Results 71 to 80 of about 1,392,835 (305)

A Novel Single Nucleotide Polymorphism in Exon 4 of Insulin-Like Growth Factor-1 Associated with Production Traits in Bali Cattle [PDF]

, 2012
Insulin-like growth factor-1 (IGF-1) is one of the gene candidates that can be used in selection strategy by using DNA markers (marker assisted selection).
Arman, C. (C), Gurnadi, E. (E), Maskur, M. (Maskur), Muladno, M. (Muladno), Sumantri, C. (C)   +4 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Critical Response Training for Surgical Interns

MedEdPORTAL, 2010
Introduction In order to provide safe, timely, and effective care for our patients, it is imperative that surgical interns are prepared to recognize and manage acute postoperative complications, particularly those emergencies which are life-threatening ...
Mara Antonoff, Jeffrey Chipman, Connie Schmitz, Jonathan DCunha   +3 more
doaj   +1 more source

Observations of heterogeneous reactions between Asian pollution and mineral dust over the Eastern North Pacific during INTEX-B [PDF]

, 2009
In-situ airborne measurements of trace gases, aerosol size distributions, chemistry and optical properties were conducted over Mexico and the Eastern North Pacific during MILAGRO and INTEX-B.
Anderson, B. E., Clarke, A. D., Cohen, R. C., Crounse, J. D., DeCarlo, P. F., Dibb, J., Dunlea, E. J., Flocke, F., Howell, S. G., Huey, L G., Jimenez, J. L., Kapustin, V., Kim, S., McNaughton, C. S., Perring, A., Scheuer, E., Shinozuka, Y., Weinheimer, A. J., Wennberg, P. O., Winstead, E., Wooldridge, P.   +20 more
core   +3 more sources

Integrating functional diversity, food web processes, and biogeochemical carbon fluxes into a conceptual approach for modeling the upper ocean in a high-CO2 world [PDF]

, 2005
Marine food webs influence climate by channeling carbon below the permanent pycnocline, where it can be sequestered. Because most of the organic matter exported from the euphotic zone is remineralized within the "upper ocean" (i.e., the water column ...
Legendre, Louis, Rivkin, Richard B.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties [PDF]

, 2019
Purified phlorotannin extracts from four brown seaweeds (Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira usneoides (Linnaeus) M.
Andrade, Paula, Ferreres, Federico, Gil-Izquierdo, Angel, Lopes, Graciliana, Mouga, Teresa, Sousa, Carla, Valentão, Patrícia   +6 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Combined ACEI and ARB therapy and ICU mortality in critically ill COVID-19 patients: a retrospective cohort study

Frontiers in Pharmacology
IntroductionThe clinical safety and potential benefits of renin–angiotensin–aldosterone system (RAAS) inhibitors in COVID-19 remain debated, particularly in critically ill populations.
Ivanny Marchant, Ivanny Marchant, Gloria Balcazar, Gloria Balcazar, Valentina Pozo, Valentina Pozo, Pablo Olivero, Pablo Olivero, Belén Rodríguez, Belén Rodríguez, Romina Castillo, Romina Castillo, Hilda Espinoza, Hilda Espinoza   +13 more
doaj   +1 more source

Effects of low seawater pH on the marine polychaete Platynereis dumerilii [PDF]

, 2015
An important priority for any organism is to maintain internal cellular homeostasis including acidbase balance. Yet, the molecular level impacts of changing environmental conditions, such as low pH, remain uncharacterised.
Arendt, Detlev, Chapman, Emma C., Hardege, Joerg D., Hardege, Jörg D., Larsson, Tomas A., Rotchell, Jeanette M., Simakov, Oleg, Waege, Janine, Wäge, Janine   +8 more
core   +1 more source