Results 31 to 40 of about 124,541 (336)

N-acetylcholinesterase-induced apoptosis in Alzheimer's disease. [PDF]

PLoS ONE, 2008
BackgroundAlzheimer's disease (AD) involves loss of cholinergic neurons and Tau protein hyper-phosphorylation. Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both ...
Debra Toiber, Amit Berson, David Greenberg, Naomi Melamed-Book, Sophia Diamant, Hermona Soreq   +5 more
doaj   +1 more source

An In Silico Study Based on QSAR and Molecular Docking and Molecular Dynamics Simulation for the Discovery of Novel Potent Inhibitor against AChE

Pharmaceuticals
Acetylcholinesterase (AChE) is one of the main drug targets for treating Alzheimer’s disease. This current study relies on multiple molecular modeling approaches to develop new potent inhibitors of AChE.
Meriem Khedraoui, Oussama Abchir, H. Nour, I. Yamari, Abdelkbir Errougui, Abdelouahid Samadi, S. Chtita   +6 more
semanticscholar   +1 more source

Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives

Molecules, 2019
Alzheimer’s disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory.
U. Acar Çevik, B. Sağlık, Serkan Levent, Derya Osmaniye, Betül Kaya Çavuşoğlu, Yusuf Ozkay, Z. Kaplancıklı   +6 more
semanticscholar   +1 more source

NLC-Based Sunscreen Formulations with Optimized Proportion of Encapsulated and Free Filters Exhibit Enhanced UVA and UVB Photoprotection

Pharmaceutics
The topical use of sunscreens is recommended for avoiding the damaging effects of UV radiation. However, improvements are still needed in the existing products to enhance their photoprotection effectiveness and safety. This involves minimizing the use of
Margarete M. de Araújo, Andressa C. Schneid, Mariana S. Oliveira, Samuel V. Mussi, Miller N. de Freitas, Flávia C. Carvalho, Edson A. Bernes Junior, Renato Faro, Hatylas Azevedo   +8 more
doaj   +1 more source

Baicalein as a Potential Inhibitor against BACE1 and AChE: Mechanistic Comprehension through In Vitro and Computational Approaches

Nutrients, 2019
One of the major neurodegenerative features of Alzheimer’s disease (AD) is the presence of neurotoxic amyloid plaques composed of amyloid beta peptide (Aβ).
Jin Han, Yeongseon Ji, Kumju Youn, Gyutae Lim, Jinhyuk Lee, Dong Hyun Kim, Mira Jun   +6 more
semanticscholar   +1 more source

Acetylcholinesterase involvement in apoptosis

Frontiers in Molecular Neuroscience, 2012
To date, more than 40 different types of cells from primary cultures or cell lines have shown AChE expression during apoptosis and after the induction apoptosis by different stimuli. It has been well-established that increased AChE expression or activity
Xue-Jun eZhang, David S. eGreenberg
doaj   +1 more source

Altered levels of acetylcholinesterase in Alzheimer plasma. [PDF]

PLoS ONE, 2010
BACKGROUND: Many studies have been conducted in an extensive effort to identify alterations in blood cholinesterase levels as a consequence of disease, including the analysis of acetylcholinesterase (AChE) in plasma.
María-Salud García-Ayllón, Iolanda Riba-Llena, Carol Serra-Basante, Jordi Alom, Rathnam Boopathy, Javier Sáez-Valero   +5 more
doaj   +1 more source

Estimation of plasma and RBC acetylcholinesterase in children: An evaluation tool for Hirschsprung's disease?

Indian Journal of Pathology and Microbiology, 2021
Background: Increased acetylcholinesterase (AChE) activity on frozen sections of rectal mucosal biopsies accurately diagnoses Hirschsprung disease (HD). But the quest for a biomarker in blood as a screening test prompts one to look for AChE in blood and ...
Neha Kuvelkar, Serena DSouza, K Vidhyashree, Gowri Shankar, Maria Frances Bukel, Santosh Noronha, Usha Kini   +6 more
doaj   +1 more source

Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment of AD. Most of these compounds exhibited strong and clearly selective inhibition to eeAChE.
Jie Fu, Fengqi Bao, M. Gu, Jing Liu, Zhipeng Zhang, Jiaoli Ding, Sai-Sai Xie, Jinsong Ding   +7 more
semanticscholar   +1 more source

Tok&ache

Processando o Saber, 2021
O município de Peruíbe possui uma sazonalidade turística expressiva e uma forte dependência econômica dos setores comercial e de serviços, entretanto apresentam um suporte inadequado de propaganda e marketing quanto à ubiquidade, custos e responsividade.
Jonatas Cerqueira Dias, Jean Francisco Lessa, Michel Schaaf Lessa, Jeferson Cerqueira Dias   +3 more
doaj