Results 81 to 90 of about 1,959,957 (289)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A Multi-Institution Mixed Methods Analysis of a Novel Acid-Base Mnemonic Algorithm

Multimodal Technologies and Interaction
Acid-base analysis is a high-load diagnostic skill that many medical students struggle to master when taught using traditional text-based flowcharts. This multi-institution mixed-methods study evaluated a novel visual mnemonic algorithm that integrated ...
Camille Massaad, Harrison Howe, Meize Guo, Tyler Bland   +3 more
doaj   +1 more source

Iodine and pregnancy – a UK cross-sectional survey of dietary intake, knowledge and awareness [PDF]

, 2015
Iodine is a key component of the thyroid hormones, which are critical for healthy growth, development and metabolism. The UK population is now classified as mildly iodine-insufficient.
Bouga, M., Christopher, C.O., Combet, E., Lean, M.E.J., Pan, B.   +4 more
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Teaching acid-base theories in the era of disinformation: A systematic review with proposals for content integration

Eclética Química
This paper is rooted in the premise that addressing scientific disinformation and misinformation about acid-base theories requires a multidisciplinary approach, approximating acid-base knowledge with content typically not addressed in chemistry classes ...
Erasmo Moises dos Santos Silva, Agnaldo Arroio   +1 more
doaj   +1 more source

Chronic Kidney Disease in Cats and the Risk of Total Hypercalcemia [PDF]

, 2017
BACKGROUND: Chronic kidney disease (CKD) is a common comorbidity in cats with hypercalcemia, but whether CKD is a risk factor for hypercalcemia is unclear.
Abdi, Andress, Barber, Barber, Barber, Berend, Berry, Bertazzolo, Bienzle, Blaine, Block, Burnell, Bushinsky, Chakrabarti, Cole, Costanzo, DiBartola, Elliott, Elliott, Eren, Finch, Flanders, Fogh-Andersen, Gal, Gauci, Geddes, Geddes, He, Jackson, Kelly, Kogika, Kovesdy, Kurz, Lemann, Levi, Levi, Lulich, Malatesha, Marino, Marone, McLeland, Meghji, Meuten, Midkiff, Must, Payne, Peacock, Picolos, Pieper, Piraino, Polzin, Rafferty, Savary, Schenck, Schenck, Schenck, Schenck, Schenck, Schenck, Schenck, Shanahan, Shipov, Sutton, Tentori, Williams, Yamada, Yang   +66 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Facing acid–base disorders in the third millennium – the Stewart approach revisited

International Journal of Nephrology and Renovascular Disease, 2014
R Kishen,1,2 Patrick M Honoré,3 R Jacobs,3 O Joannes-Boyau,4 E De Waele,3 J De Regt,3 V Van Gorp,3 W Boer,5 HD Spapen3 1Intensive Care Unit, Salford Royal Hospitals NHS Trust, Salford, Manchester, UK (formerly); 2Translational Medicine and ...
Kishen R, Honoré PM, Jacobs R, Joannes-Boyau O, De Waele E, De Regt J, Van Gorp V, Boer W, Spapen HD   +8 more
doaj  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source