarke, Anthony J., Pfeffer, John M., Weadge, Joel T.   +2 more
core   +1 more source