Results 121 to 130 of about 431,167 (287)

Revisiting Stewart's Approach toward Assessment of Unidentified or Complex Acid-Base Disorders. [PDF]

Indian J Crit Care Med, 2022
Gopaldas JA.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Metabolic alkalosis is related to delayed response to treatment of hypokalemia in non-surgical critically ill patients

Journal of Community Hospital Internal Medicine Perspectives, 2019
Background: Potassium (K+) homeostasis is closely related to acid – base disorders. The aim of this study is to analyze the possible causes of hypokalemia non-surgical critically ill patients including acid – base disorders and its relationship with ...
Felipe Cañas, Eduardo Orrego-González, Daniel Eduardo-Celin, Jorge Martínez B., Liliana Mesa Ramírez   +4 more
doaj   +1 more source

Acid base disorders in patients with COVID-19. [PDF]

Int Urol Nephrol, 2022
Alfano G, Fontana F, Mori G, Giaroni F, Ferrari A, Giovanella S, Ligabue G, Ascione E, Cazzato S, Ballestri M, Di Gaetano M, Meschiari M, Menozzi M, Milic J, Andrea B, Franceschini E, Cuomo G, Magistroni R, Mussini C, Cappelli G, Guaraldi G, Modena Covid-19 Working Group (MoCo19).   +21 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome. [PDF]

J Clin Med, 2022
Chiumello D, Pozzi T, Fratti I, Modafferi L, Montante M, Papa GFS, Coppola S.   +6 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

ABG Assistant-Towards an Understanding of Complex Acid-Base Disorders. [PDF]

J Clin Med, 2021
Gutowski Ł, Gutowska K, Brożek A, Nowicki M, Formanowicz D.   +4 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review. [PDF]

Antibiotics (Basel), 2021
Scoglio M, Bronz G, Rinoldi PO, Faré PB, Betti C, Bianchetti MG, Simonetti GD, Gennaro V, Renzi S, Lava SAG, Milani GP.   +10 more
europepmc   +1 more source