Results 91 to 100 of about 7,605,068 (272)

Acid–base

, 2016
Stewart’s strong ion approach to acid–base disorders is increasingly popular, especially in critical care medicine. However, the Henderson–Hasselbalch-based bicarbonate-centered approach remains widely used.
Pieter Roel Tuinman, Gatz, Rainer, Rainer Gatz, van Bochove, Victor A., Victor A. van Bochove, Paul W. G. Elbers, Elbers, Paul W.G., Tuinman, Pieter Roel   +7 more
core   +1 more source

Acid-base disorders in critically ill neonates

, 2010
Objective: To study acid-base imbalance in common pediatric diseases (such as sepsis, bronchopneumonia, diarrhea, birth-asphyxia etc.) in neonates. Design and Setting: An observational study was conducted in an emergency room of a tertiary teaching care ...
Vaswani, N. D., Shanker, V., Gathwala, G., Lekhwani, S.   +3 more
core   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Delayed Awakening from Anesthesia Following Electrolyte and Acid-Base Disorders, Two Cases [PDF]

Patient Safety and Quality Improvement Journal, 2014
Introduction: Delayed awakening from anesthesia remains one of the biggest challenges that involve anesthesiologists. Most commonly, delayed awakening is due to drugs effects persistence.
Razavi M, Bameshki AR, Taghavi Gilani M
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

pH sensors and ion Transporters: Potential therapeutic targets for acid-base disorders. [PDF]

Int J Pharma Res Rev, 2016
Regulation of pH is critical for physiological processes. Maintenance of acid-base homeostasis is tightly regulated by the renal and respiratory systems. However, fluctuations in extracellular pH are also sensed by other organ systems.
Atkinson KF, Nauli SM.
europepmc   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Acid-Base Solutions

, 2016
Ensino Médio::QuímicaConhecimentos sobre ácidos, bases, pH e equilíbrio químicoA simulação permite explorar propriedades como pH, condutividade elétrica de soluções de ácidos e bases fortes e fracas, além de verificar as concentrações de equilíbrio das ...
Loeblein, Patricia, Perkins, Kathy, Malley, Chris, Parson, Robert, Lancaster, Kelly   +4 more
core   +1 more source

Spurious Electrolyte and Acid-Base Disorders in the Patient With Cancer: A Review. [PDF]

Am J Kidney Dis, 2023
Chowdhury R, Turcotte AE, Rondon-Berrios H, Workeneh BT.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source